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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	109-89-7
Chemical Name	Diethylamine
Substance ID	H26-B-042, -
Classification year (FY)	FY2014
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It was classified in Category 2 based on a flash point of -28 deg C (closed cup) and a boiling point of 55.5 deg C (ICSC (2008)). Besides, it is classified in Class 3, Subsidiary Risk 8, PG II (UN1154) in UNRTDG.
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 312 deg C (ICSC (2008)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P361+P364 P264 P270 P321 P330 P405 P501	There are 2 reports of LD50 values of 108 mg/kg (ACGIH (7th, 2013)) and 540 mg/kg (PATTY (6th, 2012), OEL Documentations (Japan Society For Occupational Health (JSOH), 1989)) for rats. Since they corresponded to Category 3 and Category 4 one by one, it was classified in Category 3 to which the lowest LD50 value corresponded.
1	Acute toxicity (Dermal)	Category 3	Danger	H311	P302+P352 P280 P312 P321 P361 P364 P405 P501	Based on reports of LD50 values of 580 mg/kg (PATTY (6th, 2012)), 820 mg/kg (ACGIH (7th, 2013), 0.82 mL/kg (OEL Documentations (Japan Society For Occupational Health (JSOH), 1989)) and 580-820 mg/kg (NTP TR 566 (2011)) for rabbits, it was classified in Category 3.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Category 4	Warning	H332	P304+P340 P261 P271 P312	Based on a report of an LC50 value (4 hours) of 4,000 ppm for rats (PATTY (6th, 2012), NTP TR 566 (2011), OEL Documentations (Japan Society For Occupational Health (JSOH), 1989)), it was classified in Category 4.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	There are multiple reports that it was corrosive in tests with rabbits (ACGIH (7th, 2013), IUCLID (2000)). Additionally, there is a description that this substance was severely irritating, and the skin of the contact site was damaged (OEL Documentations (Japan Society For Occupational Health (JSOH), 1989)). From the above, it was classified in Category 1. Besides, this substance was classified as "Skin" by ACGIH, as "C:R35" in the EU DSD classification, and as "H314 Skin Corr. 1A" in the EU CLP classification.
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	There is a report that it was corrosive in a test with rabbits (ACGIH (7th, 2013)). There is a report that strong eye damage was observed by accidental contact in humans (ACGIH (7th, 2013)), and there is a description that the mucosa was damaged by contact (OEL Documentations (Japan Society For Occupational Health (JSOH), 1989)). Moreover, this substance was classified in Category 1 for the skin corrosion/irritation in this classification. From the above, it was classified in Category 1.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there is a report of no sensitization in a mouse ear swelling test (IUCLID (2000), ACGIH (7th, 2013)). However, these data were judged as insufficient for classification since details such as test conditions were unknown.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was all negative in a dominant lethal test with rats, micronucleus tests with rats and mice and an unscheduled DNA synthesis test on the kidney of a rat (ACGIH (7th, 2001), NTP DB (Access on July 2014), NTP TR566 (2011), IUCLID (2000)). As for in vitro, it was negative in bacterial reverse mutation tests (NTP DB (Access on July 2014), NTP TR566 (2011), ACGIH (7th, 2001), IUCLID (2000)). From the above, although there were no in vitro data from a chromosomal aberration test and a gene mutation test, it was negative in in-vivo tests, therefore, it was judged not to be mutagenic in vivo. Besides, there is information that diethylamine showed mutagenicity when administered with nitrous acid (DFGOT vol. 1 (1991)).
6	Carcinogenicity	Classification not possible	- -	-	-	Since it was classified in A4 in the ACGIH (7th, 1994), it was classified as "Classification not possible."
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	The main effects of this substance are local effects due to corrosivity and respiratory tract irritation (OEL Documentations (Japan Society For Occupational Health (JSOH), 1989), PATTY (6th, 2012), SIAP (2013), HSDB (Access on June 2014)). In humans, there is a report that it caused wheezing, breathing difficulty, upper respiratory tract damage, pulmonary edema and pneumonia by the inhalation exposure of the vapour. In a case in which the face was exposed to accidental squirting of this substance, intense lung irritation was observed accompanied by severe dyspnea and pneumonia. On oral exposure, it may cause esophagus burns, wheezing, salivation and vomiting (ACGIH (7th, 2013), HSDB (Access on June 2014)). Although there are few data on experimental animals, it was irritating to the respiratory tract like in humans, and there is a report of a decrease in the respiration rate in mice (ACGIH (7th, 2013)). Since the fatty liver degeneration described in the previous classification was information from RTECS in List 3, it was not adopted. From the above, although respiratory tract irritation was the main effect, lung damage was also observed, therefore, it was classified in Category 1 (respiratory organs).
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	There are no adverse findings by repeated exposure in humans. As for experimental animals, in NTP tests in which rats and mice were exposed by inhalation to the vapour of this substance for 17 days, 14 weeks or 105 weeks, damage to the respiratory organs (inflammation, hyperplasia and squamous metaplasia of the nasal respiratory epithelium, atrophy of the olfactory epithelium, inflammation and necrosis of the nasal turbinate) was observed at or above concentrations corresponding to Category 1 (31-1,255 ppm (converted guidance value: 0.071-0.188 mg/L/6 hours)) (NTP TR566 (2011), ACGIH (7th, 2013)). Besides, in 14-week inhalation exposure tests with rats and mice in NTP tests, a decrease in sperm motility was observed at the concentration (32 ppm: 0.096 mg/L/6 hours) corresponding to Category 1. Additionally, in mice, the prolonged estrous cycle was observed at the concentration (125 ppm: 0.375 mg/L/6 hours) corresponding to Category 2. However, there was no change in sperm count, and no histological abnormality was observed in the genetic organs in males and females. Moreover, in the ACGIH, there is a description that in a test in which rabbits were exposed to the vapour of this substance by inhalation for 6 weeks, in addition to the respiratory organs, parenchymatous degeneration of the liver and nephritis were observed at concentrations (50-100 ppm: 0.080-0.16 mg/L/6 hours (converted guidance value)) corresponding to Category 1 (ACGIH (7th, 2013)), therefore, the liver and kidney may be the target organs. However, this original source was old (1951), no findings of concern for effects on the liver or kidney were shown in subsequent studies with rats and mice. Therefore, it was judged that the finding of tissue changes of the liver and kidney in rabbits was inappropriate for classification. From the above, it was classified in Category 1 (respiratory organs).
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment (Long-term)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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