NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	7791-20-0
Chemical Name	Nickel chloride hexahydrate
Substance ID	25A0073
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solid	Not classified	- -	-	-	It is estimated to be not combustible. Besides, nickel chloride anhydrate (CAS RN 7718-54-9) is not combustible (HSDB (Access on October 2013)).
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated to be not combustible. Besides, nickel chloride anhydrate (CAS RN 7718-54-9) is not combustible (HSDB (Access on October 2013)).
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is estimated to be not combustible. Besides, nickel chloride anhydrate (CAS RN 7718-54-9) is not combustible (HSDB (Access on October 2013)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	From information: water solubility of 642 g/L (20 deg C) (GESTIS (Access on August 2013)), it is recognized that it does not react vigorously with water.
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	- -	-	-	It is an inorganic compound, the chlorine of which is chemically bonded to the element other than hydrogen (Ni). However, this does not contribute to oxidization because it is ionically bonded.
15	Organic peroxides	Not applicable	- -	-	-	It is an inorganic compound.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	There are reports on four LD50 values for rats; 175 mg/kg (males) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ECETOC TR33 (1989)) and 210 mg/kg (females) (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ECETOC TR33 (1989)) corresponded to Category 3, and 430 mg/kg (males) (ECETOC TR33 (1989)) and 529 mg/kg (females) (ECETOC TR33 (1989)) corresponded to Category 4. Because of the same numbers, by adopting the category corresponding to the minimum LD50 value, it was classified in Category 3. Besides, data in ECETOC TR33 (1989) have no description of crystallization water, but it was judged to be data on the hexahydrate from the conversion rate of LD50 values to nickel and was used for classification. Besides, there is a report on LD50 values for nickel chloride anhydrate (CAS RN 7718-54-9) of 430 mg/kg (males) and 529 mg/kg (females) (corresponding to Category 4) for rats (ECETOC TR33 (1989)).
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there are no animal test data on nickel chloride anhydrate (CAS RN 7718-54-9), but it was classified in Category 2 because it is described that the threshold concentrations of irritation were 1% with occlusion and 10% without occlusion for aqueous solutions of nickel chloride in humans (EHC 108 (1991)), and it was classified in "Xi; R38" in EU DSD classification and "Skin Irrit. 2 H315" in EU CLP classification.
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	Nickel and inorganic nickel compounds are classified in occupational sensitizers to the airway Group 2 in the Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2013), "R42" in EU DSD classification, and "Resp. Sens. 1 H334" in EU CLP classification. From the above, it was classified in Category 1.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	It is described in the Initial Risk Assessment Report (NITE, CERI, NEDO, 2008) that among six kinds of skin sensitization tests with guinea pigs (maximization test, single injection adjuvant test, modified Draize test, split adjuvant test, Polak test, and gross test), nickel chloride was positive in a maximization test and a Polak test, and it depended on a test method whether skin sensitization occurred. Nickel and inorganic nickel compounds are classified in occupational skin sensitizers Group 1 in the Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2013), "R43" in EU DSD classification, and "Skin Sens. 1 H317" in EU CLP classification. From the above information, it was classified in Category 1.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. As for in vivo, positive results were found in chromosomal aberration tests with bone marrow cells of mice and hamsters, a micronucleus test with mouse bone marrow cells, a DNA damage test with mouse leukocytes, and a DNA cleavage test with rat liver (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), but it was negative in a micronucleus test with mouse bone marrow cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). And it is reported that nickel sulfate hexahydrate, nickel chloride hexahydrate, and nickel oxide (III) were all negative in an in-vivo micronucleus test (Mutat. Res., 1997). As for in vitro, it was negative or positive in reverse mutation tests and positive in a gene mutation test and a chromosomal aberration test with cultured mammalian cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ECETOC TR33 (1989)). From the above, a conclusion cannot be drawn because there are both positive and negative in vivo results, and the classification is not possible due to lack of data. Besides, nickel chloride anhydrate (CAS RN 7718-54-9) was classified as "Not classified."
6	Carcinogenicity	Category 1A	Danger	H350	P308+P313 P201 P202 P280 P405 P501	Nickel sulfate, the anhydrate of this substance, are classified in Group 1 as nickel compounds by IARC (IARC (2012)), "Carc. Cat. 1; R45" in EU DSD classification, "Carc.1A H350i" in EU CLP classification, Group 2B by the Japan Society for Occupational Health (JSOH) (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health, 2013)), K by NTP (NTP (2002)), and A4 as soluble nickel compounds by ACGIH (ACGIH (1996)). Besides, it is described in NTP TR454 (1996) that there was no tumor increase in both 2-year inhalation tests with rats and mice. Among the above information, by giving priority to the year issued, the classification in IARC (2012) was adopted, and it was classified in Category 1A.
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	In a two-generation reproductive toxicity test and a one-generation reproductive toxicity test with rats in the oral route (drinking water), death of fetuses was observed at the dose lower than the dose where parental toxicity was seen (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). Therefore, it was classified in Category 1B.
8	Specific target organ toxicity - Single exposure	-	- -	-	-	Classification not possible due to lack of data. Besides, for nickel chloride anhydrate (CAS RN 7718-54-9), it is described that in an oral administration test with rats, they showed excitation and increased motor activity followed by depression of the nervous system at 430 mg/kg (males) and 529 mg/kg (females) corresponding to Category 2 (ECETOC TR33 (1989)), and the substance was classified in Category 2 (nervous system).
9	Specific target organ toxicity - Repeated exposure	Category 2 (lung)	Warning	H373	P260 P314 P501	In a 90-day gavage administration test with rats, death cases were observed dose-dependently (mortality: 3.3, 10, and 100% for low, middle, and high doses for both males and females) from the dose (20 mg/kg/day) within the guidance value range for Category 2, and lethargy and irregular respiration were found as symptoms before death. In a middle dose group (equivalent to 140 mg/kg/day), inflammation in the lung and atrophy of the alveolar epithelial cells were seen (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), and it was thought that the lung was the target organ, and respiratory depression from adverse effects on the lung caused the symptoms that occurred and death. Therefore, it was classified in Category 2 (lung).
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 3	- -	H402	P273 P501	From 96-hour LC50 = 11 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2006)), it was classified in Category 3.
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	Although appropriate data on rapid degradability were not obtained, it was classified as "Not classified" due to NOEC = 1.1 mg/L for fish (Oryzias latipes) in an early life stage test (Results of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment, 2006)).
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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