GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 25584-83-2
Chemical Name Monoester of acrylic acid and propan-1,2-diol
Substance ID 25A0018
Classification year (FY) FY2013
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Not classified
-
-
- - From data: a flash point of 97 deg C (closed cup) (HSDB (Access on September 2013)) above 93 deg C, it was classified as "Not classified."
7 Flammable solid Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible
-
-
- - There is an acrylic group that is an unsaturated bond in the molecule, but the classification is not possible due to no data. Besides, there is information that above 97 deg C, explosive vapour/air mixtures may be formed (ICSC (J) (2009)).
9 Pyrophoric liquids Classification not possible
-
-
- - No data available.
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule.
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P264
P270
P330
P501
Among LD50 values for rats, 250-500 mg/kg (ACGIH (7th, 2001), SIDS (2006)) corresponds to Category 3 or Category 4, and 590-1,300 mg/kg (ACGIH (7th, 2001)), 820 mg/kg (SIDS (2006)), 950-1,130 mg/kg (DFGOT vol. 16 (2001)), 1,180 mg/kg (SIDS (2006), DFGOT vol. 16 (2001)), and 1,290 mg/kg (SIDS (2006)) correspond to Category 4. It was classified in Category 4 to which most data correspond.
1 Acute toxicity (Dermal) Category 2


Danger
H310 P302+P352
P361+P364
P262
P264
P270
P280
P310
P321
P405
P501
There are four reports on LD50 values for rabbits. Among these, 117 mg/kg (SIDS (2006), DFGOT vol. 16 (2001)) and 168 mg/kg (SIDS (2006)) correspond to Category 2, and 214 mg/kg (SIDS (2006)) and 306 mg/kg (SIDS (2006)) correspond to Category 3. Because there is the same number of reports for both categories, by adopting the category for the minimum LD50 value, it was classified in Category 2.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
In SIDS (2006), there are seven reports on skin irritation tests with rabbits, and in each test, it was assessed to be not corrosive but highly irritating (SIDS (2006)). Besides, this substance is classified in "C; R34" in EU DSD classification and "Skin Corr. 1B H314" in EU CLP classification. Based on the above information, it was classified in Category 1.
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
It is described in SIDS (2006) that it was assessed to be moderately to severely irritating in four eye irritation tests with rabbits, and corneal injury may result in permanent impairment of vision, even blindness. Therefore, it was classified in Category 1.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Category 1


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501
Results of multiple tests with animals were described in SIDS (2006), and all of them gave a positive result that there was sensitization. Multiple positive results are also described in an epidemiological survey in humans or case reports. Moreover, this substance is classified in "R43" in EU DSD classification and "Skin Sens. 1 H317" in EU CLP classification. Based on the above information, it was classified in Category 1.
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data. As for in vivo, it was negative in a micronucleus test with mouse bone marrow cells (SIDS (2006)). As for in vitro, there are both negative and positive results in bacterial reverse mutation tests, and it was negative in a gene mutation test with cultured mammalian cells and positive in a chromosomal aberration test (SIDS (2006)).
6 Carcinogenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, in a developmental toxicity test with rats in the inhalation route, no developmental toxicity was observed even at the doses where maternal toxicity was found (SIDS (2006)). No report on fertility was obtained.
8 Specific target organ toxicity - Single exposure Category 3 (respiratory tract irritation, narcotic effects)


Warning
H335
H336
P304+P340
P403+P233
P261
P271
P312
P405
P501
Because nasal and respiratory tract irritation was observed at the concentration (3.43 mg/L) within the guidance value range in rats in the inhalation route (ACGIH (7th, 2001)), it was classified in Category 3 (respiratory tract irritation). Because in an oral administration test with rats, passiveness, ataxia, and salivation were found at the concentrations (710-2,000 mg/kg) within the guidance value range (SIDS (2006)), it was classified in Category 3 (narcotic effects).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory organs)


Danger
H372 P260
P264
P270
P314
P501
It is described that after 4-week inhalation exposure to the vapour of this substance in experimental animals (rats, mice, rabbits, dogs), irritation changes in the nasal mucosa and respiratory organs were observed at the concentrations (converted guidance value: 0.006 mg/L/6 hours or less) (SIDS (2006), ACGIH (7th, 2001), DFGOT vol.16 (2001)). Therefore, it was classified in Category 1 (respiratory organs).
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2
-
-
H401 P273
P501
From 96-hour LC50 = 3.1 mg/L for fish (Pimephales promelas) (SIDS, 2006), it was classified in Category 2.
11 Hazardous to the aquatic environment (Long-term) Not classified
-
-
- - If chronic toxicity data are used, then it is classified as "Not classified" due to rapid degradability (a degradation rate by BOD: 83% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2001)), and 72-hour NOEC (r) = 5 mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 2006).
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to rapid degradability (a degradation rate by BOD: 83% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2001)), and a low bioaccumulation estimate (log Kow = 0.35 (SIDS, 2006)) despite 96-hour LC50 = 3.1 mg/L for fish (Pimephales promelas) (SIDS, 2006).
From the above results, it was classified as "Not classified."
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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