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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	115-07-1
Chemical Name	Propene; Propylene
Substance ID	25B0011
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2008
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	Gas (GHS definition)
2	Flammable gases (including chemically unstable gases)	Category 1	Danger	H220	P210 P377 P381 P403	From explosion limit (2.4-10.3% (ICSC (1998))), it was classified in Category 1. Besides, it is classified in Division 2.1 (UN1077) in UNRTDG.
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not classified	- -	-	-	It is a flammable gas classified in Division 2.1 in UNRTDG.
5	Gases under pressure	Liquefied gas	Warning	H280	P410+P403	From a critical temperature (91.8 deg C (HSDB (Access on July 2013))) above + 65 deg C, it was classified as liquefied gas.
6	Flammable liquids	Not applicable	- -	-	-	Gas (GHS definition)
7	Flammable solid	Not applicable	- -	-	-	Gas (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	Gas (GHS definition)
9	Pyrophoric liquids	Not applicable	- -	-	-	Gas (GHS definition)
10	Pyrophoric solids	Not applicable	- -	-	-	Gas (GHS definition)
11	Self-heating substances and mixtures	Not applicable	- -	-	-	Gas (GHS definition)
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	Gas (GHS definition)
13	Oxidizing liquids	Not applicable	- -	-	-	Gas (GHS definition)
14	Oxidizing solids	Not applicable	- -	-	-	Gas (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Gas (GHS definition)
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to gas substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not applicable	- -	-	-	Gas (GHS definition)
1	Acute toxicity (Dermal)	Not applicable	- -	-	-	Gas (GHS definition)
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	It was classified as "Not classified" based on the information that no toxicity was observed even after 4 hours at 50,000 ppm in an inhalation test with rats (IARC 60 (1994)).
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Gas (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Not applicable	- -	-	-	Gas (GHS definition)
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it is described that it was negative in a micronucleus test with rat bone marrow cells and a gene mutation test (hprt gene mutation) with T-lymphocytes separated from rat spleen (SIDS (2008), ACGIH (7th, 2001)). And as for in vitro, it was positive only in TA1535 in the presence of metabolic activation in bacterial reverse mutation tests, but it is reported that it was negative in a mouse lymphoma test with cultured mammalian cells (SIDS (2008), ACGIH (7th, 2001), IARC (1994)), and it is described that this substance is not an in vivo mutagen based on the available evidence (SIDS (2008)).
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" based on the assessments of Group 3 by IARC and A4 by ACGIH. Besides, increased tumor incidence was not observed in carcinogenicity tests with mice and rats by inhalation exposure (NTP TR272 (1985)). The category was changed according to the revised GHS classification guidance for the Japanese government.
7	Reproductive toxicity	Classification not possible	- -	-	-	It is reported that in an inhalation test with rats exposed during the organogenesis period (OECD TG 412/414), no teratogenicity or fetotoxicity was observed, and no abnormalities were found in parent animals (ACGIH (7th, 2001)). However, because of no information on sexual function and fertility in males and females, the classification is not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	Narcotic effects were observed in reports of an inhalation test with rats (SIDS (2008)), an inhalation test with mice (SIDS (2008), ACGIH (7th, 2001)), an inhalation test with humans (ACGIH (7th, 2001)), and an inhalation test with cats (SIDS (2008), ACGIH (7th, 2001)), and it is described that they recovered in a relatively short time after exposure. Therefore, it was classified in Category 3 (narcotic effects).
9	Specific target organ toxicity - Repeated exposure	Not classified	- -	-	-	In four tests in which rats and mice were exposed by inhalation at 625-10,000 ppm for two weeks (converted guidance value: 96-1,538 ppm) or 14 weeks (NTP TR272 (1985)), there were no effects on general conditions and body weights in any test, and in necropsy and histopathological examinations, no effects of test substance were observed, including those in the nasal cavity. And also in cases of inhalation exposure in rats at 200-10,000 ppm (converted guidance value: 44-2,222 ppm) for 20 days (ACGIH (7th, 2001)), or mice at 200-5,000 ppm for 78 weeks (IARC 60 (1994)), no effects of test substance were shown. Furthermore, in 103-week inhalation exposure tests with rats and mice at 5,000, 10,000 ppm (NTP TR272 (1985)), as non-neoplastic lesions, there were no descriptions of effects of test substance except for changes in the nasal cavity such as squamous metaplasia, epithelial hyperplasia, and inflammation, and changes in the nasal cavity were not reported in 2-14-week exposure tests. From the above, no adverse effects of test substance were observed even at the exposure levels above the guidance values in multiple repeated inhalation exposure tests (8 tests) with rats and mice. Because this substance is gas in GHS definition, the normal exposure route is considered to be the inhalation route. Therefore, it was classified as "Not classified" from data in the inhalation route.
10	Aspiration hazard	Not applicable	- -	-	-	Gas (GHS definition)

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 3	- -	H402	P273 P501	From 96-hour EC50 = 33.39 mg/L by ECOSAR for algae (SIDS, 2008), it was classified in Category 3.
11	Hazardous to the aquatic environment (Long-term)	Category 3	- -	H412	P273 P501	Reliable chronic toxicity data were not obtained. It was classified in Category 3 because it is not rapidly degradable (a degradation rate by BOD: 1% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2002)), and it was classified in Category 3 in acute toxicity.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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