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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	10025-73-7
Chemical Name	Chromium(III) chloride
Substance ID	25B0046
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive properties.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solid	Not classified	- -	-	-	Not combustible (ICSC (2004)).
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	- -	-	-	Not combustible (ICSC (2004)).
11	Self-heating substances and mixtures	Not classified	- -	-	-	Not combustible (ICSC (2004)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	From information on water solubility: slightly soluble in hot water (HSDB (Access on September 2013)), it is recognized that it does not react vigorously with water.
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound containing chlorine (but not oxygen), but the classification is not possible due to no data.
15	Organic peroxides	Not applicable	- -	-	-	It is an inorganic compound.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, no tests in which this substance was specified were conducted, and there are negative results in many of the epidemiological surveys or tests on exposure to trivalent chromium (EHC 61 (1988), ATSDR (2012), PATTY (6th, 2012)).
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	The Japan Society for Occupational Health (JSOH) classified chromium as occupational sensitizers to the airway Group 2 (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2013)). This substance was not specified in this classification, but it was thought that chromium compounds were included. Therefore, this substance, a chromium compound, was also thought to cause respiratory sensitization, and it was classified in Category 1.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	The Japan Society for Occupational Health (JSOH) classified chromium as occupational skin sensitizers Group 1 (Recommendation of Occupational Exposure Limits (Japan Society For Occupational Health (JSOH), 2013)). This substance was not specified in this classification, but it was thought that chromium compounds were included. Therefore, this substance, a chromium compound, was also thought to cause skin sensitization, and it was classified in Category 1.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a micronucleus test with mouse bone marrow cells (ATSDR (2012), CICAD 76 (2009)) and negative in a DNA damage test (alkaline elution method) with rat kidney (CICAD 76 (2009)). As for in vitro, many bacterial reverse mutation tests were negative, and negative and positive results were mixed in chromosomal aberration tests with cultured mammalian cells and human lymphocytes (CICAD 76 (2009), IARC (1999), ATSDR (2012)). And it was negative in a gene mutation test with cultured cells (CICAD 76 (2009), ATSDR (2012)) and positive in a micronucleus test with cultured human cells (CICAD 76 (2009)).
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it is classified in A4 (as chromium metal and Cr (III) compound) in ACGIH (1994), D (as chromium (III), insoluble salts) in EPA (1998), and Group 3 (as chromium (III)) in IARC (1990). The category was changed according to the GHS classification guidance for the Japanese government.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, in a test in which male rats were orally dosed (drinking water) and effects on male fertility and copulation behavior were investigated, decreases in body weight, absolute testis weight, the absolute and relative weight of the seminal vesicle, and the absolute and relative weight of the preputial gland were observed in males, and as for copulation behavior, an increase in the post-ejaculation latency, a decrease in the number of males ejaculating, and decreased aggressivity were found (CICAD 76 (2009), ATSDR (2012)). However, it is reported that no effects on the number of pregnant females, the number of implantations, and the number of viable fetuses were seen. There is no information on developmental toxicity. Therefore, it was classified as "Classification not possible" due to lack of data.
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data.
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 3	- -	H402	P273 P501	It was classified in Category 3 from 24-hour EC50 = 22 mg-Cr/L (equivalent to 67 mg-CrCl3/L) for crustacea (Daphnia magna) (CICADs 76, 2009).
11	Hazardous to the aquatic environment (Long-term)	Category 3	- -	H412	P273 P501	If chronic toxicity data are used, then it is classified as "Not classified" due to 21-day NOEC = 0.7 mg-Cr/L (equivalent to 2.1 mg-CrCl3/L) for crustacea (Daphnia magna) (CICADs 76, 2009; Environmental Risk Assessment for Chemical Substances Vol. 8 (Ministry of the Environment, 2010)), despite unknown behavior of the metal compound, this substance in water. If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 due to 96-hour LC50 = 31.5 mg/L (equivalent to 96 mg-CrCl3/L) for fish (Fundulus heteroclitus) (CICADs 76, 2009), despite unknown behavior of the metal compound, this substance in water. By drawing a comparison between the above results, it was classified in Category 3.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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