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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	127-19-5
Chemical Name	N,N-Dimethylacetamide
Substance ID	25B0050
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2008 FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	-	- -	-	-	-
2	Flammable gases (including chemically unstable gases)	-	- -	-	-	-
3	Aerosols	-	- -	-	-	-
4	Oxidizing gases	-	- -	-	-	-
5	Gases under pressure	-	- -	-	-	-
6	Flammable liquids	-	- -	-	-	-
7	Flammable solid	-	- -	-	-	-
8	Self-reactive substances and mixtures	-	- -	-	-	-
9	Pyrophoric liquids	-	- -	-	-	-
10	Pyrophoric solids	-	- -	-	-	-
11	Self-heating substances and mixtures	-	- -	-	-	-
12	Substances and mixtures which, in contact with water, emit flammable gases	-	- -	-	-	-
13	Oxidizing liquids	-	- -	-	-	-
14	Oxidizing solids	-	- -	-	-	-
15	Organic peroxides	-	- -	-	-	-
16	Corrosive to metals	-	- -	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	-	- -	-	-	-
1	Acute toxicity (Dermal)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Gases)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Vapours)	-	- -	-	-	-
1	Acute toxicity (Inhalation: Dusts and mists)	-	- -	-	-	-
2	Skin corrosion/irritation	-	- -	-	-	-
3	Serious eye damage/eye irritation	-	- -	-	-	-
4	Respiratory sensitization	-	- -	-	-	-
4	Skin sensitization	-	- -	-	-	-
5	Germ cell mutagenicity	-	- -	-	-	-
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	For this substance, a 2-year inhalation carcinogenicity test with males and females of rats and mice was recently conducted in Japan, and there is a report on increased incidences of hepatocellular adenoma and liver tumors: hepatocellular adenoma and carcinoma (combined) in male rats, an increased incidence of hepatocellular adenoma in male mice, and increased incidences of hepatocellular carcinoma and hepatocellular adenoma in female mice (Japan Bioassay Research Center (2013)). It is concluded that there is clear evidence for the carcinogenicity of this substance in the animals mentioned above, and the substance should be the target for the guidelines to prevent the impairment of workers' health (carcinogenicity guidelines) (the meeting document for the committee on the measures to prevent the impairment of workers' health, Ministry of Health, Labour and Welfare (2013)). However, it is reported in SIDS that it was negative in all of a 52-week gavage administration test with rats, a 24-month oral dose (drinking water) test with rats, a 2-year inhalation exposure test with rats, an 18-month inhalation exposure test with mice, and a 6-week dermal administration test with hamsters, and it was assessed to be not carcinogenic (SIDS (2004)). Differences between a report on inhalation exposure in SIDS (2004) and test data in Japan were the animal strains used and the number of exposure days as well as some of the exposure doses. It is unknown whether the differences in the test conditions caused different results, but both contradicting results were judged to be reliable. And there was no available knowledge in humans. Therefore, it was classified in Category 2 because the positive results in Japan were considered not to constitute sufficient evidence to classify the substance in Category 1B. Besides, it was classified as "Not classified" in the previous classification. And it was classified in A4 in ACGIH (7th, 2001).
7	Reproductive toxicity	-	- -	-	-	-
8	Specific target organ toxicity - Single exposure	-	- -	-	-	-
9	Specific target organ toxicity - Repeated exposure	-	- -	-	-	-
10	Aspiration hazard	-	- -	-	-	-

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Not classified	- -	-	-	It was classified as "Not classified" due to 72-hour EC50 > 500 mg/L for algae (Desmodesmus subspicatus), 96-hour LC50 = 966 mg/L for crustacea (Mysidopsis bahia), and 96-hour LC50 = 13300 mg/L for fish (Gambusia affinis) (all SIDS, 2004).
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. It was classified as "Not classified" because it is not water-insoluble (Water solubility: miscible in all proportions, SIDS, 2004), and it was classified as "Not classified" in acute toxicity.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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