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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	75-71-8
Chemical Name	Dichlorodifluoromethane
Substance ID	25B0020
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	Gas (GHS definition)
2	Flammable gases (including chemically unstable gases)	Not classified	- -	-	-	It is classified in Division 2.2 (UN1028) in UNRTDG (not flammable and not toxic gas).
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not classified	- -	-	-	It is classified in Division 2.2 (UN1028) in UNRTDG and not given a Subsidiary Risk of 5.1 (oxidization).
5	Gases under pressure	Liquefied gas	Warning	H280	P410+P403	From a critical temperature (111.8 deg C (HSDB (Access on July 2013))) above + 65 deg C, it was classified as liquefied gas (low pressure liquefied gas).
6	Flammable liquids	Not applicable	- -	-	-	Gas (GHS definition)
7	Flammable solid	Not applicable	- -	-	-	Gas (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	Gas (GHS definition)
9	Pyrophoric liquids	Not applicable	- -	-	-	Gas (GHS definition)
10	Pyrophoric solids	Not applicable	- -	-	-	Gas (GHS definition)
11	Self-heating substances and mixtures	Not applicable	- -	-	-	Gas (GHS definition)
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	Gas (GHS definition)
13	Oxidizing liquids	Not applicable	- -	-	-	Gas (GHS definition)
14	Oxidizing solids	Not applicable	- -	-	-	Gas (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Gas (GHS definition)
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to gas substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not applicable	- -	-	-	Besides, it is reported that an LD50 value was > 1,000 mg/kg (EHC 113 (1990)), and no death was observed at 1,000 mg/kg (DFGOT vol. 5 (1993)) when the target substance was dissolved in peanut oil and orally administered to rats.
1	Acute toxicity (Dermal)	Not applicable	- -	-	-	Gas (GHS definition)
1	Acute toxicity (Inhalation: Gases)	Not classified	- -	-	-	It was classified as "Not classified" because an LC50 value of 760,000-800,000 mL/m3 for rats by inhalation exposure (converted 4-hour equivalent value: 268,701-282,842 ppm) (DFGOT vol. 5 (1993)) exceeded 12,500 ppm (gas 2,000 ppm (Category 4)).
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Gas (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Not applicable	- -	-	-	Gas (GHS definition)
2	Skin corrosion/irritation	Not classified	- -	-	-	From the information that it is slightly irritating (EHC 113 (1990)) and that there is no irritation (DFGOT vol. 5 (1993)), it is thought to be minimally or slightly irritating. Therefore, it was classified as "Not classified" (Category 3 in UN GHS classification) in JIS classification.
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	There is the information that no significant eye irritation was observed in rabbits (ACGIH (7th, 2001), PATTY (6th, 2012)), while there is the information that it caused conjunctival irritation (DFGOT vol. 5 (1993)). Therefore, it was classified as "Classification not possible." Because the information in List 1 (DFGOT vol. 5 (1993)) was obtained in this investigation, the information in List 3, Chemical Substance Hazard Data (CERI), was deleted, and the classification was revised.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. As for rationale data for respiratory sensitization in the previous classification (DFGOT vol. 5 (1993)), the animal species used was dogs, and the test method was not according to the guidelines, therefore it is was insufficient to classify it as "Not classified" for respiratory sensitization. Because no other usable data were obtained, the classification was revised.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it is reported that it was negative in dominant lethal tests with rats by oral administration or mice by inhalation exposure (EHC 113 (1990), ACGIH (7th, 2001), JECFA (1975), IUCLID (2000)) and negative in a chromosomal aberration test with rats (IUCLID (2000)). Furthermore, as for in vitro, it was negative in a bacterial reverse mutation test and a gene mutation test with cultured mammalian cells (EHC 113 (1990), ACGIH (7th, 2001), DFGOT vol. 5 (1993), IUCLID (2000)).
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it is classified in A4 in ACGIH (7th, 2001), and it is described that no evidence of carcinogenicity was seen in animal tests (EHC 113 (1990), PATTY (6th, 2012)). The category was changed according to the revised GHS classification guidance for the Japanese government.
7	Reproductive toxicity	Not classified	- -	-	-	In a gavage administration three-generation test with rats, no general toxicity effects or toxicity effects on fertility were observed, and in developmental toxicity tests in rats by gavage administration or inhalation exposure and rabbits by inhalation exposure, no developmental toxicity, fetotoxicity, or teratogenicity was found (EHC 113 (1990), PATTY (6th, 2012)). From the above test results, it was classified as "Not classified."
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	It is described that in inhalation exposure experiments in human volunteers, findings such as slurred speech, decreased performance in psychomotor tests, amnesia, central nervous system depression, cardiac arrhythmia, a decrease in pulse, and a reduction in ventilatory lung capacity were observed (PATTY (6th, 2012), DFGOT vol. 5 (1993)), and central nervous system narcosis was found in tests in which rats and guinea pigs were given short-term inhalation exposure at high concentrations (500,000-900,000 ppm, 30 minutes) (EHC 113 (1990)). Therefore, it was classified in Category 3 (narcotic effects).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	As for reports on occupational exposure in humans, concerning death cases by inhalation exposure to a variety of halocarbon including this substance, there is a report that deaths were caused by cardiac arrhythmia while there is another report that there was no increase in deaths by occupational exposure, and there was no arrhythmia (PATTY (6th, 2012)). It is described in EHC 113 (1990) that deaths due to cardiac arrhythmia were observed for occupational exposure to halocarbon (CFC-113: trichlorotrifluoroethane), which is not this substance, but the similar case was not reported for exposure to this substance. Furthermore, nervous symptoms and low nerve conduction velocities were found in a refrigerator repair worker, and in a follow-up study, the symptoms were seen, but low nerve conduction velocities were not observed (EHC 113 (1990)). Therefore, effects on the nervous system are unclear together with the association with exposure to this substance. On the other hand, as for experimental animals, it is described that in a 90-day inhalation exposure test with guinea pigs, histological changes in the liver were found at the concentration (converted guidance value: 1,080 ppm) above the guidance value range for Category 2, but no toxicity effects were seen in other tests with rats or dogs in the inhalation or oral route (PATTY (6th, 2012)). From the above, the classification corresponds to "Not classified" in experimental animals, but it is unclear at this point whether occupational exposure affects the circulatory organ system and nervous system in humans, and there is no conclusive evidence on human health effects. Therefore, it was judged appropriate to classify it as "Classification not possible."
10	Aspiration hazard	Not applicable	- -	-	-	Gas (GHS definition)

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Classification not possible	- -	-	-	No data available.
11	Hazardous to the aquatic environment (Long-term)	Classification not possible	- -	-	-	No data available.
12	Hazardous to the ozone layer	Category 1	Warning	H420	P502	This substance is listed in the Annexes to the Montreal Protocol

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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