Item | Information |
---|---|
CAS RN | 68-11-1 |
Chemical Name | Mercaptoacetic acid |
Substance ID | H26-B-106, R-049 |
Classification year (FY) | FY2014 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Liquid (GHS definition) |
5 | Gases under pressure | Not applicable |
- |
- | - | Liquid (GHS definition) |
6 | Flammable liquids | Not classified |
- |
- | - | From information of a flash point: 126 deg C (open cup) (ICSC (1998)), it was judged that a flash point will be 93 deg C or higher as well in prescribed closed cup methods, and it was classified as "Not classified." |
7 | Flammable solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 350 deg C (ICSC (1998)). |
10 | Pyrophoric solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
13 | Oxidizing liquids | Not applicable |
- |
- | - | The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen. |
14 | Oxidizing solids | Not applicable |
- |
- | - | Liquid (GHS definition) |
15 | Organic peroxides | Not applicable |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. Besides, it is described that it attacks steel, stainless steel, and aluminum (ICSC (1998)). |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 |
P301+P310
P361+P364 P264 P270 P321 P330 P405 P501 |
There are 3 reports of LD50 values of <50 mg/kg (ACGIH (7th, 2001)), 73 mg/kg (SIDS (2010)) and 114-136 mg/kg (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)) for rats. It was classified in Category 3 to which the largest number of data corresponded. |
1 | Acute toxicity (Dermal) | Category 3 |
Danger |
H311 |
P302+P352
P280 P312 P321 P361 P364 P405 P501 |
Based on a report of an LD50 value of 848 mg/kg for rabbits (SIDS (2010), ACGIH (7th, 2001)), it was classified in Category 3. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Liquid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Since the data that were evidence for the previous classification were quoted from information sources in List 3, and the original report could not be confirmed, it was not adopted for classification. |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 4 |
Warning |
H332 |
P304+P340
P261 P271 P312 |
Based on reports of LC50 values (4 hours) (OECD TG 403) of 2.172 mg/L (male) and 1.098 mg/L (female) for rats (SIDS (2010)), it was classified in Category 4. Besides, since there is a description that the test was conducted with aerosols, and the LC50 value was higher than the saturated vapor concentration (0.595 mg/L), the reference value for a mist was applied. A new information source (SIDS (2010)) was added, and the category was revised. |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 |
P301+P330+P331
P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
Since necrosis was observed within 5 minutes after application of the undiluted liquid of this substance to the skin of rabbits, this substance was judged to be corrosive (SIDS (2010)). In humans, there are reports that by exposure to this substance at a high concentration, it caused a second-degree burn on the skin (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), and that ulcers and a permanent scar were observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). From the above results, it was classified in Category 1. Besides, this substance was classified as "R34" in the EU DSD classification, and as "Skin Corr. 1B H314" in the EU CLP classification. |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
There is a description that as a result of application of this substance to the eyes of rabbits, strong conjunctivitis and corneal opacity were observed, and no reversibility was observed within 14 days (ACGIH (7th, 2001)). In addition, this substance was classified in Category 1 for skin corrosion/irritation. From the above results, it was classified in Category 1. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Category 1 |
Warning |
H317 |
P302+P352
P333+P313 P362+P364 P261 P272 P280 P321 P501 |
There are multiple reports that positive reactions were observed in humans in patch tests with this substance (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). On the other hand, there is a report that it was negative in a skin sensitization test with guinea pigs (SIDS (2010)). Since there are multiple reports that it was positive in humans, it was classified in Category 1. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | As for in vivo, it was negative in a micronucleus test with mouse bone marrow cells (SIDS (2010)). As for in vitro, it was negative in bacterial reverse mutation tests and a chromosomal aberration test with cultured mammalian cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), SIDS (2010), NTP DB (Access on October 2014)). From the above, it was classified as "Classification not possible" according to the GHS Classification Guidance for the Japanese Government. |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system, respiratory organs, systemic toxicity) |
Danger |
H370 |
P308+P311
P260 P264 P270 P321 P405 P501 |
This substance is irritating to the respiratory tract (SIDS (2010)). In humans, there is a report of acute pulmonary edema, lung injury (hemorrhagic fibrous bronchitis), severe lactacidemia, renal failure, adult respiratory distress syndrome and multiple organ failure consisting of liver failure and rhabdomyolysis in an accidental case by an unknown route, and by the oral ingestion or dermal exposure, corrosion of the mucosa of the oral cavity, pharynx and esophagus with dysphagia, stomach pain with nausea and vomiting, gastric hemorrhage, tachycardia, shallow breathing, oliguria, death due to circulatory collapse, and death from suffocation due to glottis edema. In addition, ulceration of the mucosa at the contact site was reported (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). As for experimental animals, nasal irritation, respiratory distress, bradypnea, labored breathing, irregular breathing, mobility reduced, apathy, tremors, paralysis, prostration, reduced reflexes, eye closure, restlessness and posture squatted and pulmonary congestion in the dead animals from inhalation exposure in rats, dyspnea, piloerection, lethargy, ptosis, prostration and convulsions by oral administration to rats, and tremors and convulsions by dermal exposure to mice, were observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), SIDS (2010), ACGIH (7th, 2001)). These effects on the central nervous system and respiratory organs were observed at doses within the range corresponding to Category 1. From the above, it was classified in Category 1 (central nervous system, respiratory organs, systemic toxicity). |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (haemal system, liver, kidney) |
Warning |
H373 |
P260
P314 P501 |
There are no findings on effects by repeated exposure in humans. In tests with experimental animals, since this substance is corrosive, the test was conducted with the sodium salt of this substance (CAS RN: 367-51-1). As for in vivo, considering that this substance and its sodium salt show almost equivalent toxicity, classification was conducted based on test results using sodium salts. In a test in which the sodium salt of this substance was administered by gavage to rats for 13 weeks, effects on the blood system (a decrease of the total white blood cell number and lymphocytes, a slight increase in red blood cell number and hemoglobin concentrations, an extension of prothrombin times (PT), etc.), effects on the liver (increased weight, increases in serum AST, ALT and LDH, periportal hepatocellular microvacuolation, single cell necrosis), and effects on the kidney (increase of serum urea and creatinine, proximal tubule vacuolation) were observed at the highest dose of 60 mg/kg/day (corresponding to Category 2) (SIDS (2010)). Other than these, extramedullary hematopoiesis in the spleen and in the liver, cortical atrophy in the thymus, and decreased M/E ratio (myeloid/erythroid ratio) were observed (SIDS (2010)). However, these findings were considered to be related to effects on the blood. On the other hand, in tests in which the sodium salt of this substance was applied dermally to rats or mice for 13 weeks, there was no specific target organ other than local irritation effects on the skin of the application site observed in both species within and lower than the dose range for Category 2 (maximum dose: 180 mg/kg/day in rats, 360 mg/kg/day in mice) (SIDS (2010)), therefore, by the dermal route, it was considered to be roughly equivalent to "Not classified." From the above, it was classified in Category 2 (blood system, liver, kidney). Besides, SIDS (2010) which was issued after the previous classification was used, therefore, classification became possible in this classification. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 3 |
- |
H402 |
P273
P501 |
It was classified in Category 3 from 48-hour EC50 = 35.8 mg/L for crustacea (Daphnia magna) (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013), Initial Risk Assessment (NITE, CERI, NEDO, 2008)). |
11 | Hazardous to the aquatic environment (Long-term) | Not classified |
- |
- | - |
If chronic toxicity data are used, then it is classified as "Not classified" due to rapid degradability (a 28-day degradation rate: 67% (SIDS, 2010)), and 72-hour NOEC = 2.2 mg/L for algae (Pseudokirchneriella subcapitata) (Initial Risk Assessment (NITE, CERI, NEDO, 2008)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to rapid degradability (a 28-day degradation rate: 67% (SIDS, 2010)), and a low bioaccumulation estimate (log Kow = 0.09 (PHYSPROP Database, 2009)) despite 96-hour LC50 = 39.8 mg/L for fish (Oryzias latipes) (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013), Initial Risk Assessment (NITE, CERI, NEDO, 2008)). From the above results, it was classified as "Not classified." |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. |
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