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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	109-60-4
Chemical Name	n-Propyl acetate
Substance ID	H26-B-119, R-056
Classification year (FY)	FY2014
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	- -	-	-	Liquid (GHS definition)
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	It was classified in Category 2 based on a flash point of 14 deg C (closed cup) and a boiling point of 101.6 deg C (ICSC (1996)). Besides, it is classified in Class 3, PG II (UN1276) in UNRTDG.
7	Flammable solids	Not applicable	- -	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 450 deg C (ICSC (1996)).
10	Pyrophoric solids	Not applicable	- -	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.
14	Oxidizing solids	Not applicable	- -	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on reports of LD50 values for rats of >3,200 mg/kg (SIDS (2009)), 8,700 mg/kg (SIDS (2009), ACGIH (7th, 2001)), 9,370 mg/kg (SIDS (2009)), it was classified as "Not classified."
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on a report of an LD50 value of >17,800 mg/kg for rabbits (SIDS (2009), ACGIH (7th, 2001)), it was classified as "Not classified."
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Liquid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Category 4	Warning	H332	P304+P340 P261 P271 P312	Based on reports that by 4-hour exposure at 8,000 ppm with rats, 4/6 animals were dead (PATTY (6th, 2012), SIDS (2009), ACGIH (7th, 2001)) and that an LC50 value (4 hours) was 4,000-8,000 ppm (SIDS (2009)), it was classified in Category 4. Besides, since the LC50 values were lower than 90% of the saturated vapor concentration (47,236 ppm), the reference value in units of ppm was applied as a vapour without a mist. New information sources (PATTY (6th, 2012), SIDS (2009)) were added, and the category was revised.
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. There are 2 reports of non-occlusive application of this substance to rabbits for 24 hours, in which although irritation was not observed in one test, erythema and necrosis were observed in the other study (SIDS (2009)). In addition, there are reports that slight irritation was observed after application to abraded skin in another test with rats (application time unknown) (SIDS (2009)), and that after occlusive application of this substance to the skin of guinea pigs, slight erythema was observed but it was reversible (SIDS (2009)). From the above, since there was no report on 4-hour application and the degrees of irritation of obtained information varied, all of them were considered inadequate to determine the category. Due to the addition of new information in List 1, the category was changed.
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	It is reported that in a test with rabbits, since reversible cornea damage was observed, and the degree of irritation was Grade 2 (1-10), it was slightly irritating (SIDS (2009)). In addition, irritation to the eyes was also reported in cases in humans (HSDB (Access on September 2014)). From the above results, it was classified in Category 2B. Besides, this substance was classified in "Xi; R 36" in the EU DSD classification, and in "Eye Irrit. 2 H319" in the EU CLP classification.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There were no in vivo data. As for in vitro, it was negative in a bacterial reverse mutation test (SIDS (2009)).
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 3 (respiratory tract irritation, narcotic effects)	Warning	H335 H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	This substance was irritating to the respiratory tract (SIDS (2009), ACGIH (7th, 2001), PATTY (6th, 2012), HSDB (Access on September 2014)). In humans, there was a report of weakness, drowsiness and unconsciousness at high concentrations (HSDB (Access on September 2014)). As for experimental animals, there is a description of narcotic effects (OEL Documentations (Japan Society For Occupational Health (JSOH), 1970), ACGIH (7th, 2001), PATTY (6th, 2012)), and there was a report of being inactive and central nervous system depression in an inhalation exposure to rats at 16.7 mg/L (SIDS (2009)). From the above, this substance was considered to have respiratory tract irritation and narcotic effects, therefore, it was classified in Category 3 (respiratory tract irritation, narcotic effects). Besides, in the previous classification, Category 1 (central nervous system) and Category 2 (liver) were adopted, but the effects on the central nervous system were determined as narcotic effects. In addition, there was no report about the liver in List 1 and List 2, and HSFS was not adopted for classification because it was included in List 3.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, although there were descriptions of an inhalation test with rats exposed to the vapour of n-propyl alcohol, a hydrolysate of this substance (SIDS (2009)), and an inhalation test with cats exposed to this substance (IUCLID (2000)), the exposure periods were as short as 5 or 9 days, therefore, the data were not applicable for classification.
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 3	- -	H402	P273 P501	It was classified in Category 3 from 96-hour LC50 = 60 mg/L for fish (Pimephales promelas) (SIDS, 2009).
11	Hazardous to the aquatic environment (Long-term)	Not classified	- -	-	-	If chronic toxicity data are used, then it is classified as "Not classified" due to rapid degradability (a 14-day degradation rate by BOD: 81% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2000)), and 72-hour NOEC = 83.2 mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 2009). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to rapid degradability (a 14-day degradation rate by BOD: 81% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, 2000)), and a low bioaccumulation estimate (log Kow = 1.24 (PHYSPROP Database, 2009)) despite 96-hour LC50 = 60 mg/L for fish (Pimephales promelas) (SIDS, 2009). From the above results, it was classified as "Not classified."
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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