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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	287-92-3
Chemical Name	Cyclopentane
Substance ID	H26-B-044, R-018
Classification year (FY)	FY2014
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It was classified in Category 2 based on a flash point of -37 deg C (closed cup) and a boiling point of 49 deg C (ICSC (2011)). Besides, it is classified in Class 3, PG II (UN1146) in UNRTDG.
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 320 deg C (ICSC (2011)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to low-temperature-boiling liquids are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on a report of an LD50 value of >5,000 mg/kg (SIDS (2010)) for rats, it was classified as "Not classified."
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	There were reports of LC50 values (4 hours) of >5.62 mg/L (1,961 ppm) and >25.3 mg/L (8,830 ppm) (SIDS (2010)) for rats. However, since it is not possible to identify the category to which these values corresponded, it was classified as "Classification not possible." Besides, since the LC50 values were lower than 90% of the saturated vapor concentration (444,225 ppm), the reference value in units of ppm was applied as a vapour without a mist. A new information source (SIDS (2010)) was added, and the classification was revised.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Not classified	- -	-	-	In a skin irritation test (OECD TG 404) with rabbits, no skin reaction (irritation score: 0.0) was observed, and it was determined that it was not irritating (SIDS (2010)). In addition, in a test with guinea pigs, there is a report that slight erythema was observed (Patty (2012), SIDS (2010)). From the above results, it was judged to be "Not classified" (Category 3 in UN GHS classification). Since the information described in the previous classification was absent from the Lists in the GHS classification guidance for the Japanese government, it was deleted, and test information according to any test guidelines was added, and the category was changed.
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	There were 2 reports of eye irritation tests (equivalent to OECD TG 405) with rabbits. In one test, a test with eyes washed after application, conjunctival redness was observed 1 hour after application (6/6 animals), but this resolved 72 hours after application (SIDS (2010)). In the other test (unwashed), although conjunctival redness (6/6 animals), iritis and conjunctival edema (1/6 animals) were observed, these disappeared 4 days after application (SIDS (2010)). From the above results, it was judged to be Category 2B.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in micronucleus tests with mouse erythrocytes (SIDS (2010)). As for in vitro, it was negative in bacterial reverse mutation tests (SIDS (2010), NTP DB (Access on July 2014)), and it was positive only with non-metabolic activation systems in a mouse lymphoma test with cultured mammalian cells and a chromosomal aberration test with human lymphocytes (SIDS (2010)). From the above, this substance was determined not to be mutagenic in vivo.
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 3 (respiratory tract irritation, narcotic effects)	Warning	H335 H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	This substance was irritating to the respiratory tract (SIDS (2010)). As for experimental animals, upper respiratory tract irritation and anesthetic effects were observed. In addition, effects of central nervous system depression were also observed, and by inhalation or dermal exposure, excitement, loss of equilibrium, stupor, coma and, rarely, respiratory failure occurred. By the oral ingestion, irritation of the gastrointestinal tract, nausea and vomiting were the main symptoms. By inhalation, central nervous system depression, loss of reflexes and lethality were reported at 110 mg/L (ACGIH (7th, 2001), HSDB (Access on June 2014), PATTY (6th, 2012), SIDS (2010)). In addition, by an oral administration to mice, there is a description that there was a mild-moderate respiration hazard (PATTY (6th, 2012)). The effects of central nervous system depression on experimental animals were observed exceeding the range of Category 2. From the above, it was classified in Category 3 (respiratory tract irritation, narcotic effects).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	There was no data available for classification in humans. As for experimental animals, in a test in which rats were exposed by inhalation to this substance (presence state: presumed to be the vapour) for 28 days, although slight and reversible effects on the blood system (decreased erythrocyte count, variation of erythrocyte parameters) were observed at a higher concentration (5.29 mg/L: converted guidance value (1.65 mg/L/6 hours)) corresponding to "Not classified," but in a 13-week inhalation exposure test, no toxic effects including blood effects were observed even at a further higher concentration (30 mg/L) (SIDS (2010)). Therefore, although it was considered to be corresponding to "Not classified" by the inhalation route, there was no toxicity information by the other routes, and it was classified as "Classification not possible" due to lack of data.
10	Aspiration hazard	Category 1	Danger	H304	P301+P310 P331 P405 P501	Since this substance is a hydrocarbon and has a kinematic viscosity of 0.59 mm2/sec. (20 deg C, calculated value by CERI), it was classified in Category 1.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 3	- -	H402	P273 P501	It was classified in Category 3 from 48-hour EC50 = 10.5 mg/L for crustacea (Daphnia magna) (SIDS, 2008).
11	Hazardous to the aquatic environment (Long-term)	Category 3	- -	H412	P273 P501	Reliable chronic toxicity data were not obtained. Due to being not rapidly degradable (a 28-day degradation rate in a test according to OECD 301F: 0% (SIDS, 2008)), and 48-hour EC50 = 10.5 mg/L for crustacea (Daphnia magna) (SIDS, 2008), it was classified in Category 3.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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