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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	34090-76-1
Chemical Name	Tetrahydro-4-methylphthalic anhydride
Substance ID	25A0008
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Classification not possible	- -	-	-	No data available. Besides, a flash point of tetrahydromethylphthalic anhydride (CAS RN 11070-44-3), an isomer mixture of this substance is 157 deg C (open cup) (SIDS (2005)), corresponding to "Not classified."
7	Flammable solid	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Classification not possible	- -	-	-	No data available.
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, for the mixture of isomers of this substance, tetrahydromethylphthalic anhydride (CAS RN 11070-44-3), LD50 values of 1,900 mg/kg, 2,102 mg/kg, and 2,140 mg/kg for rats are reported (SIDS (2005)) and correspond to "Not classified" in the Classification JIS (Category 5 in UN GHS classification).
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, it is described in SIDS (2005) that for the mixture of isomers of this substance, tetrahydromethylphthalic anhydride (CAS RN 11070-44-3), moderate irritation was observed in a skin irritation test with rabbits, not a 4-hour application test, corresponding to Category 2.
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, it is described in SIDS (2005) that for the mixture of isomers of this substance, tetrahydromethylphthalic anhydride (CAS RN 11070-44-3), in an eye irritation test, irritation to the eye was observed, and it was not fully reversible at the observation 10 days after application, and it corresponds to Category 2A. Besides, it is classified in "Xi; R41" in EU DSD classification and "Eye Dam. 1 H318" in EU CLP classification.
4	Respiratory sensitization	Classification not possible	- -	-	-	Respiratory sensitization: classification not possible due to lack of data. Besides, for the mixture of isomers of this substance, tetrahydromethylphthalic anhydride (CAS RN 11070-44-3), respiratory sensitization was observed in multiple epidemiological cases in humans in the Environmental Risk Assessment for Chemical Substances vol. 4 (Ministry of the Environment, 2005). Besides, it is classified in "R42/43" in EU DSD classification and "Resp. Sens. 1 H334" in EU CLP classification, corresponding to Category 1.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, for the mixture of isomers of this substance, tetrahydromethylphthalic anhydride (CAS RN 11070-44-3), skin sensitization was observed in multiple epidemiological cases in humans in the Environmental Risk Assessment for Chemical Substances vol. 4 (Ministry of the Environment, 2005). Besides, it is classified in "Xi; R42/43" in EU DSD classification and "Skin Sens. 1 H317" in EU CLP classification, corresponding to Category 1.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There are no in vivo or in vitro data. Besides, for the mixture of isomers of this substance, tetrahydromethylphthalic anhydride (CAS RN 11070-44-3), it is reported in Chemical Substance Hazard Data 2001-62 (CERI, 2002), JECDB (Access on September 2013), SIDS (2005) that there is no heritable mutagenicity test, in vivo germ cell/somatic cell mutagenicity test, or in vivo germ cell/somatic cell genotoxicity test and that in an in vitro mutagenicity test, there was no (strong) positive result in multiple parameters.
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, for the mixture of isomers of this substance, tetrahydromethylphthalic anhydride (CAS RN 11070-44-3), in humans, it is described that the substance is known to cause strong irritation, and there are many reports on symptoms in the eye and respiratory tract (Chemical Substance Hazard Data 2001-62 (CERI, 2002)), and in experimental animals, there are descriptions of hypoactivity, bradypnea, prone position, recoveries within three days after administration, etc. (JECDB (Access on September 2013)), corresponding to Category 3 (respiratory tract irritation, narcotic effects).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data.
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Classification not possible	- -	-	-	No data available.
11	Hazardous to the aquatic environment (Long-term)	Classification not possible	- -	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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