GHS Classification Result

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GENERAL INFORMATION
Item Information
CAS RN 68-11-1
Chemical Name Mercaptoacetic acid
Substance ID H26-B-106, R-049
Classification year (FY) FY2014
Ministry who conducted the classification Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised Revised
Classification result in other fiscal year FY2006  
Download of Excel format Excel file

REFERENCE INFORMATION
Item Information
Guidance used for the classification (External link) GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link) UN GHS document
Definitions/Abbreviations (Excel file) Definitions/Abbreviations
Model Label by MHLW (External link) MHLW Website (in Japanese Only)
Model SDS by MHLW (External link) MHLW Website (in Japanese Only)
OECD/eChemPortal (External link) eChemPortal

PHYSICAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Explosives Not applicable
-
-
- - There are no chemical groups associated with explosive properties present in the molecule.
2 Flammable gases (including chemically unstable gases) Not applicable
-
-
- - Liquid (GHS definition)
3 Aerosols Not applicable
-
-
- - Not aerosol products.
4 Oxidizing gases Not applicable
-
-
- - Liquid (GHS definition)
5 Gases under pressure Not applicable
-
-
- - Liquid (GHS definition)
6 Flammable liquids Not classified
-
-
- - From information of a flash point: 126 deg C (open cup) (ICSC (1998)), it was judged that a flash point will be 93 deg C or higher as well in prescribed closed cup methods, and it was classified as "Not classified."
7 Flammable solids Not applicable
-
-
- - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not applicable
-
-
- - There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9 Pyrophoric liquids Not classified
-
-
- - It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 350 deg C (ICSC (1998)).
10 Pyrophoric solids Not applicable
-
-
- - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible
-
-
- - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable
-
-
- - The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable
-
-
- - The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14 Oxidizing solids Not applicable
-
-
- - Liquid (GHS definition)
15 Organic peroxides Not applicable
-
-
- - Organic compounds containing no bivalent -O-O- structure in the molecule
16 Corrosive to metals Classification not possible
-
-
- - No data available. Besides, it is described that it attacks steel, stainless steel, and aluminum (ICSC (1998)).

HEALTH HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
1 Acute toxicity (Oral) Category 3


Danger
H301 P301+P310
P361+P364
P264
P270
P321
P330
P405
P501
There are 3 reports of LD50 values of <50 mg/kg (ACGIH (7th, 2001)), 73 mg/kg (SIDS (2010)) and 114-136 mg/kg (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)) for rats. It was classified in Category 3 to which the largest number of data corresponded.
1 Acute toxicity (Dermal) Category 3


Danger
H311 P302+P352
P280
P312
P321
P361
P364
P405
P501
Based on a report of an LD50 value of 848 mg/kg for rabbits (SIDS (2010), ACGIH (7th, 2001)), it was classified in Category 3.
1 Acute toxicity (Inhalation: Gases) Not applicable
-
-
- - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible
-
-
- - Classification not possible due to lack of data. Since the data that were evidence for the previous classification were quoted from information sources in List 3, and the original report could not be confirmed, it was not adopted for classification.
1 Acute toxicity (Inhalation: Dusts and mists) Category 4


Warning
H332 P304+P340
P261
P271
P312
Based on reports of LC50 values (4 hours) (OECD TG 403) of 2.172 mg/L (male) and 1.098 mg/L (female) for rats (SIDS (2010)), it was classified in Category 4. Besides, since there is a description that the test was conducted with aerosols, and the LC50 value was higher than the saturated vapor concentration (0.595 mg/L), the reference value for a mist was applied. A new information source (SIDS (2010)) was added, and the category was revised.
2 Skin corrosion/irritation Category 1


Danger
H314 P301+P330+P331
P303+P361+P353
P305+P351+P338
P304+P340
P260
P264
P280
P310
P321
P363
P405
P501
Since necrosis was observed within 5 minutes after application of the undiluted liquid of this substance to the skin of rabbits, this substance was judged to be corrosive (SIDS (2010)). In humans, there are reports that by exposure to this substance at a high concentration, it caused a second-degree burn on the skin (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), and that ulcers and a permanent scar were observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). From the above results, it was classified in Category 1. Besides, this substance was classified as "R34" in the EU DSD classification, and as "Skin Corr. 1B H314" in the EU CLP classification.
3 Serious eye damage/eye irritation Category 1


Danger
H318 P305+P351+P338
P280
P310
There is a description that as a result of application of this substance to the eyes of rabbits, strong conjunctivitis and corneal opacity were observed, and no reversibility was observed within 14 days (ACGIH (7th, 2001)). In addition, this substance was classified in Category 1 for skin corrosion/irritation. From the above results, it was classified in Category 1.
4 Respiratory sensitization Classification not possible
-
-
- - Classification not possible due to lack of data.
4 Skin sensitization Category 1


Warning
H317 P302+P352
P333+P313
P362+P364
P261
P272
P280
P321
P501
There are multiple reports that positive reactions were observed in humans in patch tests with this substance (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). On the other hand, there is a report that it was negative in a skin sensitization test with guinea pigs (SIDS (2010)). Since there are multiple reports that it was positive in humans, it was classified in Category 1.
5 Germ cell mutagenicity Classification not possible
-
-
- - As for in vivo, it was negative in a micronucleus test with mouse bone marrow cells (SIDS (2010)). As for in vitro, it was negative in bacterial reverse mutation tests and a chromosomal aberration test with cultured mammalian cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), SIDS (2010), NTP DB (Access on October 2014)). From the above, it was classified as "Classification not possible" according to the GHS Classification Guidance for the Japanese Government.
6 Carcinogenicity Classification not possible
-
-
- - Classification not possible due to lack of data.
7 Reproductive toxicity Classification not possible
-
-
- - Classification not possible due to lack of data.
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, respiratory organs, systemic toxicity)


Danger
H370 P308+P311
P260
P264
P270
P321
P405
P501
This substance is irritating to the respiratory tract (SIDS (2010)). In humans, there is a report of acute pulmonary edema, lung injury (hemorrhagic fibrous bronchitis), severe lactacidemia, renal failure, adult respiratory distress syndrome and multiple organ failure consisting of liver failure and rhabdomyolysis in an accidental case by an unknown route, and by the oral ingestion or dermal exposure, corrosion of the mucosa of the oral cavity, pharynx and esophagus with dysphagia, stomach pain with nausea and vomiting, gastric hemorrhage, tachycardia, shallow breathing, oliguria, death due to circulatory collapse, and death from suffocation due to glottis edema. In addition, ulceration of the mucosa at the contact site was reported (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)).
As for experimental animals, nasal irritation, respiratory distress, bradypnea, labored breathing, irregular breathing, mobility reduced, apathy, tremors, paralysis, prostration, reduced reflexes, eye closure, restlessness and posture squatted and pulmonary congestion in the dead animals from inhalation exposure in rats, dyspnea, piloerection, lethargy, ptosis, prostration and convulsions by oral administration to rats, and tremors and convulsions by dermal exposure to mice, were observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), SIDS (2010), ACGIH (7th, 2001)). These effects on the central nervous system and respiratory organs were observed at doses within the range corresponding to Category 1.
From the above, it was classified in Category 1 (central nervous system, respiratory organs, systemic toxicity).
9 Specific target organ toxicity - Repeated exposure Category 2 (haemal system, liver, kidney)


Warning
H373 P260
P314
P501
There are no findings on effects by repeated exposure in humans. In tests with experimental animals, since this substance is corrosive, the test was conducted with the sodium salt of this substance (CAS RN: 367-51-1). As for in vivo, considering that this substance and its sodium salt show almost equivalent toxicity, classification was conducted based on test results using sodium salts.
In a test in which the sodium salt of this substance was administered by gavage to rats for 13 weeks, effects on the blood system (a decrease of the total white blood cell number and lymphocytes, a slight increase in red blood cell number and hemoglobin concentrations, an extension of prothrombin times (PT), etc.), effects on the liver (increased weight, increases in serum AST, ALT and LDH, periportal hepatocellular microvacuolation, single cell necrosis), and effects on the kidney (increase of serum urea and creatinine, proximal tubule vacuolation) were observed at the highest dose of 60 mg/kg/day (corresponding to Category 2) (SIDS (2010)). Other than these, extramedullary hematopoiesis in the spleen and in the liver, cortical atrophy in the thymus, and decreased M/E ratio (myeloid/erythroid ratio) were observed (SIDS (2010)). However, these findings were considered to be related to effects on the blood. On the other hand, in tests in which the sodium salt of this substance was applied dermally to rats or mice for 13 weeks, there was no specific target organ other than local irritation effects on the skin of the application site observed in both species within and lower than the dose range for Category 2 (maximum dose: 180 mg/kg/day in rats, 360 mg/kg/day in mice) (SIDS (2010)), therefore, by the dermal route, it was considered to be roughly equivalent to "Not classified."
From the above, it was classified in Category 2 (blood system, liver, kidney). Besides, SIDS (2010) which was issued after the previous classification was used, therefore, classification became possible in this classification.
10 Aspiration hazard Classification not possible
-
-
- - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Pictogram
Signal word
Hazard statement
(code)
Precautionary statement
(code)
Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 3
-
-
H402 P273
P501
It was classified in Category 3 from 48-hour EC50 = 35.8 mg/L for crustacea (Daphnia magna) (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013), Initial Risk Assessment (NITE, CERI, NEDO, 2008)).
11 Hazardous to the aquatic environment (Long-term) Not classified
-
-
- - If chronic toxicity data are used, then it is classified as "Not classified" due to rapid degradability (a 28-day degradation rate: 67% (SIDS, 2010)), and 72-hour NOEC = 2.2 mg/L for algae (Pseudokirchneriella subcapitata) (Initial Risk Assessment (NITE, CERI, NEDO, 2008)).
If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to rapid degradability (a 28-day degradation rate: 67% (SIDS, 2010)), and a low bioaccumulation estimate (log Kow = 0.09 (PHYSPROP Database, 2009)) despite 96-hour LC50 = 39.8 mg/L for fish (Oryzias latipes) (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013), Initial Risk Assessment (NITE, CERI, NEDO, 2008)).
From the above results, it was classified as "Not classified."
12 Hazardous to the ozone layer Classification not possible
-
-
- - This substance is not listed in the Annexes to the Montreal Protocol.


NOTE:
  • GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
  • Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
  • This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
  • Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
  • A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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