Item | Information |
---|---|
CAS RN | 116-14-3 |
Chemical Name | Tetrafluoroethylene |
Substance ID | 25B0029 |
Classification year (FY) | FY2013 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance by the Japanese Government (July, 2013) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | Gas (GHS definition) |
2 | Flammable gases (including chemically unstable gases) | Category 1, Category B |
Danger |
H220
H231 |
P210
P377 P381 P403 P202 |
From explosion limit (10.0-50.0% (NFPA (13th,2002))), it was classified in Category 1. Besides, it is classified in Division 2.1 (UN1081) in UNRTDG. It was classified in Category B from the judgment result in UNRTDG Test Manual (2011). |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not classified |
- |
- | - | It is a flammable gas classified in Division 2.1 (UN1081) in UNRTDG. |
5 | Gases under pressure | Liquefied gas |
Warning |
H280 | P410+P403 | From a critical temperature (33.3 deg C (HSDB (Access on July 2013))) between -50 deg C and +65 deg C, it was classified as liquefied gas. |
6 | Flammable liquids | Not applicable |
- |
- | - | Gas (GHS definition) |
7 | Flammable solid | Not applicable |
- |
- | - | Gas (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | Gas (GHS definition) |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Gas (GHS definition) |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Gas (GHS definition) |
11 | Self-heating substances and mixtures | Not applicable |
- |
- | - | Gas (GHS definition) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | Gas (GHS definition) |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Gas (GHS definition) |
14 | Oxidizing solids | Not applicable |
- |
- | - | Gas (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Gas (GHS definition) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to gas substances are not available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not applicable |
- |
- | - | Gas (GHS definition) |
1 | Acute toxicity (Dermal) | Not applicable |
- |
- | - | Gas (GHS definition) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | It was classified as "Not classified" based on LC50 (4 hours) of 25,000 ppm (ACGIH (7th, 2001)), 31,000 ppm (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)), 40,000 ppm (ECETOC JACC (2003)), and 45,000 ppm (ACGIH (7th, 2001)) in inhalation exposure tests (gas) with rats. |
1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Gas (GHS definition) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not applicable |
- |
- | - | Gas (GHS definition) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 |
P305+P351+P338
P337+P313 P264 |
It was classified in Category 2B from the description of exposure in humans in HSDB (Access on July 2013) that contact with eyes causes slight irritation. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a micronucleus test with mouse peripheral blood erythrocytes (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007), ACGIH (7th, 2001), IARC 71 (1999), NTP DB (Access on July 2013)). Furthermore, as for in vitro, it was negative in a bacterial reverse mutation test and a gene mutation test and a chromosomal aberration test with cultured mammalian cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007), ACGIH (7th, 2001), IARC 71 (1999), IUCLID (2000)). |
6 | Carcinogenicity | Category 2 |
Warning |
H351 |
P308+P313
P201 P202 P280 P405 P501 |
It was classified in Category 2 because it is classified in 2B in IARC 71 (1999), R in NTP (2011), and 2B in the Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2012). |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 2 (kidney, liver) |
Warning |
H371 |
P308+P311
P260 P264 P270 P405 P501 |
As for experimental animals, it is described that increases in blood urea nitrogen, urine volume, urinary excretion of glucose, and alkaline phosphatase and gamma-glutamyl transpeptidase activities were observed after inhalation exposure to 4,000 and 6,000 ppm in rats (ACGIH (7th, 2001), Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)), therefore the kidney and liver were judged to be the target organs. Besides, these effects in experimental animals were found within the guidance value range corresponding to Category 2. From the above, it was classified in Category 2 (kidney, liver). |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (kidney, liver) |
Warning |
H373 |
P260
P314 P501 |
As for experimental animals, it is described that in a 2-year inhalation exposure test with rats, males showed renal tubular degeneration and cystic degeneration in the liver after exposure to 156 ppm (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007), ACGIH (7th, 2001)), therefore the kidney and liver were considered to be the target organs. Besides, these effects in experimental animals were observed within the guidance value range corresponding to Category 2. From the above, it was classified in Category 2 (kidney, liver). |
10 | Aspiration hazard | Not applicable |
- |
- | - | Gas (GHS definition) |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Classification not possible |
- |
- | - | No data available. |
11 | Hazardous to the aquatic environment (Long-term) | Classification not possible |
- |
- | - | No data available. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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