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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	135-88-6
Chemical Name	2-(N-Phenylamino)naphthalene
Substance ID	25B0051
Classification year (FY)	FY2013
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2011
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance by the Japanese Government (July, 2013)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solid	Classification not possible	- -	-	-	No data available. Besides, it is described in ICSC (2003) that finely dispersed particles form explosive mixtures in air.
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 deg C) substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine.
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was classified as "Not classified" based on a report on an LD50 value of 8,730 mg/kg for rats (IARC 16 (1978), NTP TR333 (1988), ACGIH (7th, 2001)).
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, this substance was classified in "Xi; R36/R38" in EU DSD classification and "Skin Irrit. 2 H319" in EU CLP classification.
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, this substance was classified in "Xi; R36/R38" in EU DSD classification and "Eye Irrit. 2 H315" in EU CLP classification.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	This substance was listed as a sensitizer in the Frosch contact allergen list (Frosch et al. Contact Dermatitis 5th Ed. (2011)). And it is reported in HSDB (Access on December 2013) that occupational allergic disease was observed in rubber workers due to additives such as this substance. Furthermore, this substance was classified in "R43" in EU DSD classification and "Skin Sens. 1 H317" in EU CLP classification. It was classified in Category 1 based on the above information.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. As for in vivo, it was negative in a chromosomal aberration test with rat bone marrow cells (ACGIH (7th, 2001)), and as for in vitro, it was negative in a bacterial reverse mutation test and a chromosomal aberration test with cultured mammalian cells (ACGIH (7th, 2001), NTP TR333 (1988), NTP DB (Access on September 2013)) and positive in a mouse lymphoma test (NTP DB (Access on September 2013)).
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was classified Group 3 by IARC (IARC suppl. 7 (1987)) and A4 by ACGIH (ACGIH (1995)). Besides, in 2-year diet administration tests with rats and mice, there was no evidence of carcinogenicity in male and female rats and male mice, but rare kidney neoplasms of tubular cell adenoma and adenocarcinoma occurred in female mice, and it is concluded that there was equivocal evidence of carcinogenicity (NTP TR333 (1988)). It was classified in "Carc. Cat. 3; R40" in EU DSD classification and "Carc. 2 H351" in EU CLP classification.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, it is described that vascular changes in the liver, lung, and brain as a result of venous congestion were observed at a dose equal to the LD50 value (8,730 mg/kg) after oral administration to rats (NTP TR333 (1988)), but the details are unknown.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In 13-week diet administration tests with rats and mice, nephropathy (mainly dilated tubules, degeneration, necrosis, and regeneration of the tubular epithelial cells) and increased relative weights of the liver were observed at the doses (5,000-40,000 ppm, equivalent to 250-1,000 mg/kg/day) above the guidance value range for Category 2. And in rats, effects on the bone marrow (hematopoietic atrophy or hypoplasia), testis (hypospermatogenesis), and spleen (lymphoid depletion) were also found (NTP TR333 (1988)). Therefore, it corresponds to "Not classified" in the oral route. However, because of no toxicity information on the other routes, the classification is not possible due to lack of data.
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 48-hour LC50 = 0.30-0.68 mg/L for crustacea (Daphnia magna) (CICADs 9, 1998).
11	Hazardous to the aquatic environment (Long-term)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1977)), and 21-day NOEC = 0.02 mg/L for crustacea (Daphnia magna) (CICADs 9, 1998). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to being not rapidly degradable (a degradation rate by BOD: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1977)), and 96-hour LC50 = 0.44-0.74 mg/L for fish (Oncorhynchus mykiss) (CICADs 9, 1998). From the above results, it was classified in Category 1.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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