GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 382-21-8
Chemical Name 1,1,3,3,3-Pentafluoro-2-(trifluoromethyl)-1-propene (PFIB)
Substance ID H26-B-093, -
Classification year (FY) FY2014
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - Gas (GHS definition)
2 Flammable gases (including chemically unstable gases) Classification not possible
-
-
- - No data available.
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Classification not possible
-
-
- - No data available.
5 Gases under pressure Classification not possible
-
-
- - No data available.
6 Flammable liquids Not applicable
-
-
- - Gas (GHS definition)
7 Flammable solids Not applicable
-
-
- - Gas (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - Gas (GHS definition)
9 Pyrophoric liquids Not applicable
-
-
- - Gas (GHS definition)
10 Pyrophoric solids Not applicable
-
-
- - Gas (GHS definition)
11 Self-heating substances and mixtures Not applicable
-
-
- - Gas (GHS definition)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - Gas (GHS definition)
13 Oxidizing liquids Not applicable
-
-
- - Gas (GHS definition)
14 Oxidizing solids Not applicable
-
-
- - Gas (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Gas (GHS definition)
16 Corrosive to metals Classification not possible
-
-
- - Test methods applicable to gas substances are not available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not applicable
-
-
- - Gas (GHS definition)
1 Acute toxicity (Dermal) Not applicable
-
-
- - Gas (GHS definition)
1 Acute toxicity (Inhalation: Gases) Category 1


Danger
H330 P304+P340
P403+P233
P260
P271
P284
P310
P320
P405
P501
Based on a report of an LC50 value (2 hours) of 1.05 ppm for rats (converted 4-hour equivalent value: 0.742 ppm) (ACGIH (7th, 2001)), it was classified in Category 1.
1 Acute toxicity (Inhalation: Vapours) Not applicable
-
-
- - Gas (GHS definition)
1 Acute toxicity (Inhalation: Dusts and mists) Not applicable
-
-
- - Gas (GHS definition)
2 Skin corrosion/irritation Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, although there is a description that this substance was irritating to the skin (HSDB (Access on September 2014)), it was judged to be of inadequate data to use for classification since details were unknown.
3 Serious eye damage/eye irritation Classification not possible
-
-
- - Classification not possible due to lack of data. Besides, although there is a description that this substance was irritating to the eyes and mucous membrane (HSDB (Access on September 2014)), it was judged to be of inadequate data to use for classification since details were unknown.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
6 Carcinogenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory organs)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
This substance was irritating to the respiratory tract (ACGIH (7th, 2001)). In addition, it induced pulmonary edema (ACGIH (7th, 2001), HSDB (Access on September 2014)). In humans, it was highly toxic by the inhalation route, and severe symptoms of pulmonary edema with chest pain, coughing, sputum, bluish discoloration of the skin, wheezing and difficulty in breathing were caused by exposure. Pulmonary edema had a delayed onset of several hours and then became rapidly worse, resulting in death (HSDB (Access on September 2014)).
Also, in experimental animals, it acted like in humans and caused pulmonary edema. By a 4-hour exposure of rats, increases in serum AST and ALT activities, changes in conditioned reflexes (details unknown) and pulmonary edema at 0.24 ppm, dyspnea, hyperpnea and pulmonary hyperemia at 0.25 ppm were observed. And an increase in respiration rates was observed at 0.3 ppm (ACGIH (7th, 2001)).
From the above, the target organ was determined to be the lungs, and in experimental animal tests, symptoms were observed at doses within the guidance value range of Category 1, therefore, it was classified in Category 1 (respiratory organs).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory organs)


Danger
H372 P260
P264
P270
P314
P501
In ACGIH (7th, 2001), in two tests in which rats were exposed by inhalation to this substance (the gas) at a concentration of 0.1 ppm for 10 days (6 hours/day, 5 days/week), while there is a description that exposure caused mild respiratory impairment and restlessness, and in some animals, cyanosis and moist rales were observed. No pathological abnormalities were observed at necropsy in any tests. Other than these, there were no known hazards by repeated exposure to this substance. However, this substance caused severe acute toxicity by the inhalation route (HSDB (Access on September 2014)). In addition, although the details were unknown, there is a description that this substance showed similar effects in animals and humans, and death cases occurred due to acute pulmonary effects including pulmonary edema (ACGIH (7th, 2001)), therefore, in repeated exposure, "respiratory organs" were considered to be the target organ. The introductory 10-day inhalation exposure test with rats corresponded to a 2-week exposure test. Considering that the minimum requirements for the administration duration (14 days (2 weeks) or more) were met as data available for classification, the converted value for the guidance value category was 0.015 ppm, and respiratory disorders were observed from the lower limit concentrations of Category 1, and it was well assumed that clear respiratory effects occurred at further higher concentrations within the range of Category 1 (<=50 ppm). Therefore, it was classified in Category 1 (respiratory organs).
Besides, although it was classified in Category 1 (central nervous system) in the previous classification based on the results of a 19-week intermittent inhalation exposure test with rats listed in the information source in List 3 (RTECS), in this investigation, this test could not be found among information sources in List 1 (ACGIH), List 2 (HSDB), and List 3 (GESTIS, ICSC).
10 Aspiration hazard Not applicable
-
-
- - Gas (GHS definition)

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) -
-
-
- - -
11 Hazardous to the aquatic environment (Long-term) -
-
-
- - -
12 Hazardous to the ozone layer -
-
-
- - -


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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