Item | Information |
---|---|
CAS RN | 628-96-6 |
Chemical Name | Nitroglycol |
Substance ID | 24B6511 |
Classification year (FY) | FY2012 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | Physical Hazards and Health Hazards: GHS Classification Guidance by the Japanese Government (July, 2010) Environmental Hazards: UN GHS Document (4th revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Unstable Explosive |
Danger |
H200 |
P201
P202 P280 P372 P373 P380 P401 P501 |
Transportation of the pure substance is prohibited in UNRTDG, and the diluted product is classified in Division 1.1D. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Not classified |
- |
- | - |
A flash point of 114 deg C (IUCLID (2000)) is above 93 deg C. |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | It was classified in explosives. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 217 deg C (GESTIS (Access on Mar. 2012)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Classification not possible |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to nitrogen. However, the classification is not possible due to no data. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
It was classified in Category 4 based on LD50 values for rats of 460 mg/kg (Environmental Risk Assessment for Chemical Substances vol. 7 (Ministry of the Environment, 2009)) and 616 mg/kg (PATTY (5th, 2001)). |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | It was classified as "Not classified" based on an LD50 value of 16,000 mg/kg for rats (Japanese Journal of Industrial Health Vol. 28 No. 3 (1986)). |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Data are lacking. Besides, it is described that no animal tests for skin effects have been reported, however, extensive human experiences indicate that this substance is not likely to give rise to skin irritation (PATTY (5th, 2001)). It is reported that a test conducted on 20 persons indicated 0.1% to 0.5% of this substance did not cause skin irritation for any of the test subjects (NIOSH Publications (2011)), but it could not be the basis for "Not classified" because the test substance was very diluted. |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | No data available. Besides, it is described that there are no reports of eye tests, however, extensive human experiences indicate that eye contact is not likely to cause significant irritation (PATTY (5th, 2001)). |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | No data available. |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data available. |
8 | Specific target organ toxicity - Single exposure | Category 1 (cardiovascular system) |
Danger |
H370 |
P308+P311
P260 P264 P270 P321 P405 P501 |
It is reported that inhalation exposure of humans to this substance caused severe cranioencephalic dilatation, as shown by an increase in systolic blood pressure, an increase in cerebral flow, and an increase in vasoelasticity with a reduction in local capillary resistance (PATTY (5th, 2001)), and the main poisoning symptoms of this substance include headache due to vasodilatation, a decrease in blood pressure, and paresthesia of the distal ends of limbs (Japanese Journal of Industrial Health Vol. 28 No. 3 (1986)), and the toxic dose of this substance can be readily absorbed through the skin and may affect the cardiovascular system, lowering blood pressure (Environmental Risk Assessment for Chemical Substances vol. 7 (Ministry of the Environment, 2009)). And it is described that the target organ of this substance is the cardiovascular system (Netherlands assessment document (2005)). From the above, it was classified in Category 1 (cardiovascular system). Besides, also in experimental animals, it is described that the chief effect is blood vessel dilation after oral administration to rats (PATTY (5th, 2001)). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (cardiovascular system, nervous system, blood) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
In a survey of workers in an explosives plant, headache, an increase in pulse rate, and a decrease in (systolic) blood pressure were observed, depending on the exposure amount (Environmental Risk Assessment for Chemical Substances vol. 7 (Ministry of the Environment, 2009)), and abnormal pulse waves were found in 143 out of 1271 workers (none in 175 controls) in another explosives plant (ACGIH (7th, 2001)). The main poisoning symptoms of this substance include headache due to vasodilatation, a decrease in blood pressure, and paresthesia of the distal ends of limbs (Japanese Journal of Industrial Health Vol. 28 No. 3 (1986)), and this substance can be readily absorbed through the skin and may affect the cardiovascular system, lowering blood pressure (Environmental Risk Assessment for Chemical Substances vol. 7 (Ministry of the Environment, 2009)). It was classified in Category 1 (cardiovascular system) based on epidemiological findings that showed cardiovascular effects, as shown in the above. And as standards for certifying nitroglycol poisoning in the workplace, having following symptoms is described: syncope, weakness or cold feeling of limbs, and numbness of the distal ends of limbs (especially fingers) other than heart symptoms (Notification No. 489, Ministry of Health, Labour and Welfare). Therefore, it was classified in Category 1 (nervous system). On the other hand, Heinz body formation in the erythrocytes and pathological changes in the liver and spleen similar to those seen in anemia were observed after 6-month inhalation administration of rats or guinea pigs to 80 ppm (0.496 mg/L) (PATTY (5th, 2001)), and after 1000-day inhalation exposure of cats to 0.155-0.196 mg/L (vapour: 6-hour converted value), in addition to decreased erythrocyte counts, decreased hemoglobin level, and increased reticulocyte counts, methemoglobin was detected in all animals (Environmental Risk Assessment for Chemical Substances vol. 7 (Ministry of the Environment, 2009)). Because the exposure concentrations for cats correspond to the guidance values for Category 1, it was classified in Category 1 (blood). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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