Item | Information |
---|---|
CAS RN | 7440-50-8 |
Chemical Name | Copper |
Substance ID | 25B0005 |
Classification year (FY) | FY2013 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance by the Japanese Government (July, 2013) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
7 | Flammable solid | Classification not possible |
- |
- | - | There is a possibility of categorization for micronized copper, but there are no data. |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | There is a possibility of categorization for micronized copper, but there are no data. |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | There is a possibility of categorization for micronized copper, but there are no data. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It is estimated that copper does not emit hydrogen in contact with water because it has a lower ionization tendency than hydrogen. |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
14 | Oxidizing solids | Not applicable |
- |
- | - | Inorganic substances containing no oxygen or halogen atoms. |
15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic substance. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, it is described in PATTY (6th, 2012) that contact dermatitis associated with copper has been reported, but few cases of dermatitis caused by copper metal or its compounds occur in the industry. |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Category 1A |
Warning |
H317 |
P302+P352
P333+P313 P362+P364 P261 P272 P280 P321 P501 |
It was classified in Category 1A because the Japan Society for Occupational Health (JSOH) classified copper and its compounds as occupational skin sensitizers Group 2 (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2012)), and it applies to this substance (OEL Documentations (Sensitization classification) (Japan Society For Occupational Health (JSOH, May 26, 2010))). |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
6 | Carcinogenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because the U.S. EPA classified it in I (IRIS (2005)). The category was revised according to the revised GHS classification guidance for the Japanese government. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 1 (digestive system), Category 3 (respiratory tract irritation) |
Danger Warning |
H370
H335 |
P308+P311
P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
From the knowledge in humans in EHC (1998), ACGIH (7th, 2001), and ATSDR (2004), respiratory symptoms (respiratory tract irritation) are the main acute toxic signs in the inhalation route. As for oral exposure, it is described that digestive symptoms (nausea, vomiting, abdominal pain, etc.) were observed after the ingestion of drinking-water and others containing high copper concentrations, and there are numerous reports that nausea and vomiting mainly occurred. Other than these, it is reported in EHC that inhalation exposure caused hepatomegaly, but the air levels were very high, and it is described in ATSDR that liver lesions from acute copper poisoning are rare except for specific diseases (Wilson's disease, etc.). Therefore, the liver was not included in the target organs, and it was classified in Category 1 (digestive system), Category 3 (respiratory tract irritation). |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | It is reported in EHC (1998), DFGOT vol. 22 (2006) that repeated oral exposure to copper in humans caused digestive symptoms (nausea, vomiting, abdominal pain, etc.) and liver disorder (hepatic failure, cirrhosis). Because digestive symptoms are nausea, vomiting, abdominal pain, etc., they cannot be regarded as specific target organ toxicity. Furthermore, hepatic failure is reported in only one case, therefore it was judged impossible to generalize it. From the above, it was classified as "Classification not possible." |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | Due to a lack of data. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | Due to a lack of data. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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