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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	112-72-1
Chemical Name	Tetradecan-1-ol
Substance ID	25A0078
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	New
Classification result in other fiscal year
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solid	Classification not possible	- -	-	-	It is combustible, but the classification is not possible due to no data.
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 240 deg C (GESTIS (Access on December 2013)).
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	It is a solid with a melting point of 55 deg C or lower, but the classification is not possible due to no data.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was classified as "Not classified" based on reports on LD50 values for rats of > 5,000 mg/kg (PATTY (6th, 2012)), > 20,000 mg/kg, and 26,975 mg/kg (SIDS (2007)).
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" based on LD50 values for rabbits of > 5,000 mg/kg (PATTY (6th, 2012)), 5,847 mg/kg, and 8,000 mg/kg (SIDS (2007)).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there is a report on an LC50 value (4 hours) of > 0.375 mg/L for rats (SIDS (2007)).
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	It is described in SIDS (2007) that in a test in which a 50% solution of this substance (in a 1% solution of gum tragacanth) was applied to the skin of rabbits for 24 hours, the average erythema scores at 24, 48, 72 hours after application were 2.43 for intact skin and 2.53 for abraded skin, and the average edema scores were 1.83 for intact skin and 3.26 for abraded skin. Other than this, it is reported in SIDS (2007) that this substance was not irritating in a test in which 20 male and female volunteers were given a 4-hour semi-occlusive application of undiluted this substance. However, the animal test results with positive responses were prioritized, and it was classified in Category 2.
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	It is described that in a test on undiluted this substance according to OECD TG 405, it was moderately irritating (score after 24 hours: 27.3), but the symptoms were reversible within seven days (SIDS (2007)), and it was reported to be slightly irritating (PATTY (6th, 2012)). Therefore, it was classified in Category 2B.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Not classified	- -	-	-	It was classified as "Not classified" because it is reported in SIDS (2007) that it was negative in a test with guinea pigs according to OECD TG 406.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There are no in vivo or in vitro test data on this substance. Besides, it is described in ECHA (Access on December 2013) that it was negative in a bacterial reverse mutation test (ECHA (Access on December 2013)). Furthermore, in SIDS (2007), a category of long-chain aliphatic alcohols including this substance was assessed, and it is described that the category was not mutagenic.
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, neither parental toxicity nor reproductive toxicity was observed in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats (IUCLID (2000)). However, because it is a screening test, it was classified as "Classification not possible" due to lack of data.
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, in oral administration test with rats, hypoactivity, diarrhea, hypersalivation, diuresis, ocular porphyrin deposits, and emaciation were observed at the doses (7.26-20 g/kg) above the guidance value range (SIDS (2007)). No effects were seen in rats by inhalation exposure (1 hour, dust) at the dose (1.5 mg/L: converted 4-hour equivalent value: 0.375 mg/L) within the guidance value range (SIDS (2007)). It is reported that after dermal exposure (2-8 g/kg) to rabbits, the animals showed weakness, emaciation, etc., which were reversible (SIDS (2007)).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data.
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Not classified	- -	-	-	From 96-hour ErC50 > 10 mg/L for algae (Desmodesmus subspicatus), and 96-hour LC50 > 1 mg/L for fish (Oncorhynchus mykiss) (both SIDS, 2007), it was classified as "Not classified."
11	Hazardous to the aquatic environment (Long-term)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (a degradation rate: 28% (SIDS, 2007)), and 21-day NOEC = 0.0016 mg/L for crustacea (Daphnia magna) (SIDS, 2007). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, from 96-hour ErC50 > 10 mg/L for algae (Desmodesmus subspicatus), and 96-hour LC50 > 1 mg/L for fish (Oncorhynchus mykiss) (both SIDS, 2007), acute toxicity was not observed around at water solubility, however, it is classified in Category 4 due to being not rapidly degradable (a degradation rate: 28% (SIDS, 2007)), and a high bioaccumulation estimate (log Kow = 6.03 (> 4.0, HSDB, 2013)). By drawing a comparison between the above results, it was classified in Category 1.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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