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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	29911-28-2
Chemical Name	Dipropylene glycol butyl ether
Substance ID	25A0006
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Not classified	- -	-	-	Based on a flash point of 111 deg C (closed cup) (ICSC (2006)), it was classified as "Not classified" due to being above 93 deg C.
7	Flammable solid	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 194 deg C (ICSC (2006)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	From an oral LD50 value for rats of 4,000 mg/kg (males, females) [OECD TG 401, GLP-compliant] (SIDS (2005)), it was classified as "Not classified" in the Classification JIS (Category 5 in UN GHS classification). Besides, there are other data: LD50 = about 1,850 mg/kg (SIDS (2005)), 1,500 mg/kg (females), and 2,032 mg/kg (males) (above, PATTY (6th, 2012)), but GLP-compliant data were adopted.
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" based on reports that a dermal LD50 value was > 2,000 mg/kg for rats, and there were no deaths or signs of toxicity at 2,000 mg/kg [OECD TG 402] (SIDS (2005)), and that a dermal LD50 value was > 2,000 mg/kg for rabbits (PATTY (6th, 2012)).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, it is reported that in a test with rats (males, females) exposed to the vapour of this substance for 4 hours, there were no death cases at > 42.1 ppm (SIDS (2005)). Because the test concentration is lower than the saturated vapour pressure concentration of 89.832 ppm, a reference value in the unit of ppm was applied as a vapour with little mist.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, it is reported that in a test with rats (males, females) exposed to the aerosol of this substance for 4 hours, there were no death cases at > 2.04 mg/L (SIDS (2005)). Because the test concentration is higher than the saturated vapour pressure concentration of 0.6991 mg/L, a reference value in the unit of mg/L was applied as a mist.
2	Skin corrosion/irritation	Not classified	- -	-	-	It was classified as "Not classified" because there was no irritation in a skin irritation test with rabbits (SIDS (2005)).
3	Serious eye damage/eye irritation	Not classified	- -	-	-	It was classified as "Not classified" because there was no irritation in an eye irritation test with rabbits (SIDS (2005)).
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Not classified	- -	-	-	It is reported in SIDS (2005) that it was negative in a Buehler test with guinea pigs (according to OECD TG 406). Because the test complies with the OECD test guideline as to the number of animals in a test group (20), a method of applying test substance, etc., it was classified as "Not classified."
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a micronucleus test with mouse bone marrow cells (IUCLID (2000)). As for in vitro, it was negative in a bacterial reverse mutation test and a gene mutation test with cultured mammalian cells (IUCLID (2000)), and there were negative and positive results in chromosomal aberration tests with cultured mammalian cells (IUCLID (2000)). However, it is described in SIDS (2005) that there is no evidence that a series of polyethyleneglycols including this substance poses in vivo genotoxicity.
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" due to no carcinogenicity test data on this substance. Besides, as a related substance, there are data from a chronic toxicity/carcinogenicity test on propylene glycol methyl ether, in which carcinogenicity was not observed (SIDS (2005)).
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. In a developmental toxicity test with rats by dermal exposure, developmental toxicity was not found (SIDS (2005), PATTY (6th, 2012)). However, because no other information was obtained, it was classified as "Classification not possible" due to lack of data.
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, on the dermal route, because in dermal administration to rats (OECD TG 402), no toxicity was observed at the dose (2,000 mg/kg) within the guidance value range (SIDS (2005)), it corresponds to "Not classified." There is no information on the other routes.
9	Specific target organ toxicity - Repeated exposure	Category 2 (respiratory organs, liver)	Warning	H373	P260 P314 P501	In oral administration to rats, no toxicity findings were observed within guidance value ranges for Category 1-2 (SIDS (2005)). However, in a test in which rats were given 2-week inhalation exposure to the aerosol of this substance, enlargement of hepatocytes was observed in addition to changes in the nasal epithelium (hyperplasia, squamous metaplasia, etc.) at the concentration (converted guidance value: 0.09 mg/L) within the guidance value range for Category 2 (SIDS (2005)), therefore, target organs are thought to be the respiratory organs and liver. From the above, it was classified in Category 2 (respiratory organs, liver).
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Not classified	- -	-	-	From 72-hour ErC50 = 556.4 mg/L for algae (Green Alga) (SIDS, 2005), 48-hour LC50 > 1000 mg/L for crustacea (Daphnia magna) (SIDS, 2005), and 96-hour LC50 = 841 mg/L (SIDS, 2005) for fish (Danio rerio), it was classified as "Not classified."
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. It was classified as "Not classified" because it is not water-insoluble (water solubility = 5 g/100 mL, (ICSC, 2006)), and it was classified as "Not classified" in acute toxicity.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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