Item | Information |
---|---|
CAS RN | 26444-49-5 |
Chemical Name | Cresyl diphenyl phosphate |
Substance ID | 25A0044 |
Classification year (FY) | FY2013 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance by the Japanese Government (July, 2013) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Not classified |
- |
- | - | From a flash point of 232 deg C (closed cup) (HSDB (Access on October 2013)) above 93 deg C, it was classified as "Not classified." |
7 | Flammable solid | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties (P-O of phosphoric acid is not self-reactive). |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | From information on water solubility: 2.4 mg/L (25 deg C) (HSDB (Access on October 2013)), it is recognized that it does not react vigorously with water. |
13 | Oxidizing liquids | Classification not possible |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than carbon or hydrogen (P). However, the classification is not possible due to no data. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | It was classified as "Not classified" based on a report on an LD50 value of 6,400 mg/kg for rats (SIDS (2002)). |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | It was classified as "Not classified" based on a report on an LD50 value of > 5,000 mg/kg for rabbits (SIDS (2002)). |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Because in SIDS (2002), there are contradicting results of severe irritation and no irritation in skin irritation tests with rabbits (OECD TG 404), it was classified as "Classification not possible" due to lack of data. |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 |
P305+P351+P338
P337+P313 P264 P280 |
It was classified in Category 2 because it is described in SIDS (2002) that severe irritation was observed in an eye irritation test with rabbits (OECD TG 405). |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. It is described in SIDS (2002) that no sensitization was observed in patch tests in humans and rats. However, because the test details are unknown, it was classified as "Classification not possible." |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a micronucleus test with mouse bone marrow cells. As for in vitro, it was negative in a bacterial reverse mutation test and positive in a chromosomal aberration test with cultured mammalian cells. Because it was negative in an in-vivo micronucleus test, it is judged to be not clastogenic. Besides, in SIDS, this substance was assessed to be not genotoxic (SIDS (2002)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
7 | Reproductive toxicity | Category 2 |
Warning |
H361 |
P308+P313
P201 P202 P280 P405 P501 |
In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats in the oral route (gavage), parental toxicity (enlargement and cortical vacuolation of the adrenal gland (males and females), a decrease in food consumption, an increase in total cholesterol, a decrease in cholinesterase activities, enlargement of the liver (males), suppression of body weight gains, histopathological changes in the liver, kidney, and thymus (females)) were observed at 60 mg/kg bw/day, and reproductive effects (decreases in a fertility index and an implantation index) were found at 300 mg/kg bw/day, which were thought to be caused by dysspermatogenesis in males (SIDS (2002), JECDB (Access on October 2013), Environmental Risk Assessment for Chemical Substances vol. 9, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2011)). Because reproductive effects were observed at the dose where parental toxicity was seen, it was classified in Category 2. Besides, no reports on developmental toxicity were obtained. |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (liver, kidney, adrenal gland, thymus) |
Warning |
H373 |
P260
P314 P501 |
In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats by gavage administration, effects of the adrenal gland (enlargement and cortical vacuolation), liver (enlargement and pale and clear cells in hepatocytes), kidney (eosinophilization in the proximal tubule epithelium), and thymus (atrophy) were observed at the dose (30 mg/kg/day (converted guidance value)) corresponding to Category 2 (SIDS (2002), JECDB (Access on October 2013), HSDB (Access on October 2013)). Therefore, it was classified in Category 2 (liver, kidney, adrenal gland, thymus). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 |
Warning |
H400 |
P273
P391 P501 |
From 72-hour EbC50 = 0.99 mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 2002), it was classified in Category 1. |
11 | Hazardous to the aquatic environment (Long-term) | Category 2 |
- |
H411 |
P273
P391 P501 |
If chronic toxicity data are used, then it is classified in Category 2 due to being not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1996)), and 21-day NOEC (reproduction) = 0.12 mg/L for crustacea (Daphnia magna) (SIDS, 2002). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1996)), and 96-hour LC50 = 1.3 mg/L for fish (Oryzias latipes) (SIDS, 2002). From the above results, it was classified in Category 2. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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