Item | Information |
---|---|
CAS RN | 107-49-3 |
Chemical Name | Tetraethyl pyrophosphate (TEPP) |
Substance ID | H26-B-063, - |
Classification year (FY) | FY2014 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Not classified |
- |
- | - | From a flash point of > 110 deg C (Closed cup) (GESTIS (Access on August 2014)) above 93 deg C, it was classified as "Not classified." |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | From the result that it is soluble in water (ICSC (1994)), it is estimated that it does not react vigorously with water. |
13 | Oxidizing liquids | Classification not possible |
- |
- | - | It is an organic compound which does not contain fluorine or chlorine but contains oxygen, and the oxygen is chemically bonded to the element other than carbon or hydrogen (P). However, the classification is not possible due to no data. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 1 |
Danger |
H300 |
P301+P310
P361+P364 P264 P270 P321 P330 P405 P501 |
Based on a report of an LD50 value of 1.1 mg/kg for rats (ACGIH (7th, 2007), PIM G001 (1998)), it was classified in Category 1. |
1 | Acute toxicity (Dermal) | Category 1 |
Danger |
H310 |
P302+P352
P262 P264 P270 P280 P310 P321 P361 P364 P405 P501 |
Based on reports of LD50 values of 2.4 mg/kg (male) for rats and 1.2 mg/kg for rabbits (ACGIH (7th, 2007), PATTY (5th, 2001)), it was classified in Category 1. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Category 1 |
Danger |
H330 |
P304+P340
P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Based on a report of an LC50 value (4 hours) of 6.75 mg/m3 (0.569 ppm) for rats (ACGIH (7th, 2007), PATTY (5th, 2001)), it was classified in Category 1. Besides, since the LC50 value is lower than 90% of the saturated vapor concentration (19.7 ppm), the reference value in units of ppm was applied as a vapor without a mist. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 |
P302+P352
P332+P313 P362+P364 P264 P280 P321 |
There is a description that irritation was caused by contact with skins (HSDB (Access on July 2014)). Therefore, it was classified in Category 2. |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 |
P305+P351+P338
P337+P313 P264 P280 |
Based on the description that as a result of applying this substance (2 drops of 0.1%) to human eyes, pressures in the eyeball were felt and chemical burns on the lids developed (ACGIH (7th, 2007)), and irritation occurs in contact with eyes (HSDB (Access on July 2014)), it was classified in Category 2. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system) |
Danger |
H370 |
P308+P311
P260 P264 P270 P321 P405 P501 |
Plasma and red blood cell cholinesterase inhibition was observed in humans, and blurred vision, lightheadedness, giddiness, breathlessness, weakness, excessive salivation, vomiting, frequent urination/defecation, cramps, unconsciousness, depth perception disorder, miosis, cyanosis and death were reported in accident cases of workers, etc. (ACGIH (7th, 2007), HSDB (Access on August 2014)). In experimental animals, red blood cell, plasma and brain cholinesterase inhibition was reported in oral or dermal administration to rats, and this effect was observed within the guidance value range for Category 1 (ACGIH (7th, 2007), HSDB (Access on August 2014)). Besides, PATTY adopted in the previous classification was not adopted because the description was not found. From the above, it was classified in Category 1 (nervous system). |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system) |
Danger |
H372 |
P260
P264 P270 P314 P501 |
In a clinical study evaluating the use of this substance as a treatment for myasthenia gravis, in which this substance was administered orally or parenterally to 18 normal human subjects, a rapid depression of plasma and red blood cell cholinesterase activity occurred through the parenteral route, and a similar effect in oral administration was observed at approximately 4 times the dose in parenteral administration (ACGIH (7th, 2007)). From the above, it is clear that this substance also exhibits cholinesterase inhibition like other organophosphorus substances, and although there is no direct evidence from repeated exposure in humans to this substance, nervous system toxicities were considered to be related to cholinesterase inhibition even after a single exposure, so it can be predicted that nervous system toxicities will develop after repeated exposure in humans. Therefore, it was classified in Category 1 (nervous system). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment (Long-term) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
|