GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 110-12-3
Chemical Name 5-Methyl-2-hexanone
Substance ID H26-B-102, -
Classification year (FY) FY2014
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Category 3


Warning
H226 P303+P361+P353
P370+P378
P403+P235
P210
P233
P240
P241
P242
P243
P280
P501
It was classified in Category 3 based on a flash point of 36 deg C (closed cup) (ICSC (1998)).
Besides, it is classified in Class 3, PG III (UN2302) in UNRTDG.
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 191 deg C (ICSC (1998)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- - No data available.

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Not classified
-
-
- - Based on reports of LD50 values of 2,542 mg/kg, 3,200 mg/kg (PATTY (6th, 2012)) and 4,190 mg/kg (ACGIH (7th, 2013)) for rats, it was classified as "Not classified" (Category 5 in UN GHS classification).
1 Acute toxicity (Dermal) Not classified
-
-
- - Based on reports of an LD50 value of 8,880 mg/kg for rabbits (ACGIH (7th, 2013), PATTY (6th, 2012)), it was classified as "Not classified."
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Category 4


Warning
H332 P304+P340
P261
P271
P312
Based on a report of an LC50 value (6 hours) of 3,813 ppm (converted 4-hour equivalent value: 4,670 ppm) for rats (PATTY (6th, 2012)), it was classified in Category 4. Besides, since the LC50 value was lower than 90% of the saturated vapor concentration (5,923 ppm), the reference value in units of ppm was applied as a vapour without a mist.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible
-
-
- - Classification not possible due to lack of data.
2 Skin corrosion/irritation Classification not possible
-
-
- - There are descriptions that slight irritation was observed after application of this substance (undiluted) to guinea pigs for 24 hours (PATTY (6th, 2012)), and that erythema and necrosis were observed after application of this substance (20 mL/kg) to rabbits for 24 hours (ACGIH (7th, 2014)). Since the above results were data of the 24-hour application, they were judged to be insufficient data to determine the category, and it was classified as "Classification not possible."
3 Serious eye damage/eye irritation Category 2B
-
Warning
H320 P305+P351+P338
P337+P313
P264
Based on a description that slight irritation was observed in an eye irritation test with rabbits (ACGIH (7th, 2001)), it was classified in Category 2B.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Classification not possible
-
-
- - Classification not possible due to lack of data. Although there is a description that slight skin sensitization was observed in 1 of 5 animals (20%) in a skin sensitization test with guinea pigs (complete Freund's adjuvant test) (PATTY (6th, 2012)), the number of animals was small, and details of the result, etc. were unknown, therefore, they were judged to be insufficient data for classification.
5 Germ cell mutagenicity Classification not possible
-
-
- - Classification not possible due to lack of data. There are no in vivo data. As for in vitro, it was negative in a bacterial reverse mutation test (ACGIH (7th, 2013)).
6 Carcinogenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Category 3 (respiratory tract irritation, narcotic effects)


Warning
H335
H336
P304+P340
P403+P233
P261
P271
P312
P405
P501
This substance is irritating to the respiratory tract (ACGIH (7th, 2001), PATTY (6th, 2012), HSDB (Access on September 2014)). There are no human data, however, as for experimental animals, a decreased response to noise at 1,603 ppm (7.49 mg/L), and a decreased respiratory rate and narcosis at 3,207 ppm (14.98 mg/L) by an inhalation exposure with rats (ACGIH (2013), HSDB (Access on September 2014)) were reported. From the above, it was classified in Category 3 (respiratory tract irritation, narcotic effects).
9 Specific target organ toxicity - Repeated exposure Category 2 (central nervous system, respiratory organs, kidney)


Warning
H373 P260
P314
P501
There are no adverse findings by exposure to this substance in humans. However, it is reported that irritation of the mucous membranes, and symptoms in the central nervous system and gastrointestine were observed in occupational exposure to methyl isobutyl ketone (CAS RN: 108-10-1), a substance with a related chemical structure (ACGIH (7th, 2013)).
On the other hand, as for experimental animals, there is a description that in a study in which rats were exposed by inhalation to the vapour of this substance for 2 or 13 weeks, at a concentration of 1,000 ppm (4.66 mg/L: 1 ppm=4.66 mg/m3 (ACGIH (7th, 2013))), nasal and eye irritation, lethargy, decreased aural response, and effects on the kidney (increased weight, regeneration of the tubular epithelium, hyaline droplet formation) were observed (PATTY (6th, 2012), ACGIH (7th, 2013)), and in the 2-week inhalation test, effects on the nasal mucosa, central nervous system and kidney were observed within the range for Category 2 (converted guidance value: 0.62 mg/L/6 hours).
From the above, based on the findings in experimental animals, it was classified in Category 2 (central nervous system, respiratory organs, kidney). Besides, this time, based on the results of the above inhalation exposure tests with rats, which were evidence data for reviewing the TLV value in ACGIH (7th, 2013) after the previous classification, target organs were added. Therefore, the classification result was different from the previous one.
10 Aspiration hazard Classification not possible
-
-
- - It is a ketone composed of less than 13 carbon atoms, and a kinematic viscosity of 0.867 (20 deg C, calculated value by CERI). Since it corresponded to Category 2 in UN GHS classification, it was classified as "Classification not possible" according to the current GHS Classification Guidance for the Japanese Government.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) -
-
-
- - -
11 Hazardous to the aquatic environment (Long-term) -
-
-
- - -
12 Hazardous to the ozone layer -
-
-
- - -


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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