Item | Information |
---|---|
CAS RN | 25584-83-2 |
Chemical Name | Monoester of acrylic acid and propan-1,2-diol |
Substance ID | 25A0018 |
Classification year (FY) | FY2013 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance by the Japanese Government (July, 2013) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Not classified |
- |
- | - | From data: a flash point of 97 deg C (closed cup) (HSDB (Access on September 2013)) above 93 deg C, it was classified as "Not classified." |
7 | Flammable solid | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | There is an acrylic group that is an unsaturated bond in the molecule, but the classification is not possible due to no data. Besides, there is information that above 97 deg C, explosive vapour/air mixtures may be formed (ICSC (J) (2009)). |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
Among LD50 values for rats, 250-500 mg/kg (ACGIH (7th, 2001), SIDS (2006)) corresponds to Category 3 or Category 4, and 590-1,300 mg/kg (ACGIH (7th, 2001)), 820 mg/kg (SIDS (2006)), 950-1,130 mg/kg (DFGOT vol. 16 (2001)), 1,180 mg/kg (SIDS (2006), DFGOT vol. 16 (2001)), and 1,290 mg/kg (SIDS (2006)) correspond to Category 4. It was classified in Category 4 to which most data correspond. |
1 | Acute toxicity (Dermal) | Category 2 |
Danger |
H310 |
P302+P352
P361+P364 P262 P264 P270 P280 P310 P321 P405 P501 |
There are four reports on LD50 values for rabbits. Among these, 117 mg/kg (SIDS (2006), DFGOT vol. 16 (2001)) and 168 mg/kg (SIDS (2006)) correspond to Category 2, and 214 mg/kg (SIDS (2006)) and 306 mg/kg (SIDS (2006)) correspond to Category 3. Because there is the same number of reports for both categories, by adopting the category for the minimum LD50 value, it was classified in Category 2. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 |
P301+P330+P331
P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
In SIDS (2006), there are seven reports on skin irritation tests with rabbits, and in each test, it was assessed to be not corrosive but highly irritating (SIDS (2006)). Besides, this substance is classified in "C; R34" in EU DSD classification and "Skin Corr. 1B H314" in EU CLP classification. Based on the above information, it was classified in Category 1. |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
It is described in SIDS (2006) that it was assessed to be moderately to severely irritating in four eye irritation tests with rabbits, and corneal injury may result in permanent impairment of vision, even blindness. Therefore, it was classified in Category 1. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. |
4 | Skin sensitization | Category 1 |
Warning |
H317 |
P302+P352
P333+P313 P362+P364 P261 P272 P280 P321 P501 |
Results of multiple tests with animals were described in SIDS (2006), and all of them gave a positive result that there was sensitization. Multiple positive results are also described in an epidemiological survey in humans or case reports. Moreover, this substance is classified in "R43" in EU DSD classification and "Skin Sens. 1 H317" in EU CLP classification. Based on the above information, it was classified in Category 1. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. As for in vivo, it was negative in a micronucleus test with mouse bone marrow cells (SIDS (2006)). As for in vitro, there are both negative and positive results in bacterial reverse mutation tests, and it was negative in a gene mutation test with cultured mammalian cells and positive in a chromosomal aberration test (SIDS (2006)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, in a developmental toxicity test with rats in the inhalation route, no developmental toxicity was observed even at the doses where maternal toxicity was found (SIDS (2006)). No report on fertility was obtained. |
8 | Specific target organ toxicity - Single exposure | Category 3 (respiratory tract irritation, narcotic effects) |
Warning |
H335
H336 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
Because nasal and respiratory tract irritation was observed at the concentration (3.43 mg/L) within the guidance value range in rats in the inhalation route (ACGIH (7th, 2001)), it was classified in Category 3 (respiratory tract irritation). Because in an oral administration test with rats, passiveness, ataxia, and salivation were found at the concentrations (710-2,000 mg/kg) within the guidance value range (SIDS (2006)), it was classified in Category 3 (narcotic effects). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
It is described that after 4-week inhalation exposure to the vapour of this substance in experimental animals (rats, mice, rabbits, dogs), irritation changes in the nasal mucosa and respiratory organs were observed at the concentrations (converted guidance value: 0.006 mg/L/6 hours or less) (SIDS (2006), ACGIH (7th, 2001), DFGOT vol.16 (2001)). Therefore, it was classified in Category 1 (respiratory organs). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 |
- |
H401 |
P273
P501 |
From 96-hour LC50 = 3.1 mg/L for fish (Pimephales promelas) (SIDS, 2006), it was classified in Category 2. |
11 | Hazardous to the aquatic environment (Long-term) | Not classified |
- |
- | - |
If chronic toxicity data are used, then it is classified as "Not classified" due to rapid degradability (a degradation rate by BOD: 83% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2001)), and 72-hour NOEC (r) = 5 mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 2006). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to rapid degradability (a degradation rate by BOD: 83% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2001)), and a low bioaccumulation estimate (log Kow = 0.35 (SIDS, 2006)) despite 96-hour LC50 = 3.1 mg/L for fish (Pimephales promelas) (SIDS, 2006). From the above results, it was classified as "Not classified." |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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