Item | Information |
---|---|
CAS RN | 109-79-5 |
Chemical Name | 1-Butanethiol |
Substance ID | H26-B-082, R-035 |
Classification year (FY) | FY2014 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 2 |
Danger |
H225 |
P303+P361+P353
P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
It was classified in Category 2 based on a flash point of 2 deg C (closed cup) and a boiling point of 98 deg C (ICSC (2000)). Besides, it is classified in Class 3, PG II (UN2347) in UNRTDG. |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | There is only information on an autoignition temperature of below 225 deg C (ICSC (2000)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Organic substances containing no oxygen, fluorine or chlorine |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to low-temperature-boiling liquids are not available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 |
P301+P312
P362+P364 P264 P270 P330 P501 |
Based on reports of LD50 values of 1,500 mg/kg (SIDS (2012), DFGOT vol. 21 (2005), PATTY (5th, 2001)) and 1,800 mg/kg (DFGOT vol. 21 (2005), PATTY (5th, 2001)) for rats, it was classified in Category 4. |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on reports of LD50 values of >2,000 mg/kg for rats (SIDS (2012)) and >34,600 mg/kg for rabbits (DFGOT vol. 21 (2005), PATTY (5th, 2001)), it was classified as "Not classified." |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Category 4 |
Warning |
H332 |
P304+P340
P261 P271 P312 |
Based on reports of LC50 values (4 hours) of 4,020 ppm (SIDS (2012), DFGOT vol. 21 (2005), ACGIH (7th, 2001), PATTY (5th, 2001)) and 6,060 ppm (SIDS (2012), DFGOT vol. 21 (2005)) for rats, it was classified in Category 4. Besides, since the LC50 values were lower than 90% of the saturated vapor concentration (39,487 ppm), the reference value in units of ppm was applied as a vapour without a mist. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | In skin irritation tests with rabbits, there are reports that after application of 0.5 mL of the undiluted liquid of this substance for 4 hours, no skin reaction occurred (SIDS (2012)), that it was not irritating (PATTY (5th, 2001)), and that it was slightly irritating (PATTY (5th, 2001)). From the above results, it was classified as "Not classified" (Category 3 in UN GHS classification). The category was changed with the revised GHS classification guidance for the Japanese Government. |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 |
P305+P351+P338
P337+P313 P264 P280 |
In eye irritation tests with rabbits, there are reports that mild to moderate irritation of the eyes was observed (ACGIH (7th, 2001)), and that mild to moderate conjunctivitis was observed (PATTY (5th, 2001)). As above, based on a description of "moderate irritation," it was classified in Category 2A. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, although there is a description that it showed no sensitization to guinea pigs (PATTY (5th, 2001), DFGOT vol. 21 (2005)), details were unknown, therefore, they were judged to be insufficient data for classification. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There was no in vivo data. As for in vitro, it was all negative in bacterial reverse mutation tests, a mouse lymphoma test and a sister chromatid exchange test with cultured mammalian cells (SIDS (2012), DFGOT vol. 21 (2005), PATTY (5th, 2001)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - |
In teratogenicity tests with rats through the inhalation route, neither fetal toxicity nor embryotoxicity was observed at doses where maternal toxicities were observed. However, in teratogenicity tests with mice through the inhalation route, death of fetuses and embryos was observed at doses where severe maternal toxicities (death in 8/25 animals) were observed (SIDS (2012), DFGOT vol. 21 (2005), ACGIH (7th, 2001), PATTY (5th, 2001)). The data on mice which supported Category 2 in the previous classification was based on the same experiment as above. In DFGOT vol. 21 (2005), a newly added information source, general toxicities against parental animals were described in detail, and severe maternal toxicities were observed, therefore, they were not used for classification. As above, in teratogenicity tests, no clear effects were observed. However, because no information on fertility was obtained, it was classified as "Classification not possible." |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system), Category 3 (respiratory tract irritation, narcotic effects) |
Danger Warning |
H370
H335 H336 |
P308+P311
P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
This substance was irritating to the respiratory tract (SIDS (2012), ACGIH (7th, 2001)). In humans, in multiple accidental cases, malaise, nausea, headache, vomiting, drowsiness, weakness, coma, muscular weakness, central nervous system suppression, increased rate of breathing, dizziness and mydriasis were reported (ACGIH (7th, 2001)). As for experimental animals, labored breathing, reduced activity, prostration and tremors were observed at 3,870-9,810 ppm (14.9-37.7 mg/L) by 4-hour inhalation exposure of rats. Central nervous system suppression, muscle cramps, uncoordinated movement, cyanosis were observed with 4-hour inhalation exposure of mice at 2,500 ppm (9.6 mg/L). There was a report of restlessness, sedation and incoordination by an oral dose at 1,093-3,344 mg/kg in rats (SIDS (2012), ACGIH (7th, 2001), DFGOT vol. 21 (2005), PATTY (5th, 2001), HSDB (Access on August 2014)). Effects on the central nervous system in experimental animals were observed at concentrations within the guidance value range of Category 1. From the above, it was classified in Category 1 (central nervous system), Category 3 (respiratory tract irritation, narcotic effects). Besides, because "hemolytic anemia in an oral administration test with chickens in PATTY (4th, 1994)" described in the previous classification could not be confirmed, it was not adopted. |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | There were no hazardous data on humans from repeated exposure. As for experimental animals, in a test in which rats were exposed to the vapour of this substance by inhalation for 13 weeks, increased lung weight (male), increased alveolar macrophages (male and female), and changes in hemal parameters such as decreased red blood cells (female) were observed at the concentration range (0.26-0.55 mg/L/6 hours) corresponding to Category 2. However, it is described that the changes in the hematological test values were not of toxicological significance because of their being within the range of historical control values (SIDS (2012)). In addition, since pulmonary findings included no tissue injuries and no clear organic changes were observed overall in the respiratory tract tissues including the lungs, it was considered that the respiratory organs were out of the target organs. Therefore, from this test, it was not possible to identify the target organs to use for classification. On the other hand, there were no available data through the oral route (SIDS (2012)). Thus, classification was not possible due to lack of data. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Not classified |
- |
- | - | It was classified as "Not classified" from 96-hour EC50 = 1068300 ug/L for algae (Pseudokirchneriella subcapitata) and 96-hour LC50 = 1100000 ug/L for fish (Ictalurus punctatus) (both AQUIRE, 2015). |
11 | Hazardous to the aquatic environment (Long-term) | Not classified |
- |
- | - | Reliable chronic toxicity data were not obtained. It was classified as "Not classified" because it is not water-insoluble (water solubility = 597 mg/L, PHYSPROP Database, 2009) and was classified as "Not classified" in acute toxicity. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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