GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 6165-51-1
Chemical Name 1,4-Dimethyl-2-(1-phenylethyl)benzene
Substance ID 24A6148
Classification year (FY) FY2012
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Not classified
-
-
- - From a flash point of 425 deg C [open-cup (COC)] (SIDS (2012)) of > 93 deg C, it is estimated that it does not flash off at 93 deg C or below in the prescribed closed-cup method.
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Classification not possible
-
-
- - No data available.
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Organic compounds containing no oxygen, fluorine or chlorine.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure.
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- - An LD50 value was estimated to be >= 2,000 mg/kg because 1/5 males and 2/5 females died after the administration of 2,000 mg/kg in a single administration toxicity test with rats (OECD TG 401, GLP) (JECDB (2001)). Therefore, it was classified as "Not classified" in the Classification JIS (corresponding to Category 5 in UN GHS classification).
1 Acute toxicity (Dermal) Classification not possible
-
-
- - No data available.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - No data available.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - No data available.
2 Skin corrosion/irritation Classification not possible
-
-
- - No data available.
3 Serious eye damage/eye irritation Classification not possible
-
-
- - No data available.
4 Respiratory sensitization Classification not possible
-
-
- - No data available.
4 Skin sensitization Classification not possible
-
-
- - No data available.
5 Germ cell mutagenicity Classification not possible
-
-
- - The classification is not possible due to no in vivo test data. Besides, as for in vitro tests, it is reported that it was negative in both an Ames test and a chromosomal aberration test with CHL/IU cells (JECDB (Access on Dec. 2012)).
6 Carcinogenicity Classification not possible
-
-
- - No data available.
7 Reproductive toxicity Classification not possible
-
-
- - In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test by oral administration to rats (OECD TG 422, GLP, doses: 0, 12.5, 50, 200 mg/kg/day), in parent animals, reduced weight gain or a trend toward reduced weight gain was observed in males in the 200 mg/kg group during the latter part of administration period and in females during gestation and nursing period. On the other hand, as for reproductive function, no treatment effects were found in estrous cycle, the number of corpus luteum, the number of implantation sites, copulation index, fertility index, and duration of mating. And on examination on parturition and lactation, no effects of the test substance were seen in gestation length, gestation index, the number of newborns, live birth index, the number of live newborns, stillborn index, sex ratio, body weights of offspring on lactation days 0 and 4, and viability index on day 4, and examination on neonatal surface revealed no anomalies (JECDB (2001)). From the above results, no treatment-related adverse effects were shown on sexual function/fertility, but as for the development of offspring, there were no data on the examination of fetuses at the end of gestation. Because data are insufficient on effects on the development of offspring, it was classified as "Classification not possible."
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - In a single administration toxicity test with rats (OECD TG 401, GLP), one male and two females died in the 2,000 mg/kg group, and on observation of general status, no abnormalities were seen on the day of the administration, but one day after the administration, bradypnea and lateral position were observed in one female in the 2,000 mg/kg group, and soiled perianal region and hypoactivity were found in males and females in the 2,000 mg/kg group. On pathological examination, no macroscopic abnormalities were seen in the organs in the surviving animals, one dead male in the 2,000 mg/kg group showed macroscopic and histological anomalies in the kidney and thymus, and one dead female in the 2,000 mg/kg group showed macroscopic and histologic changes in the lung (JECDB (2001)). From the above report, deaths of some animals were observed at 2,000 mg/kg, but the surviving animals did not have abnormalities, and it was hard to specify the target organ. Therefore, it was classified as "Classification not possible."
9 Specific target organ toxicity - Repeated exposure Category 2 (adrenal gland)


Warning
H373 P260
P314
P501
In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test by oral administration to rats (OECD TG 422, GLP, doses: 0, 12.5, 50, 200 mg/kg/day), the incidence of hypertrophy of zona glomerulosa cells in the adrenal gland increased in males in the 200 mg/kg group (converted guidance value: 77.8 mg/kg/day) corresponding to the guidance value range for Category 2. From the description that hypertrophy of zona glomerulosa cells was considered to be caused by electrolyte imbalance, and an increase in urine volume also observed in males in the group was suspected to be related to the change (JECDB (2001)), it was classified in Category 2 (adrenal gland). Besides, there were increased liver weights in males at or above 50 mg/kg and females at 200 mg/kg, and centrilobular hypertrophy of hepatocytes was found histologically, but it was not adopted for classification because it is described that such centrilobular hypertrophy of hepatocytes is known to occur related to the induction of drug-metabolizing enzymes, and it was estimated to occur through a similar mechanism in this test (JECDB (2001)).
10 Aspiration hazard Classification not possible
-
-
- - No data available.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1


Warning
H400 P273
P391
P501
It was classified in Category 1 from 48-hour EC50 = 0.25 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999); SIDS, 2004).
11 Hazardous to the aquatic environment (Long-term) Category 1


Warning
H410 P273
P391
P501
It was classified in Category 1 due to being not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2003)), and 21-day NOEC = 0.009 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999); SIDS, 2004).
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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