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GHS Classification Result

GENERAL INFORMATION

Item	Information
CAS RN	7758-89-6
Chemical Name	Cuprous chloride
Substance ID	H26-B-129, R-058
Classification year (FY)	FY2014
Ministry who conducted the classification	Ministry of Health, Labour and Welfare (MHLW)/Ministry of the Environment (MOE)
New/Revised	Revised
Classification result in other fiscal year	FY2006
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	GHS Classification Guidance for the Japanese Government (FY2013 revised edition)
UN GHS document (External link)	UN GHS document
Definitions/Abbreviations (Excel file)	Definitions/Abbreviations
Model Label by MHLW (External link)	MHLW Website (in Japanese Only)
Model SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	eChemPortal

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Explosives	Not applicable	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.
2	Flammable gases (including chemically unstable gases)	Not applicable	- -	-	-	Solid (GHS definition).
3	Aerosols	Not applicable	- -	-	-	Not aerosol products.
4	Oxidizing gases	Not applicable	- -	-	-	Solid (GHS definition).
5	Gases under pressure	Not applicable	- -	-	-	Solid (GHS definition).
6	Flammable liquids	Not applicable	- -	-	-	Solid (GHS definition).
7	Flammable solids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on September 2014)).
8	Self-reactive substances and mixtures	Not applicable	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.
9	Pyrophoric liquids	Not applicable	- -	-	-	Solid (GHS definition).
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on September 2014)).
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (GESTIS (Access on September 2014)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Because data of water solubility: 47 mg/L (20 deg C) (SIDS (2006)) were obtained, it is estimated that it does not react vigorously with water.
13	Oxidizing liquids	Not applicable	- -	-	-	Solid (GHS definition).
14	Oxidizing solids	Not classified	- -	-	-	It is an inorganic compound containing halogen (but not oxygen), but the chlorine ion from the chloride does not contribute to oxidization.
15	Organic peroxides	Not applicable	- -	-	-	It is an inorganic compound.
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there is a report of an LD50 value of 140 mg/kg for rats (GESTIS (Access on September 2014)). However, since it is information in List 3, and it was not possible to confirm the original source, it was classified as "Classification not possible." The information source was changed, and the category was revised.
1	Acute toxicity (Dermal)	Not classified	- -	-	-	There are 2 reports of LD50 values of >2,000 mg/kg (male) and >1,224 mg/kg (female) for rats (SIDS (2006)). They corresponded to "Not classified" or "Classification not possible," respectively, therefore, it was classified as "Not classified." A new information source (SIDS (2006)) was added, and the category was revised.
1	Acute toxicity (Inhalation: Gases)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Vapours)	Not applicable	- -	-	-	Solid (GHS definition)
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Since no data for evidence in the previous classification was registered, the category was revised.
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there is a description that hardness and crust on the application site were observed in an acute toxicity test (OECD TG 402) in which this substance was dermally applied for 24 hours (SIDS (2006)), therefore, it may be irritating to the skin.
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, there is a description that copper compounds cause conjunctivitis, ulceration and turbidity of the cornea in the eye (ACGIH (7th, 2001)). However, the data was judged insufficient for use in the classification since specific information such as substance information was unknown.
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	There are neither reports of test results in experimental animals nor epidemiological studies regarding skin sensitization. However, Japan Society For Occupational Health (JSOH) designated copper as occupational skin sensitizers Group 2 (although it indicates the substance itself or its compound, the evaluation does not necessarily apply to all individual chemicals within the group), therefore, it was classified in Category 1.
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a mouse bone marrow micronucleus test (SIDS (2006)). As for in vitro, it was negative in a bacterial reverse mutation test, and it was positive in a chromosomal aberration test with cultured mammalian cells (SIDS (2006), DFGOT vol. 22 (2006)).
6	Carcinogenicity	Classification not possible	- -	-	-	EPA classified this substance as D (IRIS (Access on October 2014)). From the above, it was classified as "Classification not possible."
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There is a report that in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) with rats by the oral route (gavage), at a dose where parental toxicity (death in 3/12 animals, anemia, squamous cell hyperplasia in the forestomach) was observed, no effects on fertility were observed. However, icterus (3/120 animals, 3/9 maternal animals) and runts (2/120 animals, 2/9 maternal animals) were observed in pups (SIDS (2006)). However, maternal toxicity was pronounced, therefore, it was not adopted as evidence for classification.
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Since there were no data on this substance, it was classified as "Classification not possible." Besides, it was reported that by the inhalation exposure to copper dusts and mists in humans, irritation of the respiratory tract, coughing, nausea, headache, gastric pain, vomiting, hemorrhagic gastritis, diarrhea and symptoms similar to metal fume fever were observed. In addition, there is a description of gastrointestinal tract irritation, nausea, vomiting and diarrhea by the oral ingestion of metal copper in humans (ACGIH (7th, 2001), DFGOT vol. 22 (2006)).
9	Specific target organ toxicity - Repeated exposure	Category 2 (haemal system)	Warning	H373	P260 P314 P501	There is no hazardous knowledge by exposure to this substance in humans. In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test in which rats were given this substance orally (gavage), squamous cell hyperplasia of the forestomach was observed at a dose (5 mg/kg/day (converted guidance value: equivalent to about 1.7 mg/kg/day)) corresponding to Category 1 and hematotoxicity effects (decreases in red blood cell count, hemoglobin concentration and hematocrit, increases in white blood cell count, neutrophil ratio and platelet count, bone marrow hyperplasia of the femur) were observed at a dose (80 mg/kg/day (converted guidance value: equivalent to about 26.7 mg/kg/day)) corresponding to Category 2 (SIDS (2006)). Since it was considered that the former is due to the irritating effect on the mucosa from copper and was not included in relevant findings to determine target organs, it was classified in Category 2 (blood system).
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification
11	Hazardous to the aquatic environment (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 96-hour LC50 = 0.018 mg/L for fish (Oncorhynchus mykiss) (ECETOC TR91, 2003).
11	Hazardous to the aquatic environment (Long-term)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 1 due to unknown environmental dynamics of the inorganic compound, and 72-hour NOEC = 0.038 mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 2011). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to unknown environmental dynamics of the inorganic compound, and 96-hour LC50 = 0.018 mg/L for fish (Oncorhynchus mykiss) (ECETOC TR91, 2003). From the above results, it was classified in Category 1.
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.

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