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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	4292-10-8
Chemical Name	2-[3-(Dodecanoylamino)prop-1-yl(dimethyl)aminio]acetate
Substance ID	24A6140
Classification year (FY)	FY2012
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Classification not possible	- -	-	-	Due to no description of a flash point, it was judged as "Classification not possible."
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	The substance is an organic substance containing oxygen which is chemically bonded only to carbon. Therefore, it was judged as "Not applicable."
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	No data available. Besides, for alkylamidopropyl betaine of C8-C18 (30-35.5% aqueous solutions), there is a report on an LD50 value of > 5,000 mg/kg (active substance: > 1,500 mg/kg) for rats, and the acute toxicity value of this substance was estimated to be in the same range (SIAP (2006)).
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available. Besides, for alkylamidopropyl betaine of C8-C18 (30-35.5% aqueous solutions), there is a report on an LD50 value of > 2,000 mg/kg (active substance: > 600 mg/kg) for rats, and the acute toxicity value of this substance was estimated to be in the same range (SIAP (2006)).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	No data available. Besides, alkylamidopropyl betaine of C8-C18 (30% aqueous solution) was very slightly irritating in a test in which it was applied to rabbits (OECD TG 404), and the skin-irritating potential of this substance was estimated to be similar (SIAP (2006)).
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available. Besides, it is reported that in a test in which alkylamidopropyl betaine of C8-C18 (30% aqueous solution) was applied to rabbits, cornea and iris damage occurred and was still present in some animals at the end of a 21-day observation period, and the eye-irritating potential of this substance was estimated to be similar (SIAP (2006)).
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.
4	Skin sensitization	Classification not possible	- -	-	-	No data available.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	No data available.
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available. Besides, in a developmental toxicity test on alkylamidopropyl betaine of C8-C18 (28.9% aqueous solution) (OECD TG 414), dose-related maternal toxicity (reduced body weights, stomach ulcers) occurred, embryotoxicity such as increased numbers of resorptions and a decreased number of viable fetuses was observed only in the high dose group, and similar results were estimated for this substance (SIAP (2006)).
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	No data available.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	No data available. Besides, in a test by 28-day or 90-day repeated oral administration of alkylamidopropyl betaine of C8-C18 (30% aqueous solution) (75, 150, and 300 mg/kg bw/day) (OECD TG 407 and 408), the only treatment-related effects were lesions in the stomach, probably due to irritation, and similar effects were estimated for this substance (SIAP (2006)).
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Classification not possible	- -	-	-	No data available.
11	Hazardous to the aquatic environment (Long-term)	Classification not possible	- -	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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