NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	7782-63-0
Chemical Name	Iron(II) sulfate heptahydrate
Substance ID	25A0075
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solid	Not classified	- -	-	-	Not combustible (NITE Chemical Risk Information Platform (NITE-CHRIP) (Access on August 2013)).
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	- -	-	-	Not combustible (NITE Chemical Risk Information Platform (NITE-CHRIP) (Access on August 2013)).
11	Self-heating substances and mixtures	Not classified	- -	-	-	Not combustible (NITE Chemical Risk Information Platform (NITE-CHRIP) (Access on August 2013)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	From information on water solubility: 29.5 g/100 g (NITE Chemical Risk Information Platform (NITE-CHRIP) (Access on August 2013)), it is recognized that it does not react vigorously with water.
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound which does not contain halogen but contains oxygen, however, the classification is not possible due to no data.
15	Organic peroxides	Not applicable	- -	-	-	It is an inorganic substance.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	There are reports on LD50 values for rats of 1,389 mg/kg (EPA Pesticide (1993)) and > 2,000 mg/kg (JECDB (Access on October 2013)) (OECD TG 401). Because there are the same numbers for both Category 4 and "Not classified," it was classified in Category 4 according to the GHS classification guidance for the Japanese government.
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, this substance is classified in "Xi; R36/38" in EU DSD classification and "Skin Irrit. 2 H315" in EU CLP classification.
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, this substance is classified in "Xi; R36/38" in EU DSD classification and "Eye Irrit. 2 H319" in EU CLP classification.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. There is the knowledge that it was negative in an in vivo micronucleus test with the stomach, duodenum, and colon (J. Appl. Toxicol. 8, 179-183, 1988), and a category of iron salts was assessed in SIDS, and the category was evaluated to be not mutagenic in vivo. As for in vitro, it was negative in a bacterial reverse mutation test and positive in a chromosomal aberration test with cultured mammalian cells (JECDB (Access on October 2013)).
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG422) with rats in the oral route (gavage), no fertility effects were observed at the dose (1,000 mg/kg/day) where effects were seen in parent animals. And no effects were found in offspring (JECDB (Access on October 2013)). However, because it is a screening test, and there are no sufficient reports on developmental toxicity, it was classified as "Classification not possible."
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, it is reported that after gavage administration to rats, a decrease in locomotor activity, salivation, and a transient decrease in body weights were observed at 2,000 mg/kg, the maximum guidance value, but no other toxic signs were found (JECDB (Access on October 2013)). However, there are no reports on the other routes.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	This substance was recognized as GRAS (Generally Recognized As Safe) substance as food additives by the U.S. FDA (EPA Pesticide (1993)). Furthermore, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats by gavage administration, increased extramedullary hematopoiesis in the spleen (only in males) was observed at the dose (163 mg/kg/day (converted guidance value)) above the guidance value range for Category 2 (JECDB (Access on Sep. 2013)). From the above, it corresponds to "Not classified" in the oral route. However, because of no toxicity information on the other routes, the classification is not possible due to lack of data.
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 3	- -	H402	P273 P501	From 48-hour EC50 = 91 mg/L for crustacea (Daphnia magna) (SIDS, 2008), it was classified in Category 3.
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	If chronic toxicity data are used, then it is classified as "Not classified" due to no appropriate data obtained on rapid degradability, and 21-day NOEC = 10 mg/L for crustacea (Daphnia magna) (SIDS, 2008). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to 96-hour LC50 > 67 mg/L for fish (Oryzias latipes) (SIDS, 2008) although appropriate data on rapid degradability were not obtained. From the above results, it was classified as "Not classified."
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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