Item | Information |
---|---|
CAS RN | 78-78-4 |
Chemical Name | 2-Methylbutane |
Substance ID | H26-B-095, R-041 |
Classification year (FY) | FY2014 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Category 1 |
Danger |
H224 |
P303+P361+P353
P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
It was classified in Category 1 based on a flash point of < -51 deg C (closed cup) and a boiling point of 28 deg C (ICSC (1994)). Besides, it is classified in Class 3, PG I (UN1265) in UNRTDG. |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 420 deg C (ICSC (1994)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to gas substances are not available at a test temperature of 55 deg C. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, although there is a report of an LC50 value (4 hours) of >4,094 ppm for rats (SIDS (2010)), the category could not be specified only with this data. By adding a new information source (SIDS (2010)) and giving priority to the data in rats listed in List 1 according to the GHS Classification Guidance for the Japanese Government, it was classified as "Classification not possible." |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | There is a report that when this substance (0.1-0.3 mL) was applied semi-occlusively to humans (30 subjects) for 24 hours, the primary irritation score was 0.33 and no irritation was observed (SIDS (2010)). On the other hand, although no specific cases were reported, there is a description that it is irritating to the skin of humans (HSDB (Access on September 2014)). From the above results, it was classified as "Not classified" (Category 3 in UN GHS classification). By adding the specific report on humans, the category was changed. |
3 | Serious eye damage/eye irritation | Category 2 |
Warning |
H319 |
P305+P351+P338
P337+P313 P264 P280 |
Although no specific cases were reported, based on a description that this substance is irritating to the eyes (HSDB (Access on September 2014)), it was classified in Category 2. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Not classified |
- |
- | - | There is a description that in a skin sensitization test with guinea pigs (20 animals/group) (OECD TG 406, GLP-compliant), no reaction after the challenge was observed, and it was not sensitizing (SIDS (2010)). From the above result, it was classified as "Not classified." By adding information in List 1, the category was revised. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | As for in vivo, it was negative in a dominant lethal test with mice and a micronucleus test with rat bone marrow cells (ACGIH (7th, 2014)). As for in vitro, it was negative in bacterial reverse mutation tests and a chromosomal aberration test with cultured mammalian cells (SIDS (2010), ACGIH (7th, 2014), NTP DB (Access on October 2014)). From the above, it was classified as "Classification not possible." |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 3 (respiratory tract irritation, narcotic effects) |
Warning |
H335
H336 |
P304+P340
P403+P233 P261 P271 P312 P405 P501 |
In humans, there are reports of respiratory tract irritation and narcotic effects (ACGIH (7th, 2014), HSDB (Access on September 2014)), of cough, dizziness, drowsiness, headache, shortness of breath and sore throat by inhalation, of abdominal pain, nausea and vomiting by oral ingestion, and of unconsciousness or death although exposure route was unknown (ACGIH (7th, 2014), PATTY (5th, 2001), HSDB (Access on September 2014)). As for experimental animals, there is a report that a narcotic effect appeared after inhalation exposure (PATTY (5th, 2001)). From the above, it was classified in Category 3 (respiratory tract irritation, narcotic effects). |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There were no findings by repeated exposure with humans. As for experimental animals, although there were results in repeated inhalation exposure tests which were conducted by combined exposure to other hydrocarbon compounds, there was no toxicity information by exposure to only this substance through the inhalation route (SIDS (2010)). In addition, when male rats were administered by gavage for 28 days, although no specific target organ toxicity was detected, it was a test with limited endpoints (focused to renal toxicity) (SIDS (2010), IUCLID (2000)), and it cannot be used for classification. |
10 | Aspiration hazard | Category 1 |
Danger |
H304 |
P301+P310
P331 P405 P501 |
Since it is a hydrocarbon, and the kinematic viscosity was 0.345 mm2/sec. (20 deg C, calculated value by CERI), it was classified in Category 1. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 2 |
- |
H401 |
P273
P501 |
It was classified in Category 2 from 48-hour EC50 = 2.3 mg/L for crustacea (Daphnia magna) (SIDS, 2010). |
11 | Hazardous to the aquatic environment (Long-term) | Not classified |
- |
- | - | Reliable chronic toxicity data were not obtained. Although it was classified in Category 2 in acute toxicity, it was classified as "Not classified" due to rapid degradability (a 28-day degradation rate in a degradation test by OECD TG301F = 71.4% (SIDS, 2010)), and a low bioconcentration estimate (LogPow = 2.72 (PHYSPROP Database, 2009)). |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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