Item | Information |
---|---|
CAS RN | 1118-46-3 |
Chemical Name | Butyltrichlorotin |
Substance ID | H26-B-053, R-070 |
Classification year (FY) | FY2014 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2010 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive properties. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 4 |
Warning |
H227 |
P370+P378
P403+P235 P210 P280 P501 |
It was classified in Category 4 based on a flash point of 81 deg C (closed-cup) (HSDB (Access on July 2014)). |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 560 deg C (GESTIS (Access on July 2014)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | Because the result of being soluble in water (GESTIS (Access on July 2014)) was obtained, it is estimated that it does not react vigorously with water. |
13 | Oxidizing liquids | Classification not possible |
- |
- | - | The substance is an organic compound containing chlorine (but not fluorine or oxygen), and the chlorine is chemically bonded to the element other than carbon or hydrogen (Sn). However, the classification is not possible due to no data. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on LD50 values for rats of 2,140 mg/kg (EHC 15 (1980)) and > 2,000 mg/kg (male and female) (SIDS (2009)), it was classified as "Not classified." |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 |
P301+P330+P331
P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
Based on a report that severe erythema, mild edema and severe tissue destruction were observed after applying 0.5 mL of an undiluted liquid of this substance to rabbits (SIDS (2009)), it was classified in Category 1. Based on the information in List 1, the category was changed. |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
There are no data on eye irritation of this substance. However, because this substance is recognized to be corrosive in the skin irritation test and classified in Category 1, it was classified in Category 1. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | As for in vivo, it was negative in a micronucleus test with mouse bone marrow cells (SIDS (2009)) and as for in vitro, bacterial reverse mutation tests showed negative or positive results, and a gene mutation test and a chromosomal aberration test with cultured mammalian cells showed negative results (SIDS (2009), ATSDR (2005), CICAD 73 (2005), NTP DB (Access on September 2014)). Therefore, it was classified as "Classification not possible." |
6 | Carcinogenicity | Classification not possible |
- |
- | - | This substance is classified in A4 by ACGIH (7th, 2001) as an organic tin compound. Therefore, it was classified as "Classification not possible." |
7 | Reproductive toxicity | Classification not possible |
- |
- | - |
In a reproduction toxicity screening test with rats by the oral route (feeding) (OECD TG 421, administered only to females), no effects on maternal general toxicity, fertility and pups were observed at the highest dose (7,500 mg/kg feed (female: 433-685 mg/kg/day)) (SIDS (2009)). In a teratogenicity test with rats by the oral route, neither maternal nor developmental toxicity was observed at the highest dose (400 mg/kg/day) (CICAD 73 (2006)). In a teratogenicity test with rats by the oral route, although lower values of fetus body weight were observed at a dose (1,500 mg/kg/day) where maternal toxicity including death (death in 5/11 animals and decreased body weight) appeared, no external malformation was observed (CICAD 73 (2006), SIDS (2009)). In a teratogenicity test with rats by the oral route, although lower values of female pups' body weight were observed at doses (903 mg/kg/day) where maternal toxicity (decreased body weight gain and decreased food consumption) appeared, no teratogenicity was observed (SIDS (2009)). Though the above results, they are screening tests, so it was classified as "Classification not possible." |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
There were reports that in an oral dose of 2,800-4,000 mg/kg to rats, apathy, emphysema, lung lesions, hemorrhagic erosion of the mucosal glands, extensive intestinal and pancreatic bleeding, and necrosis in the liver and kidney were observed, and in an oral dose of 200-6,000 mg/kg to mice, periodic respiration was shown and dilatation of the stomach, blood stains in the stomach contents, hemorrhages in the mucous membrane of the gastrointestinal tract, hyperemic intestinal wall and serosa, darkened and enlarged liver and spleen, and light red and slightly darkened kidney were macroscopically observed (SIDS (2009), EHC 15 (1980), HSDB (Access on July 2014)). In addition, there is a report that this substance shows no hepatotoxicity (ATSDR (2005)). It is described that it may be irritating to the respiratory tract as an organic tin compound (ATSDR (2005), ACGIH 7th (2001)). From the above, there was no information on this substance in humans, and the experimental animals' results were not treated as the target of categorization as in the previous classification and were not treated as the target of classification except for respiratory tract irritation. Therefore, it was classified in Category 3 (respiratory tract irritation). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
There are no hazard findings on this substance on repeated exposure for humans. As for experimental animals, in a test in which rats were dosed by feeding for 13 weeks, no toxic effects were observed at up to the upper limit dose of Category 2 (96 (male) - 101 (female) mg/kg/day), and the effects on the liver (increased weight, increased enzyme activity derived in bile acid in blood) and the hemal system (increases in reticulocyte ratio, the number of white blood cells, lymphocyte ratio, decreased MCH) were observed at the high dose corresponding to "Not classified" (SIDS (2009)). On the other hand, as for the inhalation route, in a test in which rats were exposed to the substance (average particle size: 0.98-1.7 micrometer (assumed to be the mist)) by nose-only inhalation for 4 weeks, the effects on the lung due to irritation were severe, lung discoloration, histological alveolar edema, peribronchial lymphoid cell accumulation, and accumulation of alveolar macrophages were observed at from the extremely low concentration (2.4 mg/m3 (converted guidance value: 0.00074 mg/L/6 hours)) within the range of Category 1. The effects became severe depending on the concentration, and the death case appeared at the concentration (71.3 mg/m3 (converted guidance value: 0.022 mg/L/6 hours)) slightly higher than Category 1. However, no findings to enable identification of the target organ other than the respiratory organs were obtained (SIDS (2009)). From the above, it was classified in Category 1 (respiratory organs). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 |
Warning |
H400 |
P273
P391 P501 |
It was classified in Category 1 from 72-hour ErC50 = 0.31 mg/L for algae (Desmodesmus subspicatus) (SIDS, 2009). |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
Warning |
H410 |
P273
P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly degradable (a degradation rate by BOD: 0% (SIDS, 2009)), and 72-hour ErC10 = 0.012 mg/L for algae (Desmodesmus subspicatus) (SIDS, 2009). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 due to being not rapidly degradable (a degradation rate by BOD: 0% (SIDS, 2009)), and 48-hour EC50 = 25 mg/L for crustacea (Daphnia magna) (CICADs 73, 2006). By drawing a comparison between the above results, it was classified in Category 1. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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