GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 836-30-6
Chemical Name 4-Nitrodiphenylamine
Substance ID 25A0048
Classification year (FY) FY2013
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not classified
-
-
- - There is a chemical group associated with explosive properties (nitro group) in the molecule, but the result of the oxygen balance calculation (calculated value: -202) is less than the criteria of -200.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Solid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Solid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Solid (GHS definition)
6 Flammable liquids Not applicable
-
-
- - Solid (GHS definition)
7 Flammable solid Classification not possible
-
-
- - No data available.
8 Self-reactive substances and mixtures Classification not possible
-
-
- - There is a chemical group associated with explosive properties (nitro group) in the molecule, but the classification is not possible due to no data.
9 Pyrophoric liquids Not applicable
-
-
- - Solid (GHS definition)
10 Pyrophoric solids Classification not possible
-
-
- - No data available.
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - Solid (GHS definition)
14 Oxidizing solids Classification not possible
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than carbon or hydrogen (N). However, the classification is not possible due to no data.
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule.
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- - It was classified as "Not classified" based on a report on an LD50 value of > 7,940 mg/kg for rats (SIDS (2004)).
1 Acute toxicity (Dermal) Not classified
-
-
- - It was classified as "Not classified" based on a report on an LD50 value of > 7,940 mg/kg for rats (SIDS (2004)).
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- - Solid (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Not classified
-
-
- - It was classified as "Not classified" based on the description in SIDS (2004) that there was no irritation in a 24-hour exposure test with rabbits.
3 Serious eye damage/eye irritation Not classified
-
-
- - It was classified as "Not classified" because only slight irritation was observed in an eye irritation /corrosion test (according to FHSA) with rabbits in SIDS (2004), and the result of no irritation was obtained in IUCLID (2000).
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a chromosomal aberration test with rat bone marrow cells and an in-vivo unscheduled DNA synthesis test with primary rat hepatocytes, and as for in vitro, it was negative in a bacterial reverse mutation test and a chromosomal aberration test and a gene mutation test with cultured mammalian cells (SIDS (2004), IUCLID (2000)). Therefore, this substance was judged to be not mutagenic.
6 Carcinogenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, in developmental toxicity tests with rats in the oral route (gavage), no developmental toxicity was observed (IUCLID (2000)), or developmental toxicity (decreased fetal body weights, skeletal variations) was found but no malformations were seen at or above 1,000 mg/kg bw/day where moderate to severe maternal toxicity (death, reduced weight gains, no-feces, decreased feces, etc.) was observed (SIDS (2004), IUCLID (2000)). the above developmental toxicity was not used for classification because it was slight. Furthermore, because no report on fertility was obtained, it was classified as "Classification not possible."
8 Specific target organ toxicity - Single exposure Classification not possible
-
-
- - Classification not possible due to lack of data.
9 Specific target organ toxicity - Repeated exposure Category 1 (haemal system), Category 2 (kidney)


Danger
Warning
H372
H373
P260
P264
P270
P314
P501
It is described that in a 90-day diet administration test with rats, effects on the blood system (increased reticulocytes and methemoglobin, decreases in RBC counts, hematocrit, and hemoglobin), kidney (discoloration, nephropathy of the cortex and medulla) and spleen (congestion, hemosiderin deposition) were observed at the dose (2,000 ppm: corresponding to 100 mg/kg/day) of the upper limit for Category 2 (SIDS (2004)), and in a test with rats exposed to this substance (dust) by inhalation for 21 days, respiratory irritation and increased methemoglobin were found from the concentration (converted guidance value: 0.0067 mg/L/6 hours) corresponding to Category 1 (SIDS (2004)). Because the findings in the spleen in the diet administration test were thought to be secondary effects of anemia, the spleen was not taken as the target organ. Furthermore, as for respiratory irritation in the inhalation exposure test, the details of the sites and changes are unknown, including whether these were from observation of symptoms or pathological examinations. Therefore, it was judged to be inappropriate to adopt the respiratory organs as the target organs. Because methemoglobin was a finding indicative severe blood toxicity, it was classified in Category 1 (blood system), Category 2 (kidney).
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1


Warning
H400 P273
P391
P501
From 48-hour EC50 = 1 mg/L for crustacea (Daphnia magna) (SIDS, 2004), it was classified in Category 1.
11 Hazardous to the aquatic environment (Long-term) Category 1


Warning
H410 P273
P391
P501
Reliable chronic toxicity data were not obtained. It was classified in Category 1 because it is not rapidly degradable (BIOWIN), and it was classified in Category 1 in acute toxicity.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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