GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 111-18-2
Chemical Name N,N,N',N'-Tetramethyl-1,6-hexamethylenediamine
Substance ID 25A0019
Classification year (FY) FY2013
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Category 4
-
Warning
H227 P370+P378
P403+P235
P210
P280
P501
From data: a flash point of 81 deg C (open cup) (NITE Chemical Risk Information Platform (NITE-CHRIP) (Access on August 2013)), it is estimated that it will also fall within 60-93 deg C in the prescribed closed-cup method, therefore it was classified in Category 4.
7 Flammable solid Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 180 deg C (NITE Chemical Risk Information Platform (NITE-CHRIP) (Access on August 2013)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Organic compounds containing no oxygen, fluorine or chlorine.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule.
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, there is a report on an LD50 value of 316-464 mg/kg for rats (ECHA (Access on October 2013)). This information was not used for classification because it is from the information source outside the List.
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, there is a report on an LD50 value of > 400 mg/kg for rabbits (ECHA (Access on October 2013)). This information was not used for classification because it is from the information source outside the List.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- - Classification not possible due to lack of data.
3 Serious eye damage/eye irritation Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, as for in vitro, there is information that it was negative in all of a bacterial reverse mutation test, a gene mutation test (hgprt gene locus) with cultured mammalian cells, and a micronucleus test with cultured V79 cells of Chinese hamsters (ECHA (Access on September 2013)). This information was not used for classification because it is from the information source outside the List.
6 Carcinogenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, in ECHA (Access on October 2013), in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) with rats in the oral route (gavage), reproductive toxicity was not observed at the doses where general toxicity was found in parent animals. Furthermore, likewise in NITE Chemical Risk Information Platform (NITE-CHRIP), and Safety Test (Ministry of Economy, Trade and Industry (METI) (Access on October 2013)), in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) with rats in the oral route (gavage), reproductive toxicity was not observed at the dose where general toxicity was found in parent animals. The above information was not used for classification because it is from the information source outside the List.
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, in ECHA (Access on October 2013), there is a report on transient dyspnea, apathy, staggering, spastic gait, etc. in gavage administration to rats at concentrations (215-464 mg/kg) within the guidance value ranges for Category 1-2. This information was not used for classification because it is from the information source outside the List.
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, the following test results are reported in NITE Chemical Risk Information Platform (NITE-CHRIP), Safety Test (Ministry of Economy, Trade and Industry (METI) (Access on October 2013)) and ECHA (Access on October 2013). In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test in which rats were dosed by gavage for 42 days from 14 days before mating for males and 42-47 days from 14 days before mating for females, vacuolated bronchial epithelium in the lung was observed at the dose (23.3 mg/kg/day (converted guidance value)) corresponding to Category 2 (NITE Chemical Risk Information Platform (NITE-CHRIP) (Access on October 2013)). In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test in which rats were dosed by gavage (males: for 30 days from 14 days before mating, females: from 14 days before mating to day 4 of lactation), decreased eosinophil counts were found at the dose (25 mg/kg/day (converted guidance value)) corresponding to Category 2, but this was thought to be effects of unspecific stress (ECHA (Access on October 2013)). The above information was not used for classification because it is from the information source outside the List.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3
-
-
H402 P273
P501
From 72-hour ErC50 = 71 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2008)), it was classified in Category 3.
11 Hazardous to the aquatic environment (Long-term) Category 3
-
-
H412 P273
P501
If chronic toxicity data are used, then it is classified as "Not classified" due to being not rapidly degradable (a degradation rate by BOD: 1% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2005)), and 72-hour NOEC (r) = 9.4 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2008)).
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 due to being not rapidly degradable (a degradation rate by BOD: 1% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2005)), and 48-hour EC50 = 78 mg/L for crustacea (Daphnia magna) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2008)).
By drawing a comparison between the above results, it was classified in Category 3.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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