GHS Classification Result

日本語で表示



GENERAL INFORMATION
Item Information
CAS RN 144-55-8
Chemical Name Sodium hydrogen carbonate
Substance ID 25A0045
Classification year (FY) FY2013
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Solid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Solid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Solid (GHS definition)
6 Flammable liquids Not applicable
-
-
- - Solid (GHS definition)
7 Flammable solid Not classified
-
-
- - Not combustible (ICSC (2004)).
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not applicable
-
-
- - Solid (GHS definition)
10 Pyrophoric solids Not classified
-
-
- - Not combustible (ICSC (2004)).
11 Self-heating substances and mixtures Not classified
-
-
- - Not combustible (ICSC (2004)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified
-
-
- - From information on water solubility: 8.7 g/100 g (20 deg C) (HSDB (Access on October 2013)), it is recognized that it does not react vigorously with water.
13 Oxidizing liquids Not applicable
-
-
- - Solid (GHS definition)
14 Oxidizing solids Not classified
-
-
- - It is not oxidizing (SIDS (2004)).
15 Organic peroxides Not applicable
-
-
- - It is an inorganic compound.
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- - It was classified as "Not classified" based on a report on LD50 values for rats of > 4,000 mg/kg, 7,334 mg/kg, and 4,220-8,290 mg/kg (SIDS (2004)).
1 Acute toxicity (Dermal) Not classified
-
-
- - It was classified as "Not classified" based on a report on an LD50 value of > 2,000 mg/kg for rats (Japan Crop Protection Association (1996)).
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Not classified
-
-
- - It was classified as "Not classified" based on a report on an LC50 value for rats of > 4.74 mg/L (4.5 hours) (converted 4-hour equivalent value: 5.33 mg/L) (SIDS (2004)). Besides, it was regarded as a test on dust based on the description of the test methods, and a reference value in the unit of mg/L was applied.
2 Skin corrosion/irritation Not classified
-
-
- - Because a test with rabbits according to the test guideline resulted in extremely slight irritation (primary skin irritation score = 0.3) (SIDS (2004)), it was classified as "Not classified" (Category 3 in UN GHS classification).
3 Serious eye damage/eye irritation Not classified
-
-
- - Five data are reported in SIDS (2004), and it is reported that in a reliable test according to the EPA TSCA guideline, a 24-hour score (MMTS) was 8.3 (slight irritation). Therefore, it was classified as "Not classified" (Category 3 in UN GHS classification).
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data. There are no in vivo data, and as for in vitro, it was negative in a bacterial reverse mutation test and a chromosomal aberration test with cultured mammalian cells (SIDS (2004)).
6 Carcinogenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, no developmental toxicity was observed in developmental toxicity tests with mice, rats, with rabbits in the oral route (gavage) (SIDS (2004)). No reports on fertility were obtained.
8 Specific target organ toxicity - Single exposure Not classified
-
-
- - All tests reported in the oral route used doses above the guidance value range (3,000-9,000 mg/kg), and the animals showed transient symptoms such as hypoactivity, staggered gait, and shallow breathing but recovered later (SIDS (2004), Japan Crop Protection Association (1996)). Therefore, it was classified in Category 3 (narcotic effects). Besides, in inhalation exposure (mist) in rats, transient reduced movement and hunched posture, and ocular and/or nasal discharge were observed at the concentration (4.74 mg/L) near the upper limit of the guidance value range, but these were reversible. As for the dermal route, it is described that in a test with rats exposed to the undiluted substance at the highest dose (2,000 mg/kg) within the guidance value range, no death or toxic signs were observed (Japan Crop Protection Association (1996)). From the above results, it was classified as "Not classified."
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - Because it is described in SIDS (2004) that this substance is recognized as GRAS (Generally Recognized As Safe) by the U.S. Food and Drug Administration (FDA), it is thought to correspond to "Not classified" in the oral route. However, because of no toxicity information on the other routes, it was classified as "Classification not possible" due to lack of data.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified
-
-
- - From 48-hour EC50 = 1020 mg/L for crustacea (Ceriodaphnia dubia) (SIDS, 2004), and 96-hour LC50 = 7700 mg/L for fish (Oncorhynchus mykiss) (SIDS, 2004), it was classified as "Not classified."
11 Hazardous to the aquatic environment (Long-term) Not classified
-
-
- - If chronic toxicity data are used, then it is classified as "Not classified" due to 21-day NOEC (reproduction, survival) > 576 mg/L for crustacea (Daphnia magna) (SIDS, 2004), despite unknown behavior of the inorganic compound in water.
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to 96-hour LC50 = 7700 mg/L for fish (Oncorhynchus mykiss) (SIDS, 2004), despite unknown behavior of the inorganic compound in water.
From the above results, it was classified as "Not classified."
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

To GHS Information