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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	1308-14-1
Chemical Name	Chromium hydroxide hydrate
Substance ID	H26-B-035, R-014
Classification year (FY)	FY2014
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition)
7	Flammable solids	Not classified	- -	-	-	Not combustible (ICSC (2003)).
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	- -	-	-	Not combustible (ICSC (2003)).
11	Self-heating substances and mixtures	Not classified	- -	-	-	Not combustible (ICSC (2003)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	From information that it is insoluble in water (ICSC (2003)), it is confirmed that it does not react vigorously with water.
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition)
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound containing oxygen (but not halogen), but the classification is not possible due to no data.
15	Organic peroxides	Not applicable	- -	-	-	Inorganic compound
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on a report (IUCLID (2000)) of an LD50 value for rats of >5,000 mg/kg (OECD TG 401), it was classified as "Not classified." Since a new information source (IUCLID (2000)) was added, the category was revised.
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	Since there is a report of an LC0 value (4 hours) for rats of >13.3 mg/L (OECD TG 403) (IUCLID (2000)), it was classified as "Not classified." Besides, because there is no data on vapor pressure and it cannot be assumed to be in the gas or vapor state, it was regarded as a test with the dust and its reference value was applied. Since the new information source (IUCLID (2000)) was added, and the category was revised.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. In humans, there is 1 report that dermatitis was caused by exposure to trivalent chromium compounds and another report that it was not (EHC 61 (1988), ACGIH (7th, 2001)).
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there is a description that particles of trivalent chromium compounds may irritate the eyes (Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010)).
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	Japan Society For Occupational Health (JSOH) classified chromium compounds including this substance in occupational sensitizers to the airway Group 2 (OEL Documentations (Japan Society For Occupational Health (JSOH), 1989)). On the other hand, it is described that there is at present no unequivocal evidence to show that exposure to trivalent chromium compounds has induced occupational asthma (CICAD 76 (2009)). According to the revised GHS classification guidance for the Japanese government, it is described that Group 1 and Group 2 in the Japan Society For Occupational Health (JSOH) are treated as equivalent to 1A. However, since this substance itself is not specified in OEL Documentations (Japan Society For Occupational Health (JSOH), 1989), subcategorization was not performed in this classification and it was classified in Category 1.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Japan Society For Occupational Health (JSOH) classified chromium compounds including this substance in occupational skin sensitizers Group 1 (OEL Documentations (Japan Society For Occupational Health (JSOH), 1989)). In addition, there is a report that after application of trivalent chromium to guinea pigs, sensitization was observed (EHC 61 (1988)). Moreover, there is a description that although trivalent chromium may act as an ultimate haptenic determinant, its poor skin penetration limits the sensitizing ability of trivalent chromium salts (CICAD 76 (2009)). According to the revised GHS classification guidance for the Japanese government, it is described that Group 1 and Group 2 in the Japan Society For Occupational Health (JSOH) are treated as equivalent to 1A. However, since this substance itself is not specified in OEL Documentations (Japan Society For Occupational Health (JSOH), 1989), subcategorization was not performed in this classification and it was classified in Category 1.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There are no in vivo data on this substance. As for in vitro data, there is only a negative result in a DNA damage test with Escherichia coli using chromium hydroxide (CICAD 76 (2009)).
6	Carcinogenicity	Classification not possible	- -	-	-	Since it was classified in Group 3 (as Chromium (III)) by IARC (1990), in A4 (as Metal and Cr III compounds) by ACGIH (2008) and as D (Chromium (III), as insoluble salts) by EPA (1998), it was classified as "Classification not possible."
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	There is little information on this substance, only a report that vomiting, abdominal tenderness and anaemia were observed in a woman who ingested 5 g of chromium hydroxide (Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010)). Classification not possible due to lack of data.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data.
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Classification not possible	- -	-	-	No data available.
11	Hazardous to the aquatic environment (Long-term)	Classification not possible	- -	-	-	No data available.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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