Item | Information |
---|---|
CAS RN | 77-47-4 |
Chemical Name | Hexachlorocyclopentadiene |
Substance ID | H26-B-086, R-036 |
Classification year (FY) | FY2014 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Not classified |
- |
- | - | It is not combustible (ICSC (2005)). |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | There is a chemical group associated with explosive properties (2 conjugated unsaturated bonds) present in the molecule, but the classification is not possible due to no data. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is not combustible (ICSC (2005)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (ICSC (2005)). |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. Besides, there is information that it corrodes various metals in presence of moisture (HSDB (Access on August 2014)). |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 |
P301+P312
P362+P364 P264 P270 P330 P501 |
There were reports of 11 data items of LD50 values of > 50 mg/kg (EU-RAR (2007)), 315 mg/kg (female), 425 mg/kg (male) (EU-RAR (2007), EHC 120 (1991)), 471 mg/kg (ATSDR (1999)), 505 mg/kg (male), 690 mg/kg (female) (EU-RAR (2007), IRIS TR (2001), EHC 120 (1991)), 584 mg/kg (male, female) (EU-RAR (2007), IRIS TR (2001), ATSDR (1999)), 630 mg/kg (ATSDR (1999)), 651 mg/kg (male, female) (EU-RAR (2007), EHC 120 (1991)), 926 mg/kg (male, female) (EHC 120 (1991)), and 1,400 mg/kg (male, female) (EU-RAR (2007)) for rats. It was classified in Category 4 to which the larger number of values (10 data) corresponded. |
1 | Acute toxicity (Dermal) | Category 3 |
Danger |
H311 |
P302+P352
P280 P312 P321 P361 P364 P405 P501 |
There are reports of 5 data items of LD50 values of < 200 mg/kg (male), 340 mg/kg (female) (EU-RAR (2007), EHC 120 (1991)), < 200 mg/kg (EU-RAR (2007)) and 780 mg/kg (EU-RAR (2007), EHC 120 (1991)) for rabbits, and LD50 values of 2,000-3,200 mg/kg (EU-RAR (2007)) for rats. It was classified in Category 3 to which the larger number of values (2 data items) corresponded according to the GHS classification guidance for the Japanese government. Besides, the category could not be specified by two reports with the minimum LD50 value, and the remaining one case corresponded to "Not classified" (Category 5 in UN GHS classification). A new information source (EU-RAR (2007)) was added, and the category was revised. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Category 1 |
Danger |
H330 |
P304+P340
P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Based on reports of LC50 values of 1.6 ppm (male), 3.5 ppm (female) (EU-RAR (2007), ATSDR (1999), EHC 120 (1991)), 3.7 ppm, 3.0 ppm (EU-RAR (2007)), 3.44 ppm, 1.6 ppm (male), and 3.9 ppm (female) (IRIS TR (2001)) for rats, it was classified in Category 1. Besides, since the LC50 value was lower than 90% of the saturated vapor concentration (78.9 ppm), the reference value in units of ppm was applied as a vapour without a mist. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Although there was a report of an LC50 value of < 2 mg/L for rats (EU-RAR (2007)), the category could not be specified only with this data. Besides, there is a description that the test was conducted with the mist and the aerosol, and the LC50 value was higher than the saturated vapor concentration (0.88 mg/L), therefore, the reference values as a mist were applied. |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 |
P301+P330+P331
P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
In a skin irritation test with rabbits, it was found corrosive in tests in which the undiluted liquid or a 10% aqueous solution of this substance was applied (EU-RAR (2007)). In addition, there are reports that it was also found corrosive in a test in which 40-90% aqueous solutions of this substance were applied to guinea pigs (EU-RAR (2007)) and that there was moderate to severe primary irritation on rabbit skin (EHC 120 (1991)). In humans, there is a report that it was irritating to the skin (IRIS (2001), EU-RAR (2007)). From the above, based on the "corrosive" results in rabbits, it was classified in Category 1. Besides, this substance was classified in "C; R34" in the EU DSD classification, in "Skin Corr. 1B H314" in the EU CLP classification. Information was added, and the category was changed. |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
There is a report that in an eye irritation test in which 0.1 mL of this substance (unknown concentration) was applied to rabbits, necrosis and blanching were observed and severe irritation was observed (EU-RAR (2007), EHC 120 (1991), ATSDR (1999)). In addition, this substance was classified in Category 1 in the classification for skin corrosion/irritation. From the above results, it was classified in Category 1. Based on additional information in EU-RAR (2007), and Category 1 for skin irritation, the category was changed. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Category 1 |
Warning |
H317 |
P302+P352
P333+P313 P362+P364 P261 P272 P280 P321 P501 |
In a skin sensitization test (OECD TG 406) with guinea pigs, the positive rate was 100%, and it was concluded that it was a skin sensitizer (EU-RAR (2007)). In addition, there is a report that in another sensitization test with guinea pigs, sensitization reaction was observed in all treated animals (EHC 120 (1991), EU-RAR (2007)). From the above results, it was classified in Category 1. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a mouse dominant lethal test and a micronucleus test with mouse peripheral blood erythrocytes (EU-RAR (2007), ATSDR (1999), NTP TR437 (1994), EHC 192 (1997), IUCLID (2000), NTP DB (Access on September 2014)). As for in vitro, it was negative in bacterial reverse mutation tests, mammalian cell gene mutation tests, and an unscheduled DNA synthesis test with rat primary cultured hepatocytes, and it was positive in a chromosomal aberration test and a sister chromatid exchange test with cultured mammalian cells (EU-RAR (2007), ACGIH (7th, 2001), NTP DB (Access on September 2014), IUCLID (2000)). |
6 | Carcinogenicity | Not classified |
- |
- | - |
It was classified in A4 by ACGIH (7th, 2001) and as E in 1986 and as NL in 1996 by EPA (IRIS (2001)). In addition, it was evaluated in SIAP (2007) that there was no evidence for carcinogenicity since no carcinogenicity was observed in any of carcinogenicity tests with rats and mice by inhalation exposure for 2 years and so on. From the above, although it corresponds to "Classification not possible" based on the classification by ACGIH and to "Not classified" based on the classification by EPA, by combining with the evaluation that there was no evidence for carcinogenicity since no evidence of carcinogenicity was observed in rats and mice (SIAP (2007)), EPA classification was prioritized, therefore, it was classified as "Not classified." Besides, although it was classified as "Not classified" based on A4 by ACGIH, as E and NL by EPA in the previous classification, according to the revised GHS classification guidance for the Japanese government, it was changed to "Classification not possible" in the case of A4 by ACGIH. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - |
Classification not possible due to lack of data. There are reports that in teratogenicity tests with rats, mice and rabbits by the oral route (gavage), neither maternal toxicity nor developmental toxicity was observed in rats and mice, and no developmental toxicity was observed even at doses where maternal toxicities were observed in rabbits (EU-RAR (2007), IRIS (2001), ATSDR (1999), NTP TR437 (1994), EHC 120 (1991)). Although it was classified as "Not classified" only based on the information from teratogenicity tests in the previous classification, since there was inadequate information on fertility, it was classified as "Classification not possible." |
8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory organs, liver, kidney), Category 3 (narcotic effects) |
Danger Warning |
H370
H336 |
P308+P311
P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
This substance was irritating to the respiratory tract (ACGIH (7th, 2001), ATSDR (1999), EHC 192 (1997), IRIS Tox. Review (2001), HSDB (Access on August 2014)). Although multiple cases were reported in humans, no data were available for classification. As for experimental animals, by the inhalation exposure with rats, pulmonary abnormalities (red focal or diffuse consolidation), pulmonary hemorrhage at or above 1.4 ppm (0.016 mg/L), infiltration of neutrophils, erythrocytes and fibrin in the necrotic tissue of the bronchial tubes, obliterative bronchitis, bronchiolitis, and connective tissue proliferations at 0.15-78.6 ppm (0.002-0.88 mg/L) were observed, and hyperemia and edema of the lungs were observed at 0.3-66 ppm (0.003-0.74 mg/L) in rats, mice, rabbits and guinea pigs. By oral administration, diarrhea, piloerection, hunched posture, abnormal gait, lethargy, decreased respiration, ptosis and pallor of the extremities were observed at 1,260-2,000 mg/kg in rats and 180-2,100 mg/kg in rabbits, hyperemia and edema of the lungs at 261-1,959 mg/kg in rats and rabbits, necrosis of the liver and kidney, degenerative changes of the liver, and degeneration of the kidney tubules at 401-5,719 mg/kg by dermal application to rabbits were observed. There are descriptions that the effects on the above experimental animals were observed not only in the dead animals but also in the surviving animals. And both effects on the respiratory organs by inhalation and oral exposures, and effects on the liver and kidney by dermal exposure were observed at concentrations within the guidance range of Category 1. In addition, it is described in EHC 192 (1997) and IRIS Tox. Review (2001) that irrespective of the administration route, acute exposure caused toxicities in the lung, liver, and kidney, and pathological changes were observed (EU-RAR (2007), ATSDR (1999), EHC 192 (1997), IRIS TR (2001)). From the above, it was classified in Category 1 (respiratory organs, liver, kidney), category 3 (narcotic effects). Although the liver and kidney were specified to Category 2 in the previous classification, since effects on the liver and kidneys were also observed at concentrations corresponding to Category 1, the category was changed. |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs), Category 2 (kidney) |
Danger Warning |
H372
H373 |
P260
P264 P270 P314 P501 |
Symptoms of the respiratory organs (cough, symptoms of throat irritation, chest discomfort, difficulty in breathing) in 39 of 145 workers exposed to this substance for 3-15 days at a wastewater treatment plant, and headaches (regarded as a secondary effect by stimulation to such as the respiratory organs) were observed in 22 workers. In addition, although no changes in blood counts were observed in a hematological test, urine samples taken from 6 of the 41 workers were positive for proteinuria (ATSDR (1999), IRIS TR (2001)). As for experimental animals, in NTP studies in which rats and mice were exposed by inhalation for 13 weeks or 2 years, and in a study in which rats were exposed by inhalation for 30 weeks, symptoms of the central nervous system (hypoactivity, lethargy), and the respiratory organs' damage (squamous metaplasia of the nasal cavity or larynx, extensive chronic inflammation, necrotic changes or brown pigmentation from the nasal cavity to the lungs (2-year inhalation exposure studies)) were observed within the concentration range of Category 1 (0.00011-0.0063 mg/L/6 hours) in any studies (EU-RAR (2007), ATSDR (1999), IRIS Tox. Review (2001)). Among these studies, there is a description that in 30-week inhalation exposure studies with rats, effects on the hemal system (increases in erythrocyte counts, hemoglobin concentration, hematocrit value and neutrophil ratio, etc. (males only)), and degenerative changes in the liver and kidneys were observed within the concentration range of Category 1 (EU-RAR (2007), ATSDR (1999), IRIS TR (2001)). However, the results from the other inhalation studies showed that effects were limited to the local areas of the respiratory organs. By the oral route, in studies in which this substance was administered by gavage to rats or mice for 13 weeks, nephropathy (proximal tubular dilation, cytoplasmic vacuolization or cytomegaly of the tubular epithelial cells, karyomegaly or anisokaryosis) was observed in both rats and mice within the concentration range of Category 2 (38-75 mg/kg/day). In addition, from lower doses, proliferative and inflammatory changes considered to be due to irritation of the forestomach were observed in both rats and mice (EU-RAR (2007), ATSDR (1999), IRIS TR (2001)). From the above, based on the findings in humans and experimental animals, it was classified in Category 1 (respiratory organs), Category 2 (kidney). |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 |
Warning |
H400 |
P273
P391 P501 |
It was classified in Category 1 from 96-hour LC50 = 7 microg/L for crustacea (Mysidopsis bahia) and 96-hour LC50 = 7 microg/L for fish (Pimephales promelas) (both EU-RAR, 2007, EHC 120, 1991). |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 |
Warning |
H410 |
P273
P391 P501 |
If chronic toxicity data are used, not rapidly degradable (BIOWIN), then it is classified in Category 1 from 28-day NOEC = 0.3 microg/L for crustacea (Mysidopsis bahia) (EU-RAR, 2007). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to being not rapidly degradable (BIOWIN), and 96-hour ErC50 = 190 microg/L for algae (Pseudokirchneriella subcapitata) (EU-RAR, 2007). From the above results, it was classified in Category 1. |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
|