NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	111-84-2
Chemical Name	n-Nonane
Substance ID	H26-B-075, R-030
Classification year (FY)	FY2014
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It was classified in Category 3 based on a flash point of 31 deg C (closed cup) (ICSC (2011)). Besides, it is classified in Class 3, PG III (UN1920) in UMRTDG.
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 205 deg C (ICSC (2011)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Category 4	Warning	H332	P304+P340 P261 P271 P312	Based on an LC50 value (4 hours) of 3,200 ppm for rats (SIDS (2013), ACGIH (7th, 2012), OEL Documentations (Japan Society for Occupational Health (JSOH), 1989)), this substance was classified in Category 4. Besides, because the LC50 value was lower than 90% of the saturated vapor pressure concentration (4,146 ppm), a reference value in units of ppm was applied as a vapour without a mist.
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	Based on an LC50 (8 hours) of 23.4 mg/L (converted 4-hour equivalent value: 46.8 mg/L) for rats (SIDS (2013), ACGIH (7th, 2012)), this substance was classified as "Not classified." Besides, because the LC50 value was higher than the saturated vapour concentration (21.7 mg/L), the reference value of the mist was applied. New data sources (SIDS (2013), ACGIH (7th, 2012)) were added, and the category was revised.
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	There is a report that redness was observed, and moderate irritation was observed after 24 hours in a test in which 0.23 mL of this substance was applied to rabbits for 1 hour (Draize test) (SIDS (2013)). Based on the above result, this substance was classified in Category 2.
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	Although no report on eye irritation tests on this substance was available, it is generally described that a corneal irritation might occur (HSDB (Access on August 2014)), therefore, this substance was classified in Category 2B.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. No in vivo data was available and as for in vitro, it was negative in bacterial reverse mutation tests (SIDS (2013), ACGIH (7th, 2012), NTP DB (Access on September 2014) and HSDB (Access on August 2014)).
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 2 (central nervous system), Category 3 (respiratory tract irritation, narcotic effects)	Warning	H371 H335 H336	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	This substance was irritating to the respiration tract and showed narcotic effects at a high concentration (OEL Documentations (Japan Society for Occupational Health (JSOH), 1989)). In rats, salivation, coordination loss, tremors, and clonic and tonic convulsions after 4-hour inhalation exposure at 23 mg/L and irreversible central nervous system depression, ataxia, tremors, and convulsions by 8-hour inhalation exposure at 13.11 mg/L or higher were observed (OEL Documentations (Japan Society For Occupational Health (JSOH), 1989), SIDS (2013), ACGIH (7th, 2012)). Effects on the central nervous system were observed at concentrations corresponding to the guidance value range of Category 2. Besides, no data in humans were available. From the above, the effects of this substance were those on the central nervous system, respiratory tract irritation and narcotic effects, therefore, it was classified in Category 2 (central nervous system) and Category 3 (respiratory tract irritation, narcotic effects).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	There was no finding of a hazard by repeated exposure in humans. In experimental animals, it is reported that in a 13-week inhalation test with rats exposed to this substance (assumed as the vapour), no toxicity effects were found at up to the concentration of Category 2, and neurological symptoms (salivation, tremors and mild loss of muscle coordination) occurred at a very high concentration (8.4 mg/L/6 hours) (SIDS (2013), ACGIH (7th, 2012)). Through the oral route, in 90-day tests with rats and mice dosed by gavage, although histopathological lesions in both species were observed in the gastrointestinal tract (hyperplasia, hyperkeratosis and inflammatory changes of the mucosal epithelium) and the nasal turbinate (suppurative inflammation) at the upper limit level of Category 2 (100 mg/kg/day), no statistical differences in body weights were seen at up to the highest dose, 5,000 mg/kg/day in both species (SIDS (2013)), therefore, it is considered that these observations were not a serious effect or related to irritation from this substance. From the above, although it is considered that this substance was corresponding to "Not classified" through the oral and inhalation routes, it was classified as "Classification not possible" due to lack of data because no findings through the dermal route in animals and by repeated exposure in humans were available.
10	Aspiration hazard	Category 1	Danger	H304	P301+P310 P331 P405 P501	Since this substance is a hydrocarbon and the kinematic viscosity is <7 mm2/sec (40 deg C) (ICSC (2012)), it was classified in Category 1.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 48-hour EC50 = 0.2 mg/L for crustacea (Daphnia magna) (SIDS, 2010).
11	Hazardous to the aquatic environment (Long-term)	Category 1	Warning	H410	P273 P391 P501	Reliable chronic toxicity data were not obtained. It was classified in Category 1 due to a bioaccumulation estimate (LogPow = 5.65 (PHYSPROP Database, 2009)) and 48-hour EC50 = 0.2 mg/L for crustacea (Daphnia magna) (SIDS, 2010) although it is rapidly degradable (a degradation rate by BOD: 96% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1996)).
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

To GHS Information