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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	118-96-7
Chemical Name	Trinitrotoluene
Substance ID	25B0031
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Division 1.1	Danger	H201	P370+P380 P210 P230 P240 P250 P280 P372 P373 P401 P501	It is classified in Division 1.1D (UN0209) in UNRTDG.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solid	Classification not possible	- -	-	-	It is classified as explosives, but the classification was not possible due to no data on combustibility.
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	It is classified in Division 1.1D (UN0209) in UNRTDG.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Classification not possible	- -	-	-	It is classified as explosives, but the classification was not possible due to no data on pyrophoricity.
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	It is classified as explosives, but the classification was not possible due to no data on self-heating.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Not classified	- -	-	-	It is classified in Division 1.1D (UN0209) in UNRTDG.
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It was classified in Category 4 based on LD50 values for rats of 795 mg/kg (females) (ATSDR (1995), ACGIH (7th, 2001), IARC 65 (1996), DFGOT vol. 1 (1991)), 820 mg/kg (ATSDR (1995), DFGOT vol. 1 (1991)), 1,010 mg/kg (males) (ATSDR (1995)), 1,320 mg/kg (males) (ATSDR (1995), ACGIH (7th, 2001), IARC 65 (1996), DFGOT vol. 1 (1991)), 1,663.8 mg/kg (females) (DFGOT vol. 1 (1991)), and 1,837.8 mg/kg (males) (DFGOT vol. 1 (1991)).
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	It was classified in Category 2 because it is described in ACGIH (7th, 2001), DFGOT vol. 1 (1991), IARC 65 (1996) that dermatitis was observed in exposure cases in humans, and it is described in the OEL Documentations (Japan Society For Occupational Health (JSOH), 1993) that it is irritating to the skin.
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	It was classified in Category 2 because it is described in PATTY (6th, 2012) and IARC 65 (1996) that it is irritating to human eyes.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	It was classified in Category 1 because it is described in IARC 65 (1996) that allergic contact dermatitis is reported in humans.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. As for in vivo, it was reported to be negative in a micronucleus test with mouse bone marrow cells and a chromosomal aberration test with rat bone marrow cells (IRIS (2012), IARC 65 (1996)) and an unscheduled DNA synthesis test with rat hepatocytes (IARC 65 (1996), IRIS (2012), ATSDR (1995)). On the other hand, as for in vitro, it was positive in a bacterial reverse mutation test (IARC 65 (1996), DFGOT vol. 1 (1991), IRIS (2012), ACGIH (7th, 2001)) and a mouse lymphoma test with cultured mammalian cells (IARC 65 (1996), ACGIH (7th, 2001)). The category was changed according to the revised GHS classification guidance for the Japanese government.
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it is classified in Group 3 in IARC 65 (1996) and C in IRIS (1996). The category was changed according to the revised GHS classification guidance for the Japanese government.
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	There is a description of the effects on sperm from occupational exposure in male workers in PATTY (6th, 2012), and the results of a case-control study showing decreases in semen volumes and the number of motile spermatozoa and increased sperm malformations are described in ATSDR (1995), but it is mentioned that there is insufficient evidence to attribute this to the effects of exposure. On the other hand, it is described in ACGIH (7th, 2001), DFGOT vol. 1 (1991), IARC 65 (1996) that testicular atrophy was observed at the doses where other toxicity effects were seen after repeated exposure to rats, therefore it was classified in Category 2.
8	Specific target organ toxicity - Single exposure	Category 1 (haemal system, liver), Category 3 (respiratory tract irritation)	Danger Warning	H370 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	As the effects of inhalation exposure in humans, there are descriptions of anemic effects from hemolysis and increased activities of blood enzymes (SGOT, LDH) indicating liver disorder in DFGOT vol. 1 (1991) and ACGIH (7th, 2001), and methemoglobinemia, acute liver disorder (yellowing, atrophy), and hepatitis in ACGIH (7th, 2001) and PATTY (6th, 2012). Therefore, the target organs were thought to be the blood system and liver, and it was classified in Category 1. Furthermore, because it is described in ACGIH (7th, 2001) and PATTY (6th, 2012) that it may irritate the nose and throat in humans, and it is described in IARC 65 (1996) that there was a higher prevalence of respiratory symptoms in occupational exposure cases in humans, it was thought to be irritating to the respiratory tract, and it was classified in Category 3.
9	Specific target organ toxicity - Repeated exposure	Category 1 (haemal system, liver, eye, heart, peripheral nervous system)	Danger	H372	P260 P264 P270 P314 P501	As the effects of repeated inhalation exposure in humans, it is described in ACGIH (7th, 2001), DFGOT vol. 1 (1991), IARC 65 (1996), PATTY (6th, 2012) that anemia, liver disorder, and cataract were observed, and it is described in DFGOT vol. 1 (1991) and ACGIH (7th, 2001) that myocardial dystrophy or heart abnormalities and peripheral neuritis were found in occupational exposure cases. Therefore, the target organs were thought to be the blood system, liver, eye, heart, and peripheral nervous system, and it was classified in Category 1.
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 96-hour LC50 = 0.26 mg/L for crustacea (Mysidopsis bahia) (AQUIRE, 2013).
11	Hazardous to the aquatic environment (Long-term)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 2 due to being not rapidly degradable (BIOWIN), and 21-day NOEC = 0.48 mg/L for crustacea (Daphnia magna) (AQUIRE, 2013). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to being not rapidly degradable (BIOWIN), and 96-hour IC50 = 0.72 mg/L for algae (Pseudokirchneriella subcapitata) (AQUIRE, 2013). By drawing a comparison between the above results, it was classified in Category 1.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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