NITE - Chemical Management Field

GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	1305-62-0
Chemical Name	Calcium hydroxide
Substance ID	H26-B-125, -
Classification year (FY)	FY2014
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive properties.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition).
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition).
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition).
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition).
7	Flammable solids	Not classified	- -	-	-	It is not combustible (ICSC (1997)).
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition).
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (ICSC (1997)).
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (ICSC (1997)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Because the observation result of being insoluble in water (ICSC (1997)) was obtained, it is estimated that it does not react vigorously with water.
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition).
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound containing oxygen (but not halogen), but the classification is not possible due to no data.
15	Organic peroxides	Not applicable	- -	-	-	It is an inorganic compound.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on a report of an LD50 value of 7,340 mg/kg for rats (ACGIH (7th, 2001), HSDB (Access on September 2014)), it was classified as "Not classified."
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	There are descriptions that the aqueous solution of this substance is a strong base (pH 12.4), and that it is moderately caustic or irritating to the body surface (ACGIH (7th, 2001)). In addition, there are descriptions that this substance is moderately irritating to the skin of humans (IUCLID (2000)), and that it is corrosive (EPA Pesticide (2005)). From the above information, although this substance is a strong base, based on the descriptions that effects on the skin were "moderate or mild," it was classified in Category 2. It was classified in Category 2.
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	There are descriptions that this substance is a strong base (pH 10.9-11.9 (EPA Pesticide (2005))), and that it is moderately caustic or irritating to the body surface (ACGIH (7th, 2001)). In addition, there is a report that this substance is corrosive to the eyes (IUCLID (2000)), and there is a description that it causes irreversible injury (EPA Pesticide (2005)). From the above results, it was classified in Category 1.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There were no in vivo data. As for in vitro, it was negative in comet assays with cultured mammalian and human cells (HSDB (Access on September 2014)).
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	There are reports that this substance irritates the respiratory tract and is corrosive to the mucosa in humans although data are limited, and that it may cause coughing, chemical burns of mucous membranes, pulmonary edema, vomiting and stomach cramps (ACGIH (7th, 2001), EPA Pesticide (2005), HSDB (Access on September 2014)). There were no data on experimental animals. From the above, there is a description that it is irritating to the respiratory tract of humans and causes pulmonary edema, therefore, it was classified in Category 1 (respiratory organs).
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	There are descriptions that chronic ingestion of this substance can result in inflammatory and ulcerous changes in the mouth and digestive tract by irritation (HSDB (Access on September 2014)), and that atrophic changes in the liver, kidney and stomach and inflammation in the small intestine were observed in a test in which rats were administered by drinking water for 3 months (IUCLID (2000)), however, details including the dose were unknown, therefore, it was not possible to adopt the above for classification. Therefore, classification was not possible due to lack of data. Besides, this substance is certified as GRAS (Generally Recognized As Safe) by FDA in the United States, therefore, the safety is established in the case of normal use in foods as an additive (EPA RED (2005)). Moreover, it was classified in Category 2 (lung) based on an information sources in List 2 in the previous classification. However, in this classification, based on information sources (HSDB, IUCLID) in List 2, effects on "respiratory system" as target organ were confirmed as acute exposure effects (by inhalation in humans, upper respiratory tract discomfort, coughing, chest pain, chemical burns of mucous membranes, and pulmonary edema may occur (HSDB (Access on September 2014))), but it was judged that there is inadequate evidence for classification for repeated exposure effect.
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	-	- -	-	-	-
11	Hazardous to the aquatic environment (Long-term)	-	- -	-	-	-
12	Hazardous to the ozone layer	-	- -	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

To GHS Information