Item | Information |
---|---|
CAS RN | 818-08-6 |
Chemical Name | Dibutyltin oxide |
Substance ID | H26-B-051, R-022 |
Classification year (FY) | FY2014 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive properties. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition) |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
7 | Flammable solids | Classification not possible |
- |
- | - | It is described in ICSC (1999) that it is combustible, but the classification is not possible due to no data. |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 279 deg C (ICSC (1999)). |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | Because there is the observation result that it is insoluble in water (ICSC (1999)), it is estimated that it does not react vigorously with water. |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine), and the oxygen is chemically bonded to the element other than carbon or hydrogen (Sn). However, the classification is not possible due to no data. |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 |
P301+P310
P361+P364 P264 P270 P321 P330 P405 P501 |
There are three reports of LD50 values of 172 mg/kg, 260 mg/kg (SIDS (2009)), and 520 mg/kg (EHC 15 (1980)) for rats. Since two cases correspond to Category 3, and one case corresponds to Category 4, it was classified in Category 3, to which the larger number of values corresponds. Besides, although there are also reports of 44.9 mg/kg and 50 mg/kg (Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010)), since the information source is RTECS and these data are not adopted in SIDS (2009), they were not adopted for this classification because of insufficient reliability. New information sources were added (Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010), SIDS (2009), and EHC 15 (1980)), and the category was revised. |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on the reports of an LD50 value of > 2,000 mg/kg (SIDS (2009)) for rats, and an LD50 value of > 2,000 mg/kg (Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010)) for rabbits, it was classified as "Not classified." New information sources (Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010), SIDS (2009)) were added, and the category was revised. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 |
P302+P352
P332+P313 P362+P364 P264 P280 P321 |
As a result of occlusive application of 0.5 mL of the undiluted liquid of this substance to rabbits for 4 hours, very mild to mild edema and erythema were observed. There is a report that the edema resolved within 72 hours but the erythema persisted throughout the observation period (14 days) (SIDS (2009)). In addition, there is a description that this substance may irritate the skin and cause burns and pain (Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010)). From the results above, it was classified in Category 2. The information in SIDS (2009) was added, and the category was revised. Besides, although it was considered as mild irritation for this study in SIDS (2009), it was classified based on the persistent erythema. |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
There is a report that in an eye irritation test with rabbits (OECD TG 405), the maximum score was 19.5 (maximum value 110), and the corneal edema, corneal neovascularization, and formation of scleral veins were observed, and the irritation of the cornea persisted after 21 days (SIDS (2009)). From the result above, it was classified in Category 1. The classification was revised due to this update of the information. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. As for in vitro, it was negative in bacterial reverse mutation tests (Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010), SIDS (2009)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
7 | Reproductive toxicity | Category 1B |
Danger |
H360 |
P308+P313
P201 P202 P280 P405 P501 |
In a teratogenicity study by the oral route (gavage) with rats, at a dose (19.9 mg/kg) where no maternal toxicity was observed, external malformations (cleft mandible, cleft lower lip, ankyloglossia, schistoglossia, exencephaly) and skeletal malformations (fused mandibula, cranial hypoplasia, fused ribs, absence of ribs, fused vertebral arches, cleft maxilla) were observed (SIDS (2009)). In the previous classification, since there was no information on maternal toxicity, it was classified in Category 2. However, since it was found that maternal toxicity was not observed, it was classified in Category 1B. |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system), Category 3 (respiratory tract irritation) |
Danger Warning |
H370
H335 |
P308+P311
P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
This substance is irritating to the respiratory tract. It may also affect the central nervous system and cause dysfunction, which may lead to death. Inhalation and oral ingestion may cause headaches, tinnitus, memory loss and disorientation (Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010)). In experimental animals, there is a description that as a result of oral administration of 164-176 mg/kg of this substance to rats, substance-related behavioral changes such as dyspnea, sedation, diarrhea, and increased aggressiveness were suggested (SIDS (2009)). There are no relevant findings on effects on the lungs and liver. Effects on experimental animals were observed within the guidance value range for Category 1. From the above, since this substance is considered to have effects on the central nervous system and respiratory tract irritation, it was classified in Category 1 (central nervous system) and Category 3 (respiratory tract irritation). |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - |
There are no findings on repeated exposure for this substance, and therefore, classification is not possible due to lack of data. Besides, there is a description that this substance is converted to dibutyltin dichloride (CAS: 683-18-1) in artificial gastric juice (Environmental Risk Assessment for Chemical Substances Vol.8 (Ministry of the Environment, 2010), SIDS (2009)). In the previous classification, it was classified in Category 1 (liver, kidney) by List 3 information sources, but the data estimated to be the basis was not specified in List 1 information sources. Strictly speaking, it was presumed that classification was conducted based on hazards, not of this substance but those of dibutyltin compounds which are mainly present in the test results for dibutyltin dichloride. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 |
- |
H401 |
P273
P501 |
It was classified in Category 2 from 48-hour EC50 = 1.5 mg DBTO/L for crustacea (Daphnia magna) (SIDS, 2006, CICAD 73, 2006). |
11 | Hazardous to the aquatic environment (Long-term) | Category 2 |
- |
H411 |
P273
P391 P501 |
Reliable chronic toxicity data were not obtained. Due to being not rapidly degradable (a degradation rate by BOD = 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1984)), and 48-hour EC50 = 1.5 mg DBTO/L for crustacea (Daphnia magna) (SIDS, 2006, CICAD 73, 2006), it was classified in Category 2. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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