Item | Information |
---|---|
CAS RN | 111-40-0 |
Chemical Name | N-(2-Aminoethyl)-1,2-ethanediamine; Diethylenetriamine |
Substance ID | 25B0028 |
Classification year (FY) | FY2013 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance by the Japanese Government (July, 2013) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Not classified |
- |
- | - | A flash point is 97 deg C (closed cup) (ICSC (1996)) above 93 deg C. |
7 | Flammable solid | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 358 deg C (ICSC (1996)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 |
P301+P312
P264 P270 P330 P501 |
It was classified in Category 4 based on LD50 values of 1,080 mg/kg (ACGIH (7th, 2001), Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), PATTY (6th, 2012)), about 1,140 mg/kg, 1,539 mg/kg, about 1,800 mg/kg, and 1,950 mg/kg (SIDS (2002)) in oral administration tests with rats. |
1 | Acute toxicity (Dermal) | Category 4 |
Warning |
H312 |
P302+P352
P362+P364 P280 P312 P321 P501 |
LD50 values in dermal administration tests with rabbits are about 672 mg/kg, 1,040 mg/kg (SIDS (2002)), and 1,090 mg/kg (ACGIH (7th, 2001), Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013)), one corresponds to Category 3, and two correspond to Category 4. According to the revised GHS classification guidance for the Japanese government, it was classified in Category 4 to which most data corresponded. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, the result in the Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), the rationale for the previous classification, was not adopted because it was LDLo. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 |
P301+P330+P331
P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
Strong corrosivity or corrosivity is described as health effects in humans (Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)) and the results of skin irritation tests with rabbits (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), SIDS (2002)). Furthermore, this substance is classified in "C; R34" in EU DSD classification and "Skin Corr. 1B H314" in EU CLP classification. It was classified in Category 1 based on the above information. |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
Strong irritation, high corrosivity, or loss of vision is described as data on health effects in humans (Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), ACGIH (7th, 2001)) and the results of administering the undiluted substance in eye irritation tests with rabbits (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), SIDS (2002)). Furthermore, this substance is a skin irritant and is classified in "C; R34" EU DSD classification and "Skin Corr. 1B H314" in EU CLP classification. It was classified in Category 1 based on the above information. |
4 | Respiratory sensitization | Category 1 |
Danger |
H334 |
P304+P340
P342+P311 P261 P284 P501 |
As data on health effects in humans, it is described that asthma-like allergic reactions in the respiratory tract from occupational exposure are reported (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), SIDS (2002), ACGIH (7th, 2001)), therefore it was considered to cause respiratory sensitization, and it was classified in Category 1. |
4 | Skin sensitization | Category 1 |
Warning |
H317 |
P302+P352
P333+P313 P362+P364 P261 P272 P280 P321 P501 |
It was considered to be sensitizing to the skin because of a positive result in a maximization test with guinea pigs (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), SIDS (2002)), reports that positive results were observed in patch tests in workers handling this substance, etc. (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), SIDS (2002), ACGIH (7th, 2001)). Furthermore, this substance is classified in "R43" in EU DSD classification and "Skin Sens. 1 H317" in EU CLP classification. It was classified in Category 1 based on the above information. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a micronucleus test with mouse bone marrow cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), SIDS (2002)). Furthermore, as for in vitro, it was negative in a bacterial reverse mutation test and a gene mutation test and a chromosomal aberration test with cultured mammalian cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), SIDS (2002)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was not classified by other organizations, and there is toxicity information but no reliable information. |
7 | Reproductive toxicity | Category 1B |
Danger |
H360 |
P308+P313
P201 P202 P280 P405 P501 |
It is described in the Initial Risk Assessment Report (NITE, CERI, NEDO, 2005) and Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013) that in a reproduction/developmental toxicity screening test with rats (OECD TG 421), reproductive and developmental effects (extension of a gestation period, increased embryonic/fetal death, etc.) were observed at the dose where no other toxicity signs were seen in parent animals. Therefore, it was classified in Category 1B according to the GHS classification guidance for the Japanese government. |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 3 |
- |
H402 |
P273
P501 |
From 48-hour EC50 = 16 mg/L for crustacea (Daphnia magna) (SIDS, 2002), it was classified in Category 3. |
11 | Hazardous to the aquatic environment (Long-term) | Not classified |
- |
- | - |
If chronic toxicity data are used, then it is classified as "Not classified" due to being not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1982)), and 21-day NOEC = 5.6 mg/L for crustacea (Daphnia magna) (SIDS, 2002). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to being not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1982)), and 96-hour LC50 = 248 mg/L for fish (Leuciscus idus) (SIDS, 2002). From the above results, it was classified as "Not classified." |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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