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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	7775-27-1
Chemical Name	Disodium peroxydisulfate / Sodium peroxodisulfate
Substance ID	H26-B-089, R-037
Classification year (FY)	FY2014
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not classified	- -	-	-	There is a chemical group associated with explosive properties (neighboring oxygen atoms) present in the molecule. However, because it is classified in Division 5.1, PG III (UN1505) in UNRTDG, it was classified as "Not classified."
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition).
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition).
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition).
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition).
7	Flammable solids	Not classified	- -	-	-	It is not combustible (ICSC (2002)).
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	It was classified in oxidizing solids.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition).
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (ICSC (2002)).
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (ICSC (2002)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition).
14	Oxidizing solids	Category 3	Warning	H272	P370+P378 P210 P220 P221 P280 P501	It is classified in Division 5.1, PG III (UN1505) in UNRTDG.
15	Organic peroxides	Not applicable	- -	-	-	It is an inorganic compound.
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P362+P364 P264 P270 P330 P501	Based on reports of LD50 values of 895 mg/kg (male), 920 mg/kg (female), and 930 mg/kg (male) for rats (SIDS (2006), NICNAS (2001)), it was classified in Category 4.
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on a report of an LD50 value of >10,000 mg/kg for rabbits (SIDS (2006), NICNAS (2001)), it was classified as "Not classified."
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	Based on reports of LC50 values (4 hours) of >5.1 mg/L (SIDS (2006), NICNAS (2001)) and >21.6 mg/L (NICNAS (2001)) for rats, it was classified as "Not classified." Besides, the reference values for the dust were used based on the fact that this substance is a solid, there were no vapour pressure data and a description that the test was conducted with the dust.
2	Skin corrosion/irritation	Not classified	- -	-	-	In a skin irritation test in which this substance was applied to rabbits for 4 hours, the average scores for erythema and edema were 0, and it was judged to be not irritating (SIDS (2006)). In addition, in other studies with rabbits, the results were also not irritating or very slightly irritating (SIDS (2006), NICNAS (2001)). From the above results, by deleting the information sources in List 3, and adding the ones in List 1, the category was changed according to the revision of the GHS classification guidance for the Japanese Government.
3	Serious eye damage/eye irritation	Not classified	- -	-	-	In an eye irritation test with rabbits, the average scores for iritis, keratitis and conjunctivitis were all 0, and it was judged as not irritating (SIDS (2006)). In addition, although there is a description that in another test with rabbits, slight conjunctivitis was observed 48 hours after application (NICNAS (2001)), it was judged as not irritating in IUCLID (2000) which was a reference source of this description. From the above results, it was classified as "Not classified."
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	There are case reports that asthma symptoms were induced by inhalation exposure in humans (SIDS (2006), NICNAS (2001)). Since it was concluded in SIDS (2006) and NICNAS (2001) that this substance was positive in respiratory sensitization, it was classified in Category 1.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	There are two sensitization tests with guinea pigs (OECD TG 406, GLP-compliant). In one study, only slight erythema was observed (1/20 animals in the treatment group, 3/20 animals in the control group), therefore, it was judged as non-sensitizing (SIDS (2006)). In the other test, after induction, positive results were obtained for the challenge by intradermal injection, and negative results were obtained for the challenge by epidermal application (SIDS (2006), NICNAS (2001)). In humans, there are both results in patch tests indicating non-sensitizing (SIDS (2006)) and sensitizing (NICNAS (2001)). From these reports, it was determined in SIDS (2006) and NICNAS (2001) that this substance was a sensitizer. From the above results, although there were both negative and positive results, the positive results were obtained in humans and animals, and it was also concluded that it is sensitizing in assessment reports in other countries. Therefore, it was classified in Category 1.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a micronucleus test with mice and an unscheduled DNA synthesis test with rats (IUCLID (2000), NICNAS (2001)). As for in vitro, it was negative in a bacterial reverse mutation test, mammalian cell chromosome aberration test, and an unscheduled DNA synthesis test with cultured hepatocytes of rats (SIDS (2006), IUCLID (2000), NICNAS (2001)).
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 2 (systemic toxicity), Category 3 (respiratory tract irritation)	Warning	H371 H335	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	This substance was irritating to the respiratory tract. There were multiple cases in humans, but no data were available for classification. As for experimental animals, dyspnea, respiratory distress, and nasal discharge by inhalation exposure with rats, and nasal discharge, irregular breathing, sedation, ataxia, dyspnea, diarrhoea, muscular hypotonia and mydriasis by oral administration to rats were reported (SIDS (2006), ACGIH (7th, 2001), NICNAS (2001)). Besides, the findings by oral administration to rats were observed within the concentration range corresponding to Category 2. Based on these findings, it was considered to be irritating to the respiratory tract by inhalation, and by the oral route, effects on multiple organs were observed, however, effects on specific organs were not confirmed. From the above, it was classified in Category 2 (systemic toxicity), in addition, Category 3 (respiratory tract irritation).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	There were no adverse findings by repeated exposure to this substance with humans. As for experimental animals, in a study in which rats were administered by feeding for 90 days, no toxic findings were observed within or lower than the dose range for Category 2 (1,000 ppm: equivalent to 100 mg/kg/day), and even at a dose exceeding Category 2 (3,000 ppm: equivalent to 225 mg/kg/day), only changes in the gastrointestinal tract epithelial lining (necrosis, atrophy) considered to be due to irritation were observed (SIDS (2006), ACGIH (2001), NICNAS (2001)). Therefore, although it was considered to be equivalent to "Not classified" by the oral route, there was no toxic information in other routes, and it was classified as "Classification not possible" due to lack of data. Besides, in the previous classification, it was classified as "Not classified" only by the oral route information.
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Not classified	- -	-	-	It was classified as "Not classified" from 72-hour ErC50 >1000 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)), 48-hour EC50 = 133 mg/L for crustacea (Daphnia magna) (SIDS, 2005), and 96-hour LC50 >100 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)).
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	If chronic toxicity data are used, then it is classified as "Not classified" from 72-hour NOEC = 3.2 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)) although environmental dynamics of the inorganic compound are unknown. If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" because it corresponds to "Not classified" in acute toxicity for fish and is not water-insoluble (water solubility = 549 g/L (NITE, 2014)). From the above results, it was classified as "Not classified."
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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