Item | Information |
---|---|
CAS RN | 7580-85-0 |
Chemical Name | Ethylene glycol mono-tert-butyl ether |
Substance ID | 25A0040 |
Classification year (FY) | FY2013 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance by the Japanese Government (July, 2013) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 3 |
Warning |
H226 |
P303+P361+P353
P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
From data: a flash point of 55 deg C (unknown test method) (SIDS (2004)), it will be also <= 60 deg C in the prescribed closed-cup method, therefore it was classified in Category 3. |
7 | Flammable solid | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | It was classified as "Not classified" based on reports on an LD50 value of > 2,000 mg/kg for rats (Environmental Risk Assessment for Chemical Substances vol. 9, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2011), JECDB (Access on October 2013), SIDS (2005)). |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | It was classified as "Not classified" based on a report on an LCLo value (5 hours) for rats of 2,400 ppm (11,592 mg/m3) (converted 4-hour equivalent LCLo value: 14.49 mg/L) (Environmental Risk Assessment for Chemical Substances vol. 9, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2011)). Besides, because the LCLo value is higher than the saturated vapour pressure concentration (4.89 mg/L), a reference value in the unit of mg/L was applied as mist. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There are no in vivo data, and as for in vitro, it was negative in a bacterial reverse mutation test and a chromosomal aberration test with cultured mammalian cells (JECDB (Access on October 2013)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. No fertility effects were observed in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats in the oral route (gavage) (JECDB (Access on October 2013), Environmental Risk Assessment for Chemical Substances vol. 9, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2011)). Because it is a result of a screening test, and sufficient data on developmental toxicity were not obtained, it was classified as "Classification not possible." |
8 | Specific target organ toxicity - Single exposure | Category 3 (Narcotic effects) |
Warning |
H336 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
In a gavage administration test with rats, reversible chromaturia, abnormal gait, decreased locomotor activity, prone position, irregular respiration, etc. were observed at the concentrations (500-2,000 mg/kg) within the guidance value range (JECDB (Access on October 2013)). From the above findings, it was classified in Category 3 (narcotic effects). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (haemal system) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats by gavage administration, anemia findings, increased extramedullary hematopoiesis and hemosiderin deposition in the liver and spleen and hemosiderin deposition in the tubular epithelium in the kidney were observed at or above 20 mg/kg/day (converted guidance value: 8.2-10 mg/kg/day (corresponding to Category 1)), and increased erythrocytic hematopoiesis in the bone marrow was also found at 100 mg/kg/day (converted guidance value: 41-52 mg/kg/day) (JECDB (Access on October 2013)). Both hemosiderin deposition in the liver, spleen, and kidney and increased erythrocytic hematopoiesis in the bone marrow were thought to be secondary effects of anemia, and it was judged to be inappropriate to adopt these organs as target organs. Therefore, it was classified in Category 1 (blood system). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Not classified |
- |
- | - | From 72-hour ErC50 > 866 mg/L for algae (Desmodesmus subspicatus) (SIDS, 2005), 48-hour EC50 > 891 mg/L for crustacea (Daphnia magna) (SIDS, 2005), and 96-hour LC50 > 100 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 2000)), it was classified as "Not classified." |
11 | Hazardous to the aquatic environment (Long-term) | Not classified |
- |
- | - |
If chronic toxicity data are used, then it is classified as "Not classified" due to 72-hour NOEC (r) = 23 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 2000)) although it is not rapidly degradable (not readily degradable, a degradation rate by BOD: 6% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2001; SIDS, 2005)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" because it corresponds to "Not classified" in acute toxicity for fish, and it is not water-insoluble (water solubility > 100 g/L, SIDS, 2005). From the above results, it was classified as "Not classified." |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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