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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	141-79-7
Chemical Name	Mesityloxid (Mesityl oxide)
Substance ID	H26-B-112, R-053
Classification year (FY)	FY2014
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It was classified in Category 3 based on a flash point of 25 deg C (closed cup) (ICSC (1998)). Besides, it is classified in Class 3, PG III (UN1229) in UNRTDG.
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not classified	- -	-	-	There is a chemical group associated with self-reactive properties (unsaturated bond) present in the molecule. However, because it is classified in Class 3, PG III (UN1229) in UNRTDG, it was classified as "Not classified."
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 340 deg C (ICSC (1998)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P362+P364 P264 P270 P330 P501	Based on reports of LD50 values of 600 mg/kg (SIDS (2011)), 655 mg/kg (PATTY (6th, 2012)) and 1,120 mg/kg (PATTY (6th, 2012), SIDS (2011), ACGIH (7th, 2001)) for rats, it was classified in Category 4.
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on reports of LD50 values of 5,181 mg/kg (PATTY (6th, 2012), SIDS (2011)) and 5,150 mg/kg (SIDS (2011)) for rabbits, it was classified as "Not classified."
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	Based on reports of LC50 values (4 hours) of 1,100 ppm (PATTY (6th, 2012), SIDS (2011)) and 2,241 ppm (SIDS (2011)) for rats, it was classified in Category 3. Besides, because the LC50 values were lower than 90% of the saturated vapor concentration (11,846 ppm), the reference value in units of ppm was applied as a vapor without a mist.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	There are reports that marked irritation occurred when 0.5 mL of this substance was applied to mice (PATTY (6th, 2012)), and that mild irritation was produced in a test in which 430 mg of this substance was applied to rabbits (PATTY (6th, 2012)). In addition, there is a description that the liquid phase of this substance is an irritant (HSDB (Access on September 2014)). From the above, based on the result of "marked irritation," it was classified in Category 2.
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	There is a report that severe irritation was caused by application of 0.5 mL of this substance to rabbits (PATTY (6th, 2012)). In addition, there is a report that eye irritation was observed in humans exposed to 25 ppm of this substance (PATTY (6th, 2012), ACGIH (7th, 2001)). From the above, based on "severe irritation" in rats, it was classified in Category 2A.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	As for in vivo, it was negative in a mouse bone marrow micronucleus test (SIDS (2011), PATTY (6th, 2012), HSDB (Access on September 2014)), As for in vitro, it was negative in a bacterial reverse mutation test (SIDS (2011), PATTY (6th, 2012), HSDB (Access on September 2014)). From the above, it was classified as "Classification not possible."
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	Fertility was affected (a reduction in the number of dams which delivered), however, no embryo-fetal toxicity was observed at doses where parental toxicity (a reduction in activity, partially closed eyes, reddish tear, nasal discharge, a reduction in feed consumption and body weight) was observed, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) by the inhalation route with rats (PATTY (6th, 2012), SIDS (2011)). Therefore, it was classified in Category 2.
8	Specific target organ toxicity - Single exposure	Category 3 (respiratory tract irritation, narcotic effects)	Warning	H335 H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	This substance produced respiratory irritation (ACGIH (7th, 2001), PATTY (6th, 2012)). In humans, there are reports of headache, vertigo and difficulty in breathing, and in experimental animals, narcosis, coordination ataxia and loss of reflexes were seen (ACGIH (7th, 2001), PATTY (6th, 2012)). From the above, it was classified in Category 3 (respiratory tract irritation, narcotic effects).
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	In humans, there is no knowledge on repeated exposures. As for experimental animals, there are descriptions that in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422; GLP-compliant)in which rats were repeatedly exposed to the vapor of this substance for 49 days for males and for 36-49 days until day 4 of lactation for females, including 14 days before mating for males and females that exposure-dependent histopathological changes in the respiratory and olfactory epithelium of the nasal passages were observed (SIDS (2011)), and that irritating effects on the respiratory organs as histological change, and nasal exudate, irritant changes in the respiratory and olfactory epithelium, chronic inflammation or focal metaplasia of the epithelium as the inflammatory change were seen (PATTY (6th, 2012)). There is a report that the LOAEL was 31 ppm (124 mg/m3, converted guidance value: 0.068 mg/L/6 hours (Category 1)), where exudate in the olfactory epithelium was the only finding (SIDS (2011)). Decreased body weight gain was observed as systemic effects in this test, but no findings suggesting target organs other than the respiratory organs were seen (SIDS (2011), PATTY (6th, 2012)). There were no other reliable data available for classification. Therefore, from the results of the inhalation exposure test with rats, it was classified in Category 1 (respiratory organs). Besides, the findings in humans in ACGIH (7th, 2001) were described as evidence of the classification in the previous classification, however, it was judged that it could not be used for this classification because it is a description of the effects of acute exposure.
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 3	- -	H402	P273 P501	It was classified in Category 3 from 96-hour LC50 = 71 mg/L for fish (Oncorhynchus mykiss) (SIDS, 2011).
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	Reliable chronic toxicity data were not obtained. It was classified as "Not classified" from a low bioconcentration estimate (LogPow = 1.37 (PHYSPROP Database, 2009)) although it is rapidly degradable (a 14-day degradation rate by BOD = 77.2% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 1977)), and it was classified in Category 3 in acute toxicity.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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