Item | Information |
---|---|
CAS RN | 7791-25-5 |
Chemical Name | Sulfuryl chloride |
Substance ID | 25A0052 |
Classification year (FY) | FY2013 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | New |
Classification result in other fiscal year | |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance by the Japanese Government (July, 2013) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Not classified |
- |
- | - | Not combustible (ICSC (1998)). |
7 | Flammable solid | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not classified |
- |
- | - | There is a chemical group associated with self-reactive properties (halogenated sulfonyl group) in the molecule, but because it is classified in Division 6.1 (UN1834) in UNRTDG, it is considered to be not applicable to hazards of the high est precedence, self-reactive substances. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | Not combustible (ICSC (1998)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | Not combustible (ICSC (1998)). |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Classification not possible |
- |
- | - | It is an inorganic compound containing oxygen and chlorine, but the classification is not possible due to no data. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic compound. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Category 2 |
Danger |
H330 |
P304+P340
P403+P233 P260 P271 P284 P310 P320 P405 P501 |
It was classified in Category 2 based on a report on an LC50 value (4 hours) of 878 mg/m3 (= 159 ppmV) for rats (SIDS (2005)). Besides, because the LC50 value is lower than 90% of the saturated vapour pressure concentration (146,100 ppmV), and it is described as a test with vapour, a reference value in the unit of ppmV was applied as a vapour with little mist. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 |
P301+P330+P331
P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
It is described in SIDS (2005) that it can be concluded that this substance is corrosive to the skin based on the chemical nature of the substance itself and based on information on its hydrolysis products. Furthermore, this substance is classified "C; R34" in EU DSD classification and "Skin Corr. 1B H314" in EU CLP classification. Based on the above information, it was classified in Category 1. |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
It is described in SIDS (2005) that it can be concluded that this substance is corrosive to the eyes based on the chemical nature of the substance itself and based on information regarding its hydrolysis products. Furthermore, it is described in HSDB (Access on October 2013) that the vapour of this substance is extremely irritating to the eyes. Based on the above information, it was classified in Category 1. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. There are no in vivo data on this substance. As for in vitro, it was negative in a bacterial reverse mutation test, and there are no other in vitro data. This substance generates hydrochloric acid and sulfuric acid by hydrolysis. A drop in pH is known to cause chromosomal aberrations and DNA damage. This substance enters the body and hydrolyzes to form acids, which decrease pH and may cause cytotoxicity and irritation/corrosion, and chromosomal aberrations and DNA damage at the local site of exposure. However, it is unlikely that systemic changes in pH would occur that are sufficient in magnitude to induce this effect in tissues or organs which are distant from the site exposed to this substance (SIDS (2005)). Furthermore, at low and non-irritating concentrations, chloride anion and sulfate anion are not mutagenic. From the above, although in vivo and in vitro test data are lacking, it does not prevent this substance from being assessed to be not genotoxic from the viewpoint of the chemical nature of the substance mentioned above (SIDS (2005)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | There are no carcinogenicity test data on this substance (SIDS (2005)). Besides, hydrochloric acid and sulfuric acid, the hydrolysis products of this substance, gave no clear indications for an increased tumor incidence in experimental animals by lifetime exposure (SIDS (2005)). On the other hand, as for humans, epidemiological studies suggested a relationship between exposure to strong inorganic acid mists containing sulfuric acid and an increased incidence of laryngeal cancer. It is concluded in IARC (1992) that occupational exposure to strong-inorganic-acid mists containing sulfuric acid is carcinogenic to humans (Group 1). Because there is no carcinogenicity information directly related to this substance, it was classified as "Classification not possible." |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory organs) |
Danger |
H370 |
P308+P311
P260 P264 P270 P321 P405 P501 |
In humans, irritation of the respiratory tract and pulmonary edema are reported after exposure to this substance (SIDS (2005)). Furthermore, in a test with rats exposed to the vapour of this substance by inhalation, reddish exudates from the nose, reduced body weights, etc. are reported within the range for Category 1 (0.04-1.5 mg/L). From the above results, it was classified in Category 1 (respiratory organs). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
In a test with rats exposed to the vapour of this substance for 14 days by inhalation, death (males 2/10 animals), necrotic bronchopneumonia, purulent rhinitis, and atrophy in the thymus were observed at the concentration (110 mg/m3 (converted guidance value: 0.012 mg/L/6 hours/day)) within the guidance value range for Category 1 (SIDS (2005), IUCLID (2000), HSDB (Access on October 2013)). Death and atrophy in the thymus were thought to be caused by severe effects on the respiratory organs, and it was classified in Category 1 (respiratory organs). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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