Item | Information |
---|---|
CAS RN | 126-58-9 |
Chemical Name | Dipentaerythritol |
Substance ID | 25A0026 |
Classification year (FY) | FY2013 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance by the Japanese Government (July, 2013) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
7 | Flammable solid | Classification not possible |
- |
- | - | No data available. |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of about 370 deg C (NITE Chemical Risk Information Platform (NITE-CHRIP) (Access on August 2013)). |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
14 | Oxidizing solids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | It was classified as "Not classified" based on a report on an LD50 value of > 2,000 mg/kg for rats (SIDS (2002)). |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, it is described in SIDS (2002) that skin irritation was observed in one out of 26 workers formulating radiation drying printing ink. However, because the details are unknown, it was classified as "Classification not possible." |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, it is described in SIDS (2002) that sensitization and cross-sensitization were observed in four out of 26 workers handling this substance. However, because the details are unknown, it was classified as "Classification not possible." |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Thre are no in vivo data, and as for in vitro, it was negative in a bacterial reverse mutation test and a chromosomal aberration test with cultured mammalian cells (SIDS (2002)). Besides, there is information (negative in an in vitro mouse lymphoma test) in ECHA (Access on October 2013). This information was not used for classification because it is from the information source outside the List. |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats in the oral route, no effects on fertility were observed (SIDS (2002)). Because it is the result of a screening test, it was judged to be "Classification not possible." |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, after gavage administration to rats, limited piloerection and abnormal body carriage were observed within the guidance value range (2,000 mg/kg) (SIDS (2002)). |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | It is described that in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test in which rats were dosed by gavage at the limit dose (1,000 mg/kg/day) for 4 to 6 weeks, signs of toxicity were not observed in males and females (SIDS (2002)). Therefore, it corresponds to "Not classified" in the oral route. However, because of no toxicity information on the other routes, it was classified as "Classification not possible" due to lack of data. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Not classified |
- |
- | - | From 24-72-hour EC50 > 100 mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 2002), 48-hour EC50 > 100 mg/L for crustacea (Daphnia magna) (SIDS, 2002), and 96-hour LC50 > 100 mg/L for fish (Oncorhynchus mykiss) (SIDS, 2002), was classified as "Not classified." |
11 | Hazardous to the aquatic environment (Long-term) | Not classified |
- |
- | - |
If chronic toxicity data are used, then it is classified as "Not classified" due to 24-72-hour EC50 > 100 mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 2002), although it is not rapidly degradable (a degradation rate by BOD: 3% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2002)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" because it corresponds to "Not classified" in acute toxicity for both crustacea and fish, and it is not water-insoluble (water solubility = 2.4 g/L, GESTIS, 2013). From the above results, it was classified as "Not classified." |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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