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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	118-74-1
Chemical Name	Hexachlorobenzene
Substance ID	25B0030
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solid	Classification not possible	- -	-	-	No data available.
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available. The classification was revised according to the GHS classification guidance for the Japanese government.
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available. The classification was revised according to the GHS classification guidance for the Japanese government.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	- -	-	-	The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was classified as "Not classified" based on LD50 values for rats: 3,500 mg/kg (EHC 195 (1997), ACGIH (7th, 2001), DFGOT vol. 16 (2001), PATTY (6th, 2012), IARC 79 (2001), ATSDR (2002)) and 10,000 mg/kg (Environmental Risk Assessment for Chemical Substances vol. 1 (Ministry of the Environment, 2002), EHC 195 (1997), ACGIH (7th, 2001), IARC 79 (2001)). Besides, the classification was changed from Category 5 to "Not classified" according to the GHS classification guidance for the Japanese government.
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Category 4	Warning	H332	P304+P340 P261 P271 P312	It was classified in Category 4 based on a report on an inhalation LC50 value of 4,000 mg/m3 (4 mg/L) for mice (CEPA (1993)). Besides, because the test concentration was higher than the saturated vapour pressure concentration of 7.42*10-4 mg/L, a reference value in the unit of mg/L was applied as dust/mist.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, it is described that it has a low skin irritation score in a test with guinea pigs (EHC 195 (1997)), it has little irritating effect on the skin in a test with unknown animal species (DFGOT vol. 16 (2001)), or it is not irritating to the skin or eye (Environmental Risk Assessment for Chemical Substances vol. 1 (Ministry of the Environment, 2002)), but the details such as application time are unknown.
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, it is described that it is not irritating to the eye in a test with guinea pigs (EHC 195 (1997)), it has no effects on the eye in a test with unknown animal species (DFGOT vol. 16 (2001)), or it is not irritating to the skin or eye (Environmental Risk Assessment for Chemical Substances vol. 1 (Ministry of the Environment, 2002) (2002)), but the details such as application time are unknown.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, a negative result in a dominant lethal test with rats is reported (ATSDR (2002), EHC 195 (1997), ACGIH (7th, 2001), DFGOT vol. 16 (2001), PATTY (6th, 2012), IARC 79 (2001), IUCLID (2000)). And it was negative in a DNA single-strand-break test with rat hepatocytes (IARC 79 (2001)), a sister chromatid exchange test with mouse bone marrow cells (IARC 79 (2001), DFGOT vol.16 (2001)), and a DNA single-strand-break test with mice (details: not described) (DFGOT vol. 16 (2001)). Furthermore, as for in vitro, it was negative in a bacterial reverse mutation test (EHC 195 (1997), IARC 79 (2001), ATSDR (2002), NTP DB (Access on July 2013), DFGOT vol. 16 (2001)) and a chromosomal aberration test with cultured mammalian cells (EHC 195 (1997), IARC 79 (2001), ATSDR (2002), DFGOT vol. 16 (2001)).
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	It was classified in Category 2 because it is classified in Group 2B by IARC (IARC 79 (2001)), A3 by ACGIH (ACGIH (1996)), and R by NTP (NTP (1983)), although it is classified in "Carc. Cat. 2; R45" in EU DSD classification, "Carc. 1B H350" in EU CLP classification, and B2 by EPA (IRIS (1991)).
7	Reproductive toxicity	Category 1B, Additional category: Effects on or via lactation	Danger	H360 H362	P308+P313 P201 P202 P280 P405 P501	It was classified in Category 1B because it is described in the Environmental Risk Assessment for Chemical Substances vol. 1 (Ministry of the Environment, 2002), ACGIH (7th, 2001), EHC 195 (1997), ATSDR (2002), DFGOT vol. 16 (2001), PATTY (6th, 2012), IARC 79 (2001) that increased mortality of offspring after birth was observed from the doses where no toxicity occurred in parent animals in an oral dose breeding test with rats or a test with rats orally dosed during gestation. Furthermore, it is described in IARC 79 (2001), EHC 195 (1997), ATSDR (2002), DFGOT vol. 16 (2001) that in epidemiological cases in Turkey, a high rate of lethality was found in newborns fed breast milk from mothers exposed to this substance, and it was judged to have lactation effects according to the GHS classification guidance for the Japanese government. From the above, it was classified in Category 1B, Additional category: Effects on or via lactation.
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data.
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver, skin, bone, thyroid, nervous system, kidney, endocrine system), Category 2 (immune system)	Danger Warning	H372 H373	P260 P264 P270 P314 P501	It is described in the Environmental Risk Assessment for Chemical Substances vol. 1 (Ministry of the Environment, 2002), ACGIH (7th, 2001), EHC 195 (1997), ATSDR (2002), DFGOT vol. 16 (2001), PATTY (6th, 2012), IARC 79 (2001) that in accidental exposure cases by ingestion in humans, effects on the liver, skin, bone, thyroid, or nervous system were observed, including hepatic disorder, cutaneous porphyria, arthritis, enlargement of the thyroid, and neurological symptoms (neuritis, myotonia). And it is described in IRIS (1991), ATSDR (2002), DFGOT vol.16 (2001), EHC 195 (1997) that in 3-month or 2-year oral dose (feeding) tests with rats, effects on the kidney (increased porphyrin in the kidney, renal cell adenoma, etc.) and adrenal gland (pheochromocytoma) were found at the doses (1.5-5 mg/kg/day) within the guidance value range for Category 1, and it is described in ACGIH (7th, 2001), EHC 195 (1997), ATSDR (2002), IARC 79 (2001), DFGOT vol.16 (2001) that in 3-13-week oral dose (feeding) tests with rats, mice, etc., immunosuppression was seen at the doses (15-40 mg/kg/day) within the guidance value range for Category 2. Therefore, it was classified in Category 1 (liver, skin, bone, thyroid, nervous system, kidney, endocrine system), Category 2 (immune system).
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 1	Warning	H400	P273 P391 P501	From 72-hour EC50 = 0.03 mg/L for algae (Pseudokirchneriella subcapitata) (ECETOC TR91, 2003), it was classified in Category 1.
11	Hazardous to the aquatic environment (Long-term)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1975)), and NOEC = 0.0023 mg/L for crustacea (Penaeus duorarum) (CEPA, 1993). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to being not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1975)), and 72-hour EC50 = 0.03 mg/L for algae (Pseudokirchneriella subcapitata) (ECETOC TR91, 2003). From the above results, it was classified in Category 1.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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