NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	594-42-3
Chemical Name	Trichloromethylsulfenyl chloride
Substance ID	H26-B-072, -
Classification year (FY)	FY2014
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Not classified	- -	-	-	It is not combustible (ICSC (2003)).
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is not combustible (ICSC (2003)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (ICSC (2003)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Classification not possible	- -	-	-	It is an organic compound which does not contain fluorine or oxygen but contains chlorine, and the chlorine is chemically bonded to the element other than carbon or hydrogen (S). However, the classification is not possible due to no data.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P361+P364 P264 P270 P321 P330 P405 P501	There are reports of LD50 values of 83 mg/kg (PATTY (6th, 2012), ACGIH (7th, 2001), DFGOT vol. 1 (1991)) and 800 mg/kg (PATTY (6th, 2012)) for rats. By adopting the smaller LD50 value, it was classified in Category 3.
1	Acute toxicity (Dermal)	Category 4	Warning	H312	P302+P352 P280 P312 P321 P362 P364 P501	Based on a report of an LD50 value of 1,410 mg/kg for rabbits (PATTY (6th, 2012), ACGIH (7th, 2001), DFGOT vol. 1 (1991)), it was classified in Category 4.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on reports of LC50 values (1 hour) of 11 ppm (male) (converted 4-hour equivalent value: 5.5 ppm), 16 ppm (female) (converted 4-hour equivalent value: 8 ppm) (PATTY (6th, 2012), DFGOT vol. 1 (1991)) for rats, it was classified in Category 1. Besides, since the LC50 values were lower than 90% of the saturated vapour concentration (3,949 ppm), the reference value in units of ppm was applied as a vapour without a mist.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Based on descriptions that in a skin irritation test with guinea pigs, severe irritation was observed (PATTY (6th, 2012)), and that it shows severe irritation to the rabbit skin (PATTY (6th, 2012)), it was classified in Category 2.
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	There is a report that in an occupational exposure, bilateral blindness and corneal epithelium detachment were observed by exposure to this substance (DFGOT vol. 1 (1991)). In addition, there is a description that it was severely irritating to the eyes of rabbits (PATTY (6th, 2012)). From the above results, it was classified in Category 1. By adding findings on humans, the category was changed.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There were no in vivo data. As for in vitro, it was positive in bacterial reverse mutation tests (NTP DB (Access on September 2014)).
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	This substance is irritating to the respiratory tract (ACGIH (7th, 2001), DFGOT vol. 1 (1991)). In humans, as accidental cases and occupational exposure cases by the inhalation, oral and dermal route, by inhalation exposure, dyspnea, nausea, vomiting, tachycardia, cyanosis, convulsions, pulmonary edema and death were reported, by oral ingestion, gastrointestinal tract inflammation such as nausea, vomiting, diarrhea and abdominal pain, central nervous system depression and convulsions were reported, by the transdermal exposure, pulmonary edema, trachea necrosis, kidney nephrosis and vacuolation of centrilobular cells in the liver were reported (ACGIH (7th, 2001), DFGOT vol. 1 (1991), PATTY (6th, 2012), HSDB (Access on August 2014)). Among these findings in humans, pulmonary edema, trachea necrosis, kidney nephrosis, vacuolation of centrilobular cells in the liver were findings in death cases. As for experimental animals, there were reports of lethargy, dyspnea, labored breathing and pulmonary edema by the inhalation exposure with rats, and weakness, labored breathing, tremors, cyanosis, diarrhea, pulmonary edema by the oral administration, and there is a description that pulmonary edema in rats was observed in dead animals (ACGIH (7th, 2001), DFGOT vol. 1 (1991), PATTY (6th, 2012)). The effects on the central nervous system of experimental animals were observed at concentrations within the guidance value range for Category 1. From the above, since it is considered that this substance affects the central nervous system and respiratory organs in humans, it was classified in Category 1 (central nervous system, respiratory organs).
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	Based on descriptions that in 2 tests in which rats were exposed to the vapour of this substance by inhalation exposure for 2 weeks or 4 weeks, in the former, respiratory symptoms (nasal mucosa irritation, labored breathing), increased lung weight and pulmonary edema were observed at 1 ppm (8.7 mg/m3 (converted guidance value: 0.0013 mg/L/6 hours)), and in the latter, respiratory distress and pulmonary congestion were observed at 2 ppm (15.4 mg/m3 (converted guidance value: 0.0047 mg/L/6 hours)) (ACGIH (7th, 2001), PATTY (6th, 2012)), it was classified in Category 1 (respiratory organs).
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment (Long-term)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

To GHS Information