NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	639-58-7
Chemical Name	Triphenyltin chloride
Substance ID	25B0040
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solid	Classification not possible	- -	-	-	No data available.
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of > 250 deg C (NITE Chemical Risk Information Platform (NITE-CHRIP) (Access on September 2013)).
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	From information on water solubility: 40 ppm (20 deg C) (HSDB (Access on September 2013)), it is recognized that it does not react vigorously with water.
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	- -	-	-	It is an organic compound which does not contain fluorine or oxygen but contains chlorine, and because the chlorine is ionically bonded, it does not contribute to oxidization.
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	It was classified in Category 3 based on oral LD50 values for rats of 80 mg/kg (males) (EHC 15 (1980), HSDB (Access on September 2013)), 135 mg/kg (females) (EHC 15 (1980), HSDB (Access on September 2013)), and 190 mg/kg (HSDB (Access on September 2013)).
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	This substance was classified in Category 2 because burns of the skin were observed in humans (HSDB (Access on September 2013)), and strong reactions in the skin were found in rats (RTECS (2004), the original article: NITS OTS0571949, HSDB (Access on September 2013)).
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	This substance was classified in Category 2 because strong reactions were observed in an eye irritation test with rats (a Draize test) (RTECS (2004), the original article: NITS OTS0571949).
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a micronucleus test with mice (CICAD 13 (1999)) and negative in a chromosomal aberration test with Chinese hamsters (CICAD 13 (1999)). Furthermore, as the assessment result of triphenyltin compounds, it is concluded in CICAD 13 (1999) that triphenyltin does not present a genotoxic hazard.
6	Carcinogenicity	Classification not possible	- -	-	-	There are no carcinogenicity data on this substance, but it is concluded that triphenyltin compounds including this substance were assessed to be not carcinogenic (CICAD 13 (1999), EHC 15 (1980)), and it is described in ACGIH that organic tin compounds are classified in A4 (Not Classifiable as a human carcinogen) (ACGIH (1995)). Therefore, it was classified as "Classification not possible." The category was changed according to the GHS classification guidance for the Japanese government.
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	It was classified in Category 2 because implantation inhibition was observed in rats (CICAD 13 (1999)), and reproductive and developmental effects were found for triphenyltin compounds at the doses that caused maternal toxicity in experimental animals (CICAD 13 (1999)).
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, for triphenyltin hydroxide (CAS: 76-87-9), central nervous system symptoms such as emesis, tremor, and drowsiness were observed within the guidance value range for Category 1 after single oral administration to animals (CICAD 13 (1999)).
9	Specific target organ toxicity - Repeated exposure	Category 1 (immune system)	Danger	H372	P260 P264 P270 P314 P501	It was classified in Category 1 (immune system) because, in 2-week or 4-week oral dose (feeding) tests with rats and mice, effects on the immune system such as atrophy of the thymus or spleen were observed at the doses (converted guidance value: 0.23-1.7 mg/kg/day) within the guidance value range for Category 1 (CICAD 13 (1999)), and it is described that triphenyltin compounds may affect the immune system, resulting in impaired function (CICAD 13 (1999)).
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 24-hour LC50 = 0.035 mg/L for crustacea (Daphnia magna) (ECETOC TR91, 2003).
11	Hazardous to the aquatic environment (Long-term)	Category 1	Warning	H410	P273 P391 P501	Reliable chronic toxicity data were not obtained. It was classified in Category 1 because it is not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1988)), and it was classified in Category 1 in acute toxicity.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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