GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 540-59-0
Chemical Name 1,2-Dichloroethylene
Substance ID H26-B-047, -
Classification year (FY) FY2014
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Category 2


Danger
H225 P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
It was classified in Category 2 based on a flash point of 6 deg C (closed cup) and a boiling point of 55 deg C (ICSC (2003)).
Besides, it is classified in Class 3, PG II (UN1150) in UNRTDG.
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Type G
-
-
- - There is a chemical group associated with self-reactive properties (unsaturated bond) present in the molecule, but commonly distributed products contain a stabilizer. This substance is classified in Class 3, PG II (UN1150) in UNRTDG. Therefore, the stabilized one was classified in Type G.
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 460 deg C (ICSC (2003)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to low-temperature-boiling liquids are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 4


Warning
H302 P301+P312
P362+P364
P264
P270
P330
P501
Based on a report of an LD50 value of 770 mg/kg for rats (HSDB (Access on June 2014), GESTIS (Access on July 2014)), it was classified in Category 4. By adding new information sources (HSDB (Access on June 2014), GESTIS (Access on July 2014)), the sentences were reviewed.
1 Acute toxicity (Dermal) Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, this substance is a mixture of the trans-isomer and cis-isomer, while trans-1,2-dichloroethylene (CAS RN 156-60-5) corresponds to "Not classified" and cis-1,2-dichloroethylene (CAS RN 156-59-2) corresponds to "Classification not possible."
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not classified
-
-
- - This substance is a mixture of the trans-isomer and cis-isomer, and there were no data on this substance (the mixture of isomers) itself. Since both trans-1,2-dichloroethylene (CAS RN 156-60-5) and cis-1,2-dichloroethylene (CAS RN 156-59-2) were classified as "Not classified," it was classified as "Not classified." Besides, because the LC50 values were lower than 90% of the saturated vapor concentration (348,470 ppm), the reference value in units of ppm was applied as a vapour without a mist.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, as for trans-1, 2-dichloroethylene (CAS RN 156-60-5), there are reports that after 24-hour occlusive application of 0.5 mL of the undiluted liquid of this substance, mild to moderate erythema was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (1996), IRIS TR (2010)), and that after applying 5,000 mg/kg to rabbits, although severe skin irritation was observed, reversibility was unknown (ATSDR (1996)). Moreover, also in humans, there is a description that it was irritating to the skin (Environmental Risk Assessment for Chemical Substances Vol.4 (Ministry of the Environment, 2005)). Since the evidence in the previous classification was from the data on trans-1, 2-dichloroethylene, it was not adopted.
3 Serious eye damage/eye irritation Category 2A


Warning
H319 P305+P351+P338
P337+P313
P264
P280
Based on reports on exposure to humans that pain in the eye with a burning sensation was observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)) and that moderate irritation was observed (OEL Documentations (Japan Society For Occupational Health (JSOH), 1970)), it was classified in Category 2A.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a micronucleus test with mouse peripheral blood erythrocytes (IRIS TR (2010)). As for in vitro, it was negative in bacterial reverse mutation tests and a chromosomal aberration test with cultured mammalian cells, and it was positive in a micronucleus test with cultured human cells and a sister chromatid exchange test (IRIS TR (2010), NTP DB (Access on July 2014)).
6 Carcinogenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory organs, liver), Category 3 (narcotic effects)



Danger
Warning
H370
H336
P308+P311
P260
P264
P270
P321
P405
P501
P304+P340
P403+P233
P261
P271
P312
In humans, inhalation exposure caused vertigo, nausea and severe narcotic effects, and a fatal case was reported after inhalation of the vapour of this substance in a small enclosure (OEL Documentations (Japan Society For Occupational Health (JSOH), 1970), ACGIH (7th, 2001), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)).
As for experimental animals, there are reports that, in a test in which rats were exposed by inhalation to 63.44 mg/L of a mixture of the trans- and cis-isomers, central nervous system depression, balance problems and prostration were observed, that narcotic effects and effects on the central nervous system were observed by inhalation with rats, and that severe pulmonary hyperemia, alveolar septal distention and pulmonary infiltration were observed by inhalation at 3.97 mg/L and 11.90 mg/L with rats (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). In addition, there was a report of fatty degeneration of the hepatic lobules and Kupffer cells (ACGIH (7th, 2001)). In a report in which inhibition of propagation and maintenance of the electrically evoked seizure discharge was studied with rats and mice by inhalation exposure to this substance, it was described that the air concentration evoking a 30% depression in the duration of hindlimb tonic extension in rats was 1,810 ppm (converted value: 7.18 mg/L), and that the concentration evoking a 30% increase in the latency for hindlimb tonic extension in mice was 3,400 ppm (converted value: 13.48 mg/L) (ATSDR (1996)). Besides, as for the above findings of experimental animals, effects on the respiratory organs and liver were observed within the guidance value range of Category 1.
From the above, it was classified in Category 1 (respiratory organs, liver), Category 3 (narcotic effects). Besides, the description in the previous classification "as for experimental animals, "a 45% decrease in the duration of immobility in the swimming test" (ATSDR (1996))" was deleted from the evidence data, since ATSDR described that "the neurological significance of changes in the duration of swimming immobility is not known."
9 Specific target organ toxicity - Repeated exposure Classification not possible
-
-
- - There was no information on humans. As for experimental animals, when male rats were administered by gavage of a mixture of 50:50 (cis-:trans-) isomers at 485 mg/kg/day (162 mg/kg/day (converted guidance value)) for 30 days, an increase in the relative liver weight and blood findings (such as decreased erythrocyte count and hemoglobin concentration) were observed (IRIS TR (2010), ATSDR (1996)). However, it was a test with only 1 dose, and it is unknown whether there are effects within or lower than the dose range of Category 2. In addition, by the inhalation route, although there are reports that, in a test in which rats, rabbits, guinea pigs and dogs were exposed to a mixture of 58:42 (cis-:trans-) isomers by inhalation for 6 months, increased liver weight and/or kidney weight were observed in rats and rabbits at high concentrations exceeding Category 2 (IRIS TR (2010), ATSDR (1996)), effects within or lower of concentration range of Category 2 is similarly unknown. As in the above, since there were no available test data for classification by the oral and inhalation route, it was impossible to classify due to lack of data.
Besides, although it was classified in Category 2 (hemal system) in the previous classification based on the description in ATSDR (1996), the description of "a significant depression of the total blood cell count, the red blood cell count, hemoglobin, and hematocrit" was the finding by administration at a dose of 485 mg/kg/day for 30 days, and the converted dose according to the GHS Classification Guidance for the Japanese Government corresponded to "Not classified." Therefore, Category 2 in the previous classification was wrong.

As reference information of not a mixture but the isomers themselves, there were no available data on the trans-isomer for classification. Therefore, it was classified as "Classification not possible" in this current classification. On the other hand, as for the cis-isomer, only a test result by the oral route is an oral dose test with rats, which showed increased liver weight and kidney weight without tissue changes at doses equivalent to Category 2 (IRIS TR (2010)), the evidence was inadequate to classify in Category 2 (liver, kidney). Since there were no toxic data by the inhalation route, and similarly due to lack of data for the cis-isomer, it was reasonable to be classified as "Classification not possible."
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) -
-
-
- - -
11 Hazardous to the aquatic environment (Long-term) -
-
-
- - -
12 Hazardous to the ozone layer -
-
-
- - -


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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