Item | Information |
---|---|
CAS RN | 123-19-3 |
Chemical Name | Di-n-propyl ketone |
Substance ID | H26-B-048, - |
Classification year (FY) | FY2014 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 3 |
Warning |
H226 |
P303+P361+P353
P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
It was classified in Category 3 based on a flash point of 34 deg C (closed cup) (GESTIS (Access on July 2014)). Besides, it is classified in Class 3, PG III (UN2710) in UNRTDG. |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 420 deg C (GESTIS (Access on July 2014)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on the report that an LD50 value of 3.73 mL/kg (=3.049 mg/kg which was the converted value using 0.8174 g/cm3 at 20 deg C (Lide (85th, 2004))) for rats (ACGIH (7th, 2001)), it was classified as "Not classified" (Category 5 in UN GHS classification). |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on the report that an LD50 value of 5.66 mL/kg (=4,626 mg/kg which was the converted value using 0.8174 g/cm3 at 20 deg C (Lide (85th, 2004))) for rabbits (ACGIH (7th, 2001)), it was classified as "Not classified" (Category 5 in UN GHS classification). |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Category 4 |
Warning |
H332 |
P304+P340
P261 P271 P312 |
Based on a report of an LC50 (6 hours) value of 2,690 ppm (converted 4-hour equivalent value: 3,295 ppm) for rats (PATTY (6th, 2012), ACGIH (7th, 2001)), it was classified in Category 4. Besides, since the LC50 value was lower than 90% of the saturated vapor concentration (6,910ppm), the reference value in units of ppm was applied as a vapour without a mist. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | Based on descriptions that mild irritation was found in tests with rabbits or guinea pigs, and that after application to humans, mild irritation might occur, it was classified as "Not classified" (Category 3 in UN GHS classification). The category was revised according to the revision of the GHS classification guidance for the Japanese Government. |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 |
P305+P351+P338
P337+P313 P264 P280 |
There are reports that mild irritation was noted in an eye irritation test with rabbits (PATTY (6th, 2012)), and that when rats were exposed to this substance at 2,000 ppm for 4 hours, eye irritation was observed (ACGIH (7th, 2001)). In addition, there is a report that after single application to humans, mild irritation might occur (PATTY (6th, 2012)). From the above results, it was classified in Category 2. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 3 (respiratory tract irritation, narcotic effects) |
Warning |
H335
H336 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
In humans, based on descriptions that respiratory tract irritation was caused by inhalation exposure, and that depressed consciousness was caused at high concentrations (ACGIH (7th, 2001), PATTY (6th, 2012)), it was considered to have narcotic effects. In experimental animals, there is a description of decreased respiration at 400 ppm, hypoactivity at 825 ppm, narcotic effects and death at 1,600 ppm and 3,220 ppm, and mucous membrane irritation at 2,000 ppm by inhalation exposure of rats (ACGIH (7th, 2001), PATTY (6th, 2012)). The effects on experimental animals were judged to be due to irritation and narcotic effects, and it was classified in Category 3 (respiratory tract irritation, narcotic effects). |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - |
There was no information in humans. As for experimental animals, although increases in relative weights of the liver and kidney, hepatocyte hypertrophy, and irritation and hyperkeratosis of the nonglandular gastric epithelium were noticed in a 12-week gavage study with rats administered at 1,000 mg/kg/day of this substance (5 days/week) (PATTY (6th, 2012), HSDB (Access on June 2014)), there are no test data that clearly show the effects through the oral route including this study, at or lower than the dose range of Category 2. On the other hand, on inhalation exposure with rats to this substance at 1,200 ppm (5,592 mg/m3) (presumed to be a vapor) for 2 weeks, no abnormalities were observed except that a decreased response to stimulation during exposure and marginal liver enlargement in necropsy were observed (ACGIH (7th, 2001), HSDB (Access on June 2014)). Although the concentration where effects were observed corresponded to within the range of Category 2 (converted guidance value: 0.86 mg/L/6 hours), it was a short-term exposure test with only one concentration, and it was difficult to confirm with the original source (unpublished company data), therefore, the data was judged to be inappropriate for classification. Therefore, it was concluded that classification was not possible due to lack of data. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | This substance is a ketone composed of no more than 13 carbon atoms and had a kinematic viscosity of 0.0091 mm2/s (20 deg C, calculated by CERI), corresponding to Category 2. According to the GHS Classification Guidance for the Japanese Government, it was classified as "Classification not possible." |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment (Long-term) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
|