Item | Information |
---|---|
CAS RN | 1305-62-0 |
Chemical Name | Calcium hydroxide |
Substance ID | H26-B-125, - |
Classification year (FY) | FY2014 |
Ministry who conducted the classification | Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE) |
New/Revised | Revised |
Classification result in other fiscal year | FY2006 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | GHS Classification Guidance for the Japanese Government (FY2013 revised edition) |
UN GHS document (External link) | UN GHS document |
Definitions/Abbreviations (Excel file) | Definitions/Abbreviations |
Model Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Model SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | eChemPortal |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Explosives | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive properties. |
2 | Flammable gases (including chemically unstable gases) | Not applicable |
- |
- | - | Solid (GHS definition). |
3 | Aerosols | Not applicable |
- |
- | - | Not aerosol products. |
4 | Oxidizing gases | Not applicable |
- |
- | - | Solid (GHS definition). |
5 | Gases under pressure | Not applicable |
- |
- | - | Solid (GHS definition). |
6 | Flammable liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
7 | Flammable solids | Not classified |
- |
- | - | It is not combustible (ICSC (1997)). |
8 | Self-reactive substances and mixtures | Not applicable |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. |
9 | Pyrophoric liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is not combustible (ICSC (1997)). |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (ICSC (1997)). |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | Because the observation result of being insoluble in water (ICSC (1997)) was obtained, it is estimated that it does not react vigorously with water. |
13 | Oxidizing liquids | Not applicable |
- |
- | - | Solid (GHS definition). |
14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an inorganic compound containing oxygen (but not halogen), but the classification is not possible due to no data. |
15 | Organic peroxides | Not applicable |
- |
- | - | It is an inorganic compound. |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on a report of an LD50 value of 7,340 mg/kg for rats (ACGIH (7th, 2001), HSDB (Access on September 2014)), it was classified as "Not classified." |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
1 | Acute toxicity (Inhalation: Gases) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Vapours) | Not applicable |
- |
- | - | Solid (GHS definition) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 |
P302+P352
P332+P313 P362+P364 P264 P280 P321 |
There are descriptions that the aqueous solution of this substance is a strong base (pH 12.4), and that it is moderately caustic or irritating to the body surface (ACGIH (7th, 2001)). In addition, there are descriptions that this substance is moderately irritating to the skin of humans (IUCLID (2000)), and that it is corrosive (EPA Pesticide (2005)). From the above information, although this substance is a strong base, based on the descriptions that effects on the skin were "moderate or mild," it was classified in Category 2. It was classified in Category 2. |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 |
P305+P351+P338
P280 P310 |
There are descriptions that this substance is a strong base (pH 10.9-11.9 (EPA Pesticide (2005))), and that it is moderately caustic or irritating to the body surface (ACGIH (7th, 2001)). In addition, there is a report that this substance is corrosive to the eyes (IUCLID (2000)), and there is a description that it causes irreversible injury (EPA Pesticide (2005)). From the above results, it was classified in Category 1. |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There were no in vivo data. As for in vitro, it was negative in comet assays with cultured mammalian and human cells (HSDB (Access on September 2014)). |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory organs) |
Danger |
H370 |
P308+P311
P260 P264 P270 P321 P405 P501 |
There are reports that this substance irritates the respiratory tract and is corrosive to the mucosa in humans although data are limited, and that it may cause coughing, chemical burns of mucous membranes, pulmonary edema, vomiting and stomach cramps (ACGIH (7th, 2001), EPA Pesticide (2005), HSDB (Access on September 2014)). There were no data on experimental animals. From the above, there is a description that it is irritating to the respiratory tract of humans and causes pulmonary edema, therefore, it was classified in Category 1 (respiratory organs). |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - |
There are descriptions that chronic ingestion of this substance can result in inflammatory and ulcerous changes in the mouth and digestive tract by irritation (HSDB (Access on September 2014)), and that atrophic changes in the liver, kidney and stomach and inflammation in the small intestine were observed in a test in which rats were administered by drinking water for 3 months (IUCLID (2000)), however, details including the dose were unknown, therefore, it was not possible to adopt the above for classification. Therefore, classification was not possible due to lack of data. Besides, this substance is certified as GRAS (Generally Recognized As Safe) by FDA in the United States, therefore, the safety is established in the case of normal use in foods as an additive (EPA RED (2005)). Moreover, it was classified in Category 2 (lung) based on an information sources in List 2 in the previous classification. However, in this classification, based on information sources (HSDB, IUCLID) in List 2, effects on "respiratory system" as target organ were confirmed as acute exposure effects (by inhalation in humans, upper respiratory tract discomfort, coughing, chest pain, chemical burns of mucous membranes, and pulmonary edema may occur (HSDB (Access on September 2014))), but it was judged that there is inadequate evidence for classification for repeated exposure effect. |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. |
Hazard class | Classification |
Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | |
---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | - |
- |
- | - | - |
11 | Hazardous to the aquatic environment (Long-term) | - |
- |
- | - | - |
12 | Hazardous to the ozone layer | - |
- |
- | - | - |
|