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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	79-04-9
Chemical Name	Chloroacetyl chloride
Substance ID	H26-B-037, -
Classification year (FY)	FY2014
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Not classified	- -	-	-	Not combustible (ICSC (1998))
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	Not combustible (ICSC (1998))
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Not classified	- -	-	-	Not combustible (ICSC (1998))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P361+P364 P264 P270 P321 P330 P405 P501	Based on a report of an LD50 value of 208 mg/kg for rats (Environmental Risk Assessment for Chemical Substances Vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010), ACGIH (7th, 2001)), it was classified in Category 3. A new information source (Environmental Risk Assessment for Chemical Substances Vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010)) was added, and a low-priority information source was deleted, therefore, the text was reviewed.
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, although there was a report of an LD50 value of 662 mg/kg for rats (GESTIS (Access on July 2014), RTECS (2009), Chemical Substance Hazard Data (CERI, 2002)), they were low priority information sources (List 3), therefore, it was not adopted for classification.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	Based on a report of an LC50 value (4 hours) of 1,000 ppm for rats (ACGIH (7th, 2001)), it was classified in Category 3. Besides, the LC50 value was lower than 90% of the saturated vapor concentration (24,679 ppm), the reference value in units of ppm was applied as a vapour without a mist. Besides, there were reports of LC50 values (1 hour) of >747 ppm (converted 4-hour equivalent value: >374 ppm) (ACGIH (7th, 2001)) and 660 ppm (converted 4-hour equivalent value: 330 ppm) (Environmental Risk Assessment for Chemical Substances Vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010), ACGIH (7th, 2001)) for rats, however, the 4-hour data was prioritized in the classification according to the GHS Classification Guidance for the Japanese Government. The category was changed by adding a new information source (Environmental Risk Assessment for Chemical Substances Vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010)).
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	Based on a report that it was corrosive when the undiluted liquid of this substance was applied to rabbits for 24 hours (HSDB (Access on June 2014)), and on a description that this substance was corrosive to the skin (ACGIH (7th, 2001), Environmental Risk Assessment for Chemical Substances Vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010)), it was judged as Category 1. Besides, this substance was classified as "C; R35" in the EU DSD classification, and as "H314 Skin Corr. 1A" in the EU CLP classification. The category was changed by adding information.
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	There is a description that in an eye irritation test in which 0.5 mL of the undiluted liquid of this substance was applied to rabbits for 5 or 30 seconds, it was corrosive and the irritation score was 110, the maximum value (HSDB (Access on June 2014)). In addition, since there are descriptions that this substance was corrosive to the eyes (ACGIH (7th, 2001), Environmental Risk Assessment for Chemical Substances Vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010)) and that this substance induced lacrimation, and its vapor was very strongly irritating to the eyes and respiratory tract (ACGIH (7th, 2001)), it was classified in Category 1. The category was changed by adding information.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There were no in vivo data. As for in vitro, it was negative in a bacterial reverse mutation test and a chromosome aberration test and a sister chromatid exchange test with cultured mammalian cells (ACGIH (7th, 2001)).
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs, cardiovascular system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	This substance was corrosive and induced lacrimation, and in humans, it was corrosive and strongly irritating to the respiratory tract. It caused a burning sensation, abdominal pain, diarrhea and shock or collapse from oral ingestion, and cough, labored breathing, breathlessness, sore throat, burning sensation and cyanosis by inhalation. On inhalation of vapors or aerosols, pulmonary edema may be caused. The cardiovascular system may be affected. Other than these, dyspnea, effects on the gastrointestinal tract, cardiorespiratory arrest and promotion of ventricular arrhythmia were reported (Environmental Risk Assessment for Chemical Substances Vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010), ACGIH (7th, 2001)). As for experimental animals, strong irritation to the respiratory tract was observed. Significant histopathological findings in mice were damage to the respiratory tract and lungs. In addition, shallow breathing, labored breathing, lethargy, salivation and congestion of the lung and nasal tissues were reported by inhalation exposure in rats (ACGIH (7th, 2001)). These findings were within the guidance value range corresponding to Category 1. From the above, it was classified in Category 1 (respiratory organs, cardiovascular system).
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	There were no hazardous findings in humans by repeated exposures. According to descriptions that in tests in which rats, mice, and hamsters were exposed to the vapor of this substance by inhalation for 4 weeks, irritation symptoms to the eye and respiratory organs were observed in all animal species at or above 0.5 ppm (2.3 mg/m3), and histopathological changes in the nasal cavity (inflammation, hypertrophy, hyperplasia and squamous metaplasia in the respiratory epithelium) were observed in rats and mice (hamsters were not examined histopathologically) (ACGIH (7th, 2001), Environmental Risk Assessment for Chemical Substances Vol.8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010)), it was classified in Category 1 (respiratory organs) since the effects on the respiratory organs were observed at or above the concentration corresponding to Category 1 (converted guidance value: 0.00071 mg/L/6 hours).
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment (Long-term)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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