GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 7791-25-5
Chemical Name Sulfuryl chloride
Substance ID 25A0052
Classification year (FY) FY2013
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised New
Classification result in other fiscal year  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Not classified
-
-
- - Not combustible (ICSC (1998)).
7 Flammable solid Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not classified
-
-
- - There is a chemical group associated with self-reactive properties (halogenated sulfonyl group) in the molecule, but because it is classified in Division 6.1 (UN1834) in UNRTDG, it is considered to be not applicable to hazards of the high est precedence, self-reactive substances.
9 Pyrophoric liquids Not classified
-
-
- - Not combustible (ICSC (1998)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Not classified
-
-
- - Not combustible (ICSC (1998)).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Classification not possible
-
-
- - It is an inorganic compound containing oxygen and chlorine, but the classification is not possible due to no data.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - It is an inorganic compound.
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Classification not possible due to lack of data.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 2


Danger
H330 P304+P340
P403+P233
P260
P271
P284
P310
P320
P405
P501
It was classified in Category 2 based on a report on an LC50 value (4 hours) of 878 mg/m3 (= 159 ppmV) for rats (SIDS (2005)). Besides, because the LC50 value is lower than 90% of the saturated vapour pressure concentration (146,100 ppmV), and it is described as a test with vapour, a reference value in the unit of ppmV was applied as a vapour with little mist.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
It is described in SIDS (2005) that it can be concluded that this substance is corrosive to the skin based on the chemical nature of the substance itself and based on information on its hydrolysis products. Furthermore, this substance is classified "C; R34" in EU DSD classification and "Skin Corr. 1B H314" in EU CLP classification. Based on the above information, it was classified in Category 1.
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
It is described in SIDS (2005) that it can be concluded that this substance is corrosive to the eyes based on the chemical nature of the substance itself and based on information regarding its hydrolysis products. Furthermore, it is described in HSDB (Access on October 2013) that the vapour of this substance is extremely irritating to the eyes. Based on the above information, it was classified in Category 1.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. There are no in vivo data on this substance. As for in vitro, it was negative in a bacterial reverse mutation test, and there are no other in vitro data. This substance generates hydrochloric acid and sulfuric acid by hydrolysis. A drop in pH is known to cause chromosomal aberrations and DNA damage. This substance enters the body and hydrolyzes to form acids, which decrease pH and may cause cytotoxicity and irritation/corrosion, and chromosomal aberrations and DNA damage at the local site of exposure. However, it is unlikely that systemic changes in pH would occur that are sufficient in magnitude to induce this effect in tissues or organs which are distant from the site exposed to this substance (SIDS (2005)). Furthermore, at low and non-irritating concentrations, chloride anion and sulfate anion are not mutagenic. From the above, although in vivo and in vitro test data are lacking, it does not prevent this substance from being assessed to be not genotoxic from the viewpoint of the chemical nature of the substance mentioned above (SIDS (2005)).
6 Carcinogenicity Classification not possible
-
-
- - There are no carcinogenicity test data on this substance (SIDS (2005)). Besides, hydrochloric acid and sulfuric acid, the hydrolysis products of this substance, gave no clear indications for an increased tumor incidence in experimental animals by lifetime exposure (SIDS (2005)). On the other hand, as for humans, epidemiological studies suggested a relationship between exposure to strong inorganic acid mists containing sulfuric acid and an increased incidence of laryngeal cancer. It is concluded in IARC (1992) that occupational exposure to strong-inorganic-acid mists containing sulfuric acid is carcinogenic to humans (Group 1). Because there is no carcinogenicity information directly related to this substance, it was classified as "Classification not possible."
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory organs)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
In humans, irritation of the respiratory tract and pulmonary edema are reported after exposure to this substance (SIDS (2005)). Furthermore, in a test with rats exposed to the vapour of this substance by inhalation, reddish exudates from the nose, reduced body weights, etc. are reported within the range for Category 1 (0.04-1.5 mg/L). From the above results, it was classified in Category 1 (respiratory organs).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory organs)


Danger
H372 P260
P264
P270
P314
P501
In a test with rats exposed to the vapour of this substance for 14 days by inhalation, death (males 2/10 animals), necrotic bronchopneumonia, purulent rhinitis, and atrophy in the thymus were observed at the concentration (110 mg/m3 (converted guidance value: 0.012 mg/L/6 hours/day)) within the guidance value range for Category 1 (SIDS (2005), IUCLID (2000), HSDB (Access on October 2013)). Death and atrophy in the thymus were thought to be caused by severe effects on the respiratory organs, and it was classified in Category 1 (respiratory organs).
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Classification not possible
-
-
- - No data available.
11 Hazardous to the aquatic environment (Long-term) Classification not possible
-
-
- - No data available.
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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