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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	108-03-2
Chemical Name	1-Nitropropane
Substance ID	25B0025
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not classified	- -	-	-	There is a chemical group associated with explosive properties (nitro group) in the molecule. However, it is classified in Class 3 (UN2608), not in Class 1 in UNRTDG.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	From a flash point of 36 deg C (closed cup) (HSDB (Access on July 2013)), it was classified in Category 3. Besides, it is classified in Class 3, PG III (UN2608) in UNRTDG.
7	Flammable solid	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Type G	- -	-	-	There is a chemical group associated with explosive properties (nitro group) in the molecule. However, it is classified in Class 3 (UN2608) in UNRTDG, and it does not correspond to hazards of the highest precedence, self-reactive substances and mixtures.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 421 deg C (ICSC (1996)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Classification not possible	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded to the element other than carbon or hydrogen (N). However, the classification is not possible due to no data.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.The classification was revised according to the GHS classification guidance for the Japanese government.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It was classified in Category 4 based on LD50 values for rats of 455 mg/kg (HSDB (Access on July 2013)) and 484-528 mg/kg (IUCLID (2000)).
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" based on an LD50 value of > 2,000 mg/kg for rabbits (IUCLID (2000), HSDB (Access on July 2013)).
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	It was classified in Category 3 based on an LC50 value (1 hour) for rats of 11.02 mg/L (converted 4-hour equivalent value: 5.51 mg/L = 1,512 ppmV) (HSDB (Access on July 2013)). Besides, the test concentration (1,512 ppmV) is lower than 90% of the saturated vapour pressure concentration (13,289 ppmV), it was judged as a vapour with little mist, and a reference value in the unit of ppmV was applied.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	It is described in IUCLID (2000) that no skin irritation was observed in a test with rabbits, but it is described in Sittig (6th, 2012) that it may irritate the skin. Therefore, it was classified as "Classification not possible" due to lack of data.
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	It was classified in Category 2 because it is described in ACGIH (7th, 2001), PATTY (6th, 2012), and DFGOT vol.13 (1999) that eye irritation was observed after exposure to the vapour in humans, and it is described in ICSC (J) (1996) that it irritates the eye.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	It is described in IUCLID (2000) that no skin sensitization was observed in guinea pigs, but no List 1 documents have a description denying sensitization. Therefore, it was classified as "Classification not possible."
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in micronucleus tests with erythrocytes of mice and rats, a micronucleus test with rat hepatocytes, and a DNA repair synthesis test with rat liver (PATTY (6th, 2012)). Furthermore, as for in vitro, it was negative in a bacterial reverse mutation test (ACGIH (7th, 2001), PATTY (6th, 2012), NTP DB (Access on June 2013), IUCLID (2000)) and chromosomal aberration tests with human lymphocytes (PATTY (6th, 2012)) and cultured Chinese hamster cells (IUCLID (2000)).
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because ACGIH classified it in A4 (ACGIH (7th, 2001)). The category was changed according to the revised GHS classification guidance for the Japanese government.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 1 (digestive system), Category 3 (respiratory tract irritation, narcotic effects)	Danger Warning	H370 H335 H336	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	It was classified in Category 1 (digestive system) because it is described that digestive symptoms (anorexia, nausea, vomiting, intermittent diarrhea) were observed after inhalation exposure in humans (PATTY (6th, 2012)). On the other hand, as for experimental animals, in an inhalation exposure test with rabbits, systemic symptoms such as ataxia and weakness in addition to irritation of the eye and respiratory system are reported (ACGIH (7th, 2001)), therefore it was classified in Category 3 (respiratory tract irritation, narcotic effects).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In a 21.5-month inhalation exposure test with rats, toxicity supporting categorization was not observed at the concentration (converted guidance value: 0.32 mg/L/6 hours) above the guidance value range for Category 2 (ACGIH (7th, 2001), PATTY (6th, 2012)), and it corresponds to "Not classified" in the inhalation route. And in a 28-day oral administration test with rats, lower values of body weights and increased kidney weights were found at the maximum dose tested (33.3 mg/kg/day (converted guidance value)), but effects are unknown at the upper limit of the guidance value range for Category 2, and the data are qualitatively insufficient to classify it for the target organs. Therefore, data are lacking in the routes other than the inhalation route, and it was classified as "Classification not possible."
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Not classified	- -	-	-	From 72-hour ErC50 > 456 mg/L for algae, 48-hour EC50 = 380 mg/L for crustacea, and 96-hour LC50 = 227 mg/L for fish (SIAP Conclusions Agreed in SIAM 31, 2010), all of them is > 100 mg/L, therefore it was classified as "Not classified."
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. It was classified as "Not classified" because it is not water-insoluble (water solubility = 1.5x 10^4 mg/L, HSDB, 2013), and it was classified as "Not classified" in acute toxicity.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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